Benefits of At-Home Nicotinamide Riboside Injections: Clinical Findings

Objectives To assess NR injection safety and explore effects on NAD+, cellular energy metabolism, oxidative stress, fatigue, and sleep. Journal medRxiv Key Outcomes Both the 50 mg and 100 mg subc...

Benefits of In-Clinic Nicotinamide Riboside Injections: Clinical Findings

Objectives To assess NR injection safety, whole-blood NAD+ responses, and exploratory changes in fatigue, sleep, and perceived physical health. Journal medRxiv Key Outcomes By Day 10, participant...

Effects of Nicotinamide Riboside in Early Stage Parkinson's Disease: Clinical Findings

Objectives To determine whether NR supplementation improves physical outcomes in early PD. Journal JAMA Key Outcomes NR did not improve clinical outcomes. Overall disease severity worsened modest...

Nicotinamide Riboside Improves Mobility in Mitochondrial DNA Disease: Clinical Findings

Objectives To evaluate safety, physical function, and mitochondrial responses to NR supplementation. Journal Genome Medicine Key Outcomes NR supplementation significantly, but minimally, improved...

Effects of Nicotinamide Riboside in Mild Cognitive Impairment: Clinical Findings

Objectives To assess the safety and preliminary effects of NR supplementation on cognition, brain blood flow, and vascular function. Journal Alzheimer's & Dementia Key Outcomes NR increased b...

Nicotinamide Riboside Slows Biological Aging by 2.5 Years: Clinical Findings

Objectives To investigate the effects of NR supplementation and high-intensity interval training on skeletal muscle epigenetic aging, as assessed by DNA methylation–based epigenetic clocks and mea...

Nicotinamide Riboside Linked to Reduced Inflammatory Gene Activity in Ataxia Telangiectasia: Clinical Findings

Objectives To define molecular signatures of ataxia telangiectasia (AT) and to assess changes in inflammatory gene activity in blood immune cells in response to NR supplementation. Journal Interna...

NR and Ketone Salts Help Preserve Brain Myelin in Mild Cognitive Impairment: Clinical Findings

Objectives To determine whether combining ketone salts with NR could improve brain ketone and glucose metabolism in adults with MCI, and assess effects on white-matter structure, cognitive perform...

Safety of Nicotinamide Riboside Injections: Clinical Findings

Objectives To assess intravenous, sub-Q, or IM NR injection tolerability and monitor adverse events, vital signs, and laboratory safety measures. Journal medRxiv Key Outcomes Across both studies,...

Nicotinamide Riboside Reduces Inflammation in Psoriasis: Clinical Findings

Objectives To investigate the anti-inflammatory effects of NR supplementation in psoriasis and its underlying mechanisms. Journal JCI Insight Key Outcomes NR increased whole blood NAD+ levels by ...

Nicotinamide Riboside In Combination with Exercise Improves Cardiopulmonary Fitness in Friedreich's Ataxia: Clinical Findings

Objectives To evaluate the effects of aerobic and resistance exercise training, alone and in combination with NR supplementation, on cardiopulmonary (heart-lung) fitness and blood sugar control in...

Topical Nicotinamide Riboside Improves Skin Hydration and Redness: Clinical Findings

Objectives To assess the irritation potential and short-term effects of topical NR administration on hydration, redness, glossiness, and skin-barrier measures. Journal Preprints Key Outcomes NR a...

Nicotinamide Riboside Blend Improves Hair Density in Humans: Clinical Findings

Objectives To determine whether MiAc could increase mitochondrial activity and signals involved in hair growth in human cells, and whether shampoo or scalp-tonic formulations containing MiAc could...

Nicotinamide Riboside Increases NAD+ More Than NMN: Clinical Findings

Objectives To investigate the blood and brain pharmacokinetics of NR and NMN in healthy individuals and PD patients. Journal iScience Key Outcomes During the pilot portion, NR supplementation did...

Differential Effects of NR, NMN, and Nicotinamide on NAD+ and Microbial Metabolism: Clinical Findings

Objectives To compare the effects of NR, NMN, and NAM on NAD+ levels and investigate how gut microbes metabolize each precursor. Journal Nature Metabolism Key Outcomes NR and NMN produced similar...

Real-World Tolerability of Intravenous Infusion of NAD+ vs. NR: Clinical Findings

Objectives To compare commercially administered NAD+ IV and NR IV in humans by evaluating infusion time, tolerability, safety markers, and metabolic outcomes. Journal Frontiers in Aging Key Outcom...

Effects of Nicotinamide Riboside Supplementation on Nerve Fiber Protection and Axon Regeneration: Clinical Findings

Objectives To investigate whether boosting NAD+ levels through nicotinamide riboside (NR) supplementation can protect against or promote regeneration of small somatic sensory axons in human skin f...

Thiamine and Nicotinamide Riboside Improve Symptoms in Charcot-Marie-Tooth Neuropathy: Case Report

Objectives To identify the mechanistic basis of GDAP1 dysfunction in CMT2K and test whether targeted metabolic activation using thiamine and NR can therapeutically correct mitochondrial biochemica...

Nicotinamide Riboside Prevents and Enhances Therapy in Pancreatic Ductal Adenocarcinoma: Preclinical Findings

Synopsis Pancreatic ductal adenocarcinoma (PDAC) shows progressive loss of SIRT3, a mitochondrial deacetylase whose downregulation correlates with poor patient survival. Using spontaneous and expe...

Nicotinamide Riboside Improves Stroke Recovery by Modulating Monocyte Metabolism: Preclinical Findings

Synopsis Aging worsens post-stroke outcomes by amplifying neuroinflammation. This study examined whether older circulating monocytes exhibit altered metabolism after stroke and whether boosting NA...