Nicotinamide Riboside Protects the Intestinal Barrier From Heat Stress: Preclinical Findings

Synopsis Heat stress damages the intestinal epithelial barrier, allowing harmful substances to enter the body. This study tested whether nicotinamide riboside (NR), a NAD+ precursor, could protect...

Nicotinamide Riboside Restores Mitochondrial Activity and Thermogenesis in Brown Fat: Preclinical Findings

Synopsis Brown adipose tissue (BAT) depends on NAD+ biosynthesis for healthy mitochondrial function and thermogenesis. Multi-omics analysis of BXD mouse strains showed that BAT NAD+ metabolism str...

Safety of Intravenous Nicotinamide Riboside Across Multiple Doses in Rats: Preclinical Findings

Synopsis This study evaluated the safety of repeated intravenous nicotinamide riboside (NR) at varying doses in Wistar rats. NR was well-tolerated at 150, 300, and 450 mg/kg, with no adverse effec...

Nicotinamide Riboside Protects Against Doxorubicin Cardiotoxicity: Preclinical Findings

Synopsis In human iPSC-derived cardiomyocytes, nicotinamide riboside (NR) improved mitochondrial fusion, enhanced oxidative phosphorylation and ATP production, and upregulated ERRα, a key metaboli...

NAD+ Augmentation as a Disease-Modifying Strategy for Neurodegeneration: Review

SynopsisNeurodegenerative diseases are a growing global health problem with no current treatments that slow or stop their progression. Boosting nicotinamide adenine dinucleotide (NAD+) has emerged ...

Nicotinamide Riboside Prevents Oocyte Quality Loss in Maternal Diabetes: Preclinical Findings

Synopsis Diabetes reduces NAD+ levels in ovaries and oocytes, leading to poor oocyte quality, abnormal spindle formation, excess ROS, and impaired embryo development. In streptozotocin-induced dia...

Mixed-Mode LC-MS Method Quantifies NAD+ and Its Metabolites: Preclinical Findings

Synopsis Measuring NAD+ and its metabolites is technically difficult because these molecules are highly polar and poorly retained by standard chromatography. This study developed a robust mixed-mo...

Combined Metabolic Activators Improve Brain and Liver Function in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial dysfunction and metabolic problems are major contributors to neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). Research shows that combined metabolic...

Nicotinamide Riboside Alleviates Bone Cancer Pain by Restoring Mitochondrial Function: Preclinical Findings

Synopsis Bone cancer pain (BCP) disrupts mitochondrial function in spinal cord neurons, leading to damaged mitochondrial structure, reduced ATP production, and decreased membrane potential (MMP). ...

Nicotinamide Riboside Restores Lipid Handling in Diabetic Heart Disease: Preclinical Findings

Synopsis Excessive lipid droplet buildup and lipotoxicity contribute to diabetic cardiomyopathy (DCM). This study found that lipophagy—the autophagic breakdown of lipid droplets—is impaired in DCM...

NAD+ Restores Heart Function in Heart Failure via Ketone Production: Preclinical Findings

Synopsis Heart failure with preserved ejection fraction (HFpEF) is a common form of heart failure with few treatment options. This study found that the heart can make ketones using the enzyme HMGC...

Nicotinamide Riboside Reduces Inflammation in Retinal Degeneration: Preclinical Findings

Synopsis Bright light exposure triggers mitochondrial damage in the retina, releasing double-stranded DNA that activates the cGAS-STING inflammatory pathway and drives microglial pyroptosis, accel...

The Effects of Boosting NAD+ on Atherosclerosis and Inflammation: Preclinical Findings

SynopsisNAD+ is a key molecule that activates sirtuins, which are linked to benefits like lifespan extension and improved metabolism in mice. Supplements like nicotinamide riboside (NR) are used to...

Nicotinamide Riboside Improves Mitochondrial Health in Werner Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) is a rare accelerated aging disease caused by mutations in the WRN gene, leading to metabolic problems and premature cell aging. This study found that loss of WRN incre...

Nicotinamide Riboside Restores Mitochondrial Function in Alzheimer's Disease: Preclinical Findings

Synopsis Mutant APP and amyloid-β (Aβ) disrupt mitochondrial dynamics and damage synapses in Alzheimer’s disease (AD), partly due to impaired mitophagy, the removal of dysfunctional mitochondria. ...

Nicotinamide Riboside and NMN Boost NAD+ Through Microbiota Conversion: Preclinical Findings

Synopsis Using NAD+ metabolomics in mice, this study found that nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are not directly absorbed intact in large amounts. Instead, most or...

Nicotinamide Riboside and Necroptosis Inhibition Improve ALS: Preclinical Findings

Synopsis TBK1 loss-of-function mutations linked to amyotrophic lateral sclerosis (ALS) were modeled in zebrafish using CRISPR and morpholino knockdown. Both approaches caused early motor deficits,...

Nicotinamide Riboside Protects Against Chronic Kidney Disease by Boosting Metabolism: Preclinical Findings

SynopsisChronic kidney disease (CKD) impairs kidney metabolism, including fatty acid breakdown, and is linked to low NAD+ levels. This study tested nicotinamide riboside (NR), a precursor of NAD+, ...

Nicotinamide Riboside Protects Kidneys after Heart Attack: Preclinical Findings

SynopsisCardiorenal syndrome type 1 occurs when acute kidney injury (AKI) develops after sudden heart problems like a heart attack (MI), increasing the risk of death. This study tested whether nico...

NMN and NR Improve Lipid Metabolism but Promote Atherosclerosis in ApoE-Knockout Mice: Preclinical Findings

Synopsis Supplementation with nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) raised NAD+ levels and produced clear metabolic benefits in mice, including reduced body weight, lowe...