Effects of Nicotinamide Riboside Supplementation on Nerve Fiber Protection and Axon Regeneration: Clinical Findings

Objectives To investigate whether boosting NAD+ levels through nicotinamide riboside (NR) supplementation can protect against or promote regeneration of small somatic sensory axons in human skin f...

Nicotinamide Riboside Improves Stroke Recovery by Modulating Monocyte Metabolism: Preclinical Findings

Synopsis Aging worsens post-stroke outcomes by amplifying neuroinflammation. This study examined whether older circulating monocytes exhibit altered metabolism after stroke and whether boosting NA...

Comparative NAD-Boosting Efficacy of BluNADBooster (LN22199), Nicotinamide Riboside, and Their Combination in Healthy Aging Adults: Clinical Findings

Objectives To determine the effects of BluNADBooster (LN22199), NR, or their combination on blood NAD+ levels, CD38 activity, inflammatory markers, cognitive function, physical performance, and qu...

Nicotinamide Riboside Slows Cognitive Decline in Aging Mice: Preclinical Findings

Synopsis Cognitive decline affects a significant number of older adults, and as people age, changes in brain immune cells (microglia) and decreasing NAD+ levels may contribute to this decline. In ...

Nicotinamide Riboside Increases NAD+ Levels and Improves Symptom Recovery in Long COVID: Clinical Findings

Objectives To investigate the effects of NR supplementation on NAD+ levels, cognitive function, and long COVID symptoms in non-hospitalized individuals with long COVID.  Journal The Lancet eClinic...

NAD+ Reverses Alzheimer’s Deficits: Preclinical Findings

Synopsis Alternative splicing defects are common features of aging and Alzheimer's disease (AD). This study identifies a previously unknown way that boosting NAD+ restores brain function: NAD+ hel...

Nicotinamide Riboside Counteracts Alcohol-Induced Neurotoxicity: Preclinical Findings

Synopsis Excessive alcohol intake causes cognitive impairment and neuronal injury driven by oxidative stress, inflammation, and profound mitochondrial dysfunction. This study shows that NRC, an NA...

Nicotinamide Riboside Protects Against High-Altitude Hypoxia Brain Injury: Preclinical Findings

Synopsis Exposure to low oxygen at high altitudes can harm learning and memory by affecting neuron function and connections in the hippocampal CA1 region of the brain. Research shows that mitochon...

S-Adenosylmethionine and Nicotinamide Riboside Supplementation Improves Fatigue and Stabilizes Vision in PRPS1 Deficiency: Case Report

Objectives To evaluate the impact of S-Adenosylmethionine (SAMe) and NR supplementation on the clinical symptoms of PRPS1 deficiency, specifically focusing on fatigue, cognitive decline, and visio...

Stem Cell Membrane–Coated Nanodrugs with Nicotinamide Riboside Targets Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a complex neurodegenerative disorder that urgently requires more effective, precisely targeted treatments. This study developed a biomimetic nanomedicine desig...

Nicotinamide Riboside Restores Vascular Health in ACTA2 Mutation: Preclinical Findings

Synopsis Mutations in ACTA2 affecting arginine 179 cause early-onset strokes due to moyamoya-like artery blockages. This study found that mutant smooth muscle cells (SMCs) remain immature, highly ...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...

NAD+ Augmentation as a Disease-Modifying Strategy for Neurodegeneration: Review

SynopsisNeurodegenerative diseases are a growing global health problem with no current treatments that slow or stop their progression. Boosting nicotinamide adenine dinucleotide (NAD+) has emerged ...

Combined Metabolic Activators Improve Brain and Liver Function in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial dysfunction and metabolic problems are major contributors to neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). Research shows that combined metabolic...

Nicotinamide Riboside Restores Mitochondrial Function in Alzheimer's Disease: Preclinical Findings

Synopsis Mutant APP and amyloid-β (Aβ) disrupt mitochondrial dynamics and damage synapses in Alzheimer’s disease (AD), partly due to impaired mitophagy, the removal of dysfunctional mitochondria. ...

Nicotinamide Riboside and Necroptosis Inhibition Improve ALS: Preclinical Findings

Synopsis TBK1 loss-of-function mutations linked to amyotrophic lateral sclerosis (ALS) were modeled in zebrafish using CRISPR and morpholino knockdown. Both approaches caused early motor deficits,...

Nicotinamide Riboside Reduces Sweetener-Induced Neurocognitive Impairments: Preclinical Findings

Synopsis Around the world, many people consume sweeteners, with sweet beverages being a major source. Previous studies have shown that too many sweeteners can harm health, including affecting brai...

Nicotinamide Riboside Supplementation Improves Alzheimer's Biomarkers in Subjective Cognitive Decline and Mild Cognitive Impairment: Clinical Findings

Objectives To test the safety and efficacy of oral NR supplementation on cognition and Alzheimer's disease (AD) blood biomarkers in older adults with subjective cognitive decline and mild cognitiv...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...

Nicotinamide Riboside Supplementation with Metabolic Activators Improves Cognitive Function in Parkinson’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of NR, L-carnitine tartrate, serine, and N-acetyl-L-cysteine (NAC), could be used to treat Parki...