Nicotinamide Riboside Supports Brain Health and Reduces Inflammation in Alzheimer’s Disease: Preclinical Findings

SynopsisNicotinamide riboside (NR), a precursor of NAD+, can improve cognitive function and reduce brain inflammation in Alzheimer's disease (AD) mouse models, even without affecting beta-amyloid p...

Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

SynopsisAlzheimer's disease (AD) is associated with gut microbiota imbalances. In APP/PS1 transgenic AD mice, gut microbiome diversity was reduced and composition altered compared to wild-type mice...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...

Nicotinamide Riboside Reduces Brain Inflammation and Cellular Aging in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease, brain cells often show low NAD+ levels, high inflammation, and impaired cellular cleanup of damaged components. In mice with Alzheimer’s-like brain changes, five m...

The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...

Nicotinamide Riboside Supplementation Improves Alzheimer's Biomarkers in Subjective Cognitive Decline and Mild Cognitive Impairment: Clinical Findings

Objectives To test the safety and efficacy of oral NR supplementation on cognition and Alzheimer's disease (AD) blood biomarkers in older adults with subjective cognitive decline and mild cognitiv...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...