Article: Nicotinamide Riboside Improves Blood Cell Formation in Aging and Ataxia Telangiectasia: Preclinical Findings

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Ataxia Telangiectasia Healthy Aging & Longevity Immune Health Preclinical

Nicotinamide Riboside Improves Blood Cell Formation in Aging and Ataxia Telangiectasia: Preclinical Findings

Synopsis

NAD+ supplements can boost mitochondrial health and DNA repair, which benefits stem cells in aging or disease. This study tested nicotinamide riboside (NR) in mice with reduced blood stem cell function due to aging or genetic defects. NR treatment improved the stem cells' ability to produce lymphoid cells (important immune cells) during treatment. In aged mice, this effect lasted in competitive transplant tests and involved changes in gene expression favoring lymphoid over myeloid cells. However, once NR was stopped, these gene changes faded. These findings show that NR temporarily shifts stem cell function toward better immune potential in compromised animals.

Journal

npj Aging and Mechanisms of Disease

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Diabetes

Nicotinamide Riboside Improves Insulin Resistance by Boosting Mitochondrial Function in Skeletal Muscle: Preclinical Findings

SynopsisHigh-fat diet-induced insulin resistance (IR) in skeletal muscle is linked to mitochondrial dysfunction and oxidative stress. This study assessed whether nicotinamide riboside (NR) could re...

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Mitochondrial Health

Nicotinamide Riboside Helps Maintain Mitochondrial Health and Meat Quality in Pork: Preclinical Findings

SynopsisEarly postmortem muscle mitochondrial function and cell death affect pork quality, including color stability. This study tested whether nicotinamide riboside (NR) given to pigs before harve...

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