NAD+ Reverses Alzheimer’s Deficits: Preclinical Findings

Synopsis Alternative splicing defects are common features of aging and Alzheimer's disease (AD). This study identifies a previously unknown way that boosting NAD+ restores brain function: NAD+ hel...

Stem Cell Membrane–Coated Nanodrugs with Nicotinamide Riboside Targets Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a complex neurodegenerative disorder that urgently requires more effective, precisely targeted treatments. This study developed a biomimetic nanomedicine desig...

Combined Metabolic Activators Improve Brain and Liver Function in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial dysfunction and metabolic problems are major contributors to neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). Research shows that combined metabolic...

Nicotinamide Riboside Restores Mitochondrial Function in Alzheimer's Disease: Preclinical Findings

Synopsis Mutant APP and amyloid-β (Aβ) disrupt mitochondrial dynamics and damage synapses in Alzheimer’s disease (AD), partly due to impaired mitophagy, the removal of dysfunctional mitochondria. ...

Nicotinamide Riboside Supplementation Improves Alzheimer's Biomarkers in Subjective Cognitive Decline and Mild Cognitive Impairment: Clinical Findings

Objectives To test the safety and efficacy of oral NR supplementation on cognition and Alzheimer's disease (AD) blood biomarkers in older adults with subjective cognitive decline and mild cognitiv...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...

Nicotinamide Riboside Supports Brain Health and Reduces Inflammation in Alzheimer’s Disease: Preclinical Findings

SynopsisNicotinamide riboside (NR), a precursor of NAD+, can improve cognitive function and reduce brain inflammation in Alzheimer's disease (AD) mouse models, even without affecting beta-amyloid p...

Nicotinamide Riboside Reduces Oxidative Stress in Alzheimer's Disease: Preclinical Findings

Synopsis Mitophagy—the process by which damaged mitochondria are removed—is essential for maintaining brain cell health and preventing neurodegeneration. In this study, researchers examined fibrob...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...

Combined Metabolic Activators Including Nicotinamide Riboside Improve Metabolism in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are linked to metabolic problems, including mitochondrial dysfunction. This study analyzed human brai...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

SynopsisAlzheimer's disease (AD) is associated with gut microbiota imbalances. In APP/PS1 transgenic AD mice, gut microbiome diversity was reduced and composition altered compared to wild-type mice...

Nicotinamide Riboside and Caffeine Partially Increase Energy in Alzheimer’s Disease: Preclinical Findings

Synopsis As people age, levels of NAD+, a key molecule for energy production, decline, and low NAD+ is linked to energy problems in late-onset Alzheimer’s disease (LOAD). This study tested whether...

EPB41L4A-AS1 and Nicotinamide Riboside Support Brain Energy and Slow Aging: Preclinical FIndings

Synopsis The long non-coding RNA EPB41L4A-AS1 helps regulate NAD+ and ATP production in the brain, which are critical for energy and cellular function. In aging and Alzheimer's disease, EPB41L4A-A...

Mitophagy Enhancers, Including Nicotinamide Riboside, Protect Neurons from Tau-Induced Damage in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease (AD), abnormal tau proteins damage mitochondria and synapses, leading to impaired energy production and neuron loss. In mouse hippocampal neurons expressing mutant ...

Mitophagy Enhancers, Including Nicotinamide Riboside, Are Protective in Alzheimer's Disease: Preclinical Findings

Synopsis This study examines whether mitophagy enhancers can protect brain cells from the harmful effects of mutant APP and amyloid beta (Aβ) in Alzheimer’s disease (AD). Since mitochondrial dysfu...

Nicotinamide Riboside Reduces Brain Inflammation and Cellular Aging in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease, brain cells often show low NAD+ levels, high inflammation, and impaired cellular cleanup of damaged components. In mice with Alzheimer’s-like brain changes, five m...

Nicotinamide Riboside Improves Memory and Brain Health in Alzheimer's Disease and Aging: Preclinical Findings

Synopsis Increasing NAD+ levels to repair damaged mitochondria is a promising strategy for treating Alzheimer’s disease (AD) and other forms of dementia. Nicotinamide riboside (NR) is a safe NAD+ ...

The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...

Nicotinamide Riboside Reduces Amyloid Plaque Formation and Improves Contextual Memory in Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a devastating neurodegenerative disorder driven by the accumulation of toxic amyloid-β (Aβ) protein aggregates. This study identifies a conserved mitochondrial...