Nicotinamide Riboside Helps Improve Symptoms in Lupus: Preclinical Findings

SynopsisThe protein PPP2R2A helps regulate the immune system, and in lupus-prone mice, T cells lacking this protein caused less autoimmunity and kidney damage. Without PPP2R2A, T cells produced mor...

Nicotinamide Riboside Supplementation Reduces Inflammatory Markers in Immune Cells from Healthy Subjects and Psoriasis Patients: Clinical Findings

Objectives To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in viv...

Nicotinamide Riboside Ameliorates Inflammation and Joint Damage in Rheumatoid Arthritis: Preclinical Findings

Synopsis This study investigated how NAD+ metabolism affects rheumatoid arthritis (RA) and whether NAD+ boosters could improve disease outcomes. Researchers analyzed blood samples from 253 partici...

Nicotinamide Riboside Supplementation Boosts NAD+ and Lowers Inflammatory Immune Signaling in Lupus: Clinical Findings

Objectives To explore the anti-inflammatory effects of NR in monocytes (a type of white blood cell; immune cell) extracted from young, healthy subjects following supplementation. Additionally, the...

Counteracting CD38-Induced NAD+ Depletion Reduces Multiple Organ Fibrosis: Preclinical Findings

SynopsisSystemic sclerosis (SSc) involves fibrosis in multiple organs, but its cause is not fully understood. NAD+ decline with age and disease, often due to increased CD38 activity (an NADase), ma...