Comparative NAD-Boosting Efficacy of BluNADBooster (LN22199), Nicotinamide Riboside, and Their Combination in Healthy Aging Adults: Clinical Findings

Objectives To determine the effects of BluNADBooster (LN22199), NR, or their combination on blood NAD+ levels, CD38 activity, inflammatory markers, cognitive function, physical performance, and qu...

Nicotinamide Riboside Slows Cognitive Decline in Aging Mice: Preclinical Findings

Synopsis Cognitive decline affects a significant number of older adults, and as people age, changes in brain immune cells (microglia) and decreasing NAD+ levels may contribute to this decline. In ...

Reishi Mushroom Delays Kidney Aging Through Gut Microbiota and Nicotinamide Riboside: Preclinical Findings

Synopsis Ganoderma lucidum (G. lucidum), also known as Reishi mushroom, has been valued in traditional Chinese medicine (TCM) for its anti-aging and kidney-protective properties. This study explor...

Nicotinamide Riboside Increases Stress Sensitivity and Alters Blood Cell Composition in Aging: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a precursor to NAD⁺, a key molecule for cellular energy that declines with age. Aging can cause reduced brain and immune function, changes in blood, and greate...

Role of NAD+ in Aging and Disease: Review

SynopsisNAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive declin...

Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS). Journal Aging Cell Key Outcomes NR improved arterial stiffness, as measured by the...

Nicotinamide Riboside and NMN Enhance CAR-T Cell Function in Aging: Preclinical Findings

Synopsis Chimeric antigen receptor (CAR) T cell therapy is a powerful cancer treatment, but its effectiveness declines with aging. This study found that CAR-T cells from aged female mice show mito...

Nicotinamide Riboside Improves Mitochondrial Health in Werner Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) is a rare accelerated aging disease caused by mutations in the WRN gene, leading to metabolic problems and premature cell aging. This study found that loss of WRN incre...

Nicotinamide Riboside Reduces Airway Inflammation in COPD: Clinical Findings

Objectives To investigate the effects of NR supplementation on airway inflammation and cellular senescence in previously smoking patients with chronic obstructive pulmonary disease (COPD). Journal...

Nicotinamide Riboside Inhibits CD38 in Living Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy production, metabolism, and cell signaling, but its levels naturally decline with age and disease. One key reason for this...

Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Senescence: Preclinical Findings

Synopsis Radiation therapy for cancer often damages the intestines, leading to long-term side effects known as delayed effects of acute radiation exposure (DEARE). This study investigated whether ...

Nicotinamide Riboside Protects Mitochondria in Aging Kidneys: Preclinical Findings

SynopsisAs kidneys age, their cells, especially in the distal tubules, undergo changes in mitochondrial structure and function, but little is known about how aging or anti-aging interventions affec...

Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD). Journal Natur...

Nicotinamide Riboside Restores NAD+ Levels and Improves Metabolism in Diastolic Heart Failure: Preclinical Findings

Synopsis Heart failure with left ventricular diastolic dysfunction is a growing health problem worldwide. This study looked at levels of NAD+, a key metabolic cofactor, in the hearts of patients w...

Nicotinamide Riboside Slows Intervertebral Disc Degeneration: Preclinical Findings

Synopsis Intervertebral disc degeneration (IVDD) is a common age-related condition that causes chronic back pain and reduced mobility. This study investigated how nicotinamide riboside (NR)—a vita...

Nicotinamide Riboside Ameliorates Senescence-Associated Alterations in Gastric Parietal Cells: Preclinical Findings

Synopsis Aging causes widespread cellular decline, including in the gastrointestinal (GI) tract, where reduced digestive function and nutrient absorption often occur. This study examined how aging...

Impact of NAD+ Metabolism on Ovarian Aging: Review

SynopsisNAD+ is a key coenzyme for energy production and many other vital cell functions, including metabolism, DNA repair, gene regulation, aging, and immune health. Low NAD+ levels are directly l...

Roles of NAD+ in Health and Aging: Review

SynopsisNAD+ supports essential processes including metabolism, energy production, DNA repair, mitophagy, inflammation control, and brain function, but its levels drop with aging, affecting all rec...

Nicotinamide Riboside and Phycocyanin Oligopeptides Reduce Stress-Induced Cellular Aging: Preclinical Findings

Synopsis Chronic stress accelerates cellular aging and increases inflammation and oxidative damage, but certain nutrients may help protect against these effects. In this study, researchers tested ...

Nicotinamide Riboside Protects Against Ionizing Radiation-Induced Aging: Preclinical Findings

Synopsis Radiation therapy effectively kills cancer cells but can also damage healthy tissues, leading to premature aging and long-term side effects in survivors. In this study, researchers used a...