Nicotinamide Riboside Prevents and Enhances Therapy in Pancreatic Ductal Adenocarcinoma: Preclinical Findings

Synopsis Pancreatic ductal adenocarcinoma (PDAC) shows progressive loss of SIRT3, a mitochondrial deacetylase whose downregulation correlates with poor patient survival. Using spontaneous and expe...

Nicotinamide Riboside Improves Stroke Recovery by Modulating Monocyte Metabolism: Preclinical Findings

Synopsis Aging worsens post-stroke outcomes by amplifying neuroinflammation. This study examined whether older circulating monocytes exhibit altered metabolism after stroke and whether boosting NA...

Nicotinamide Riboside Slows Cognitive Decline in Aging Mice: Preclinical Findings

Synopsis Cognitive decline affects a significant number of older adults, and as people age, changes in brain immune cells (microglia) and decreasing NAD+ levels may contribute to this decline. In ...

Nicotinamide Riboside Protects Against NASH: Preclinical Findings

Synopsis In a rat model of NASH driven by type 2 diabetes and an obesogenic diet, activating SIRT2 with nicotinamide riboside (NR) improved blood sugar, insulin resistance, and glucose tolerance, ...

Mechanistic Insights into NAD+ Driven Activation of Phosphite Dehydrogenase: Preclinical Findings

Synopsis Research shows that the energy from the ADP part of the NAD+ molecule helps drive a shape change in phosphite dehydrogenase (PTDH), which activates the enzyme to transfer a hydride from p...

NAD+ Reverses Alzheimer’s Deficits: Preclinical Findings

Synopsis Alternative splicing defects are common features of aging and Alzheimer's disease (AD). This study identifies a previously unknown way that boosting NAD+ restores brain function: NAD+ hel...

NAD+ Depletion Drives Cartilage Damage in Osteoarthritis: Preclinical Findings

Synopsis Earlier research showed that people with osteoarthritis (OA) have lower levels of NAD+, an important energy-related molecule, in their cartilage. This study found that NAD+ levels are red...

Nicotinamide Riboside and B Vitamins Restore Heart Energy in Heart Failure: Preclinical Findings

Synopsis Heart failure (HF) affects the heart’s energy supply, but current treatments do not directly fix this problem. In a study using mice with established HF, a diet supplemented with three B ...

Nicotinamide Riboside Counteracts Alcohol-Induced Neurotoxicity: Preclinical Findings

Synopsis Excessive alcohol intake causes cognitive impairment and neuronal injury driven by oxidative stress, inflammation, and profound mitochondrial dysfunction. This study shows that NRC, an NA...

Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Injury: Preclinical Findings

Synopsis Radiation-induced intestinal injury (IR) is a major complication of colorectal cancer radiotherapy. This study shows that nicotinamide riboside (NR) markedly reduces IR severity in mice, ...

Nicotinamide Riboside Plus Magnesium-L-Theanine Protects Against Stress-Induced Gut–Liver Injury: Preclinical Findings

Synopsis Chronic stress can harm the gut and liver by disrupting metabolism and causing oxidative damage. This study tested the protective effects of nicotinamide riboside (NR) and magnesium-L-the...

Nicotinamide Riboside Restores Bone Health in Glucocorticoid-Induced Osteoporosis: Preclinical Findings

Synopsis Glucocorticoid-induced osteoporosis (GIOP) is a major side effect of long-term steroid use, caused by damage to osteoblasts—the bone-forming cells. Recent studies show that ferroptosis, a...

Nicotinamide Riboside Protects Against High-Altitude Hypoxia Brain Injury: Preclinical Findings

Synopsis Exposure to low oxygen at high altitudes can harm learning and memory by affecting neuron function and connections in the hippocampal CA1 region of the brain. Research shows that mitochon...

Nicotinamide Mononucleotide and Nicotinamide Riboside Protect Against Skin Aging: Preclinical Findings

Synopsis In human skin fibroblasts subjected to oxidative and photo-aging stress, nicotinamide mononucleotide (NMN) markedly increased NAD+ levels, activated sirtuin and autophagy pathways, and im...

Nicotinamide Riboside Prevents Diabetic Cardiomyopathy: Preclinical Findings

Synopsis In a mouse model of diabetic cardiomyopathy (DCM) induced by STZ and a high-fat diet, nicotinamide riboside (NR) (400 mg/kg/day) lowered fasting glucose and insulin levels, improved diast...

NR Restores NAD+ and Protects Heart Cells from Fatty Acid Damage: Preclinical Findings

Synopsis This study looks at how fatty acids (FAs) affect heart cells (cardiomyocytes) by reducing their ability to take in glucose, especially after a lack of oxygen (ischemia–reperfusion injury)...

Nicotinamide Riboside Reduces Liver Inflammation in Alcoholic Liver Disease: Preclinical Findings

Synopsis Alcoholic liver disease (ALD) is a serious liver condition caused by excessive alcohol and has few effective nutritional treatments. Researchers found that brown fat cells release a prote...

Impact of Energy Production Proteins and Molecules in Triple-Negative Breast Cancer: Preclinical Findings

Synopsis Triple-negative breast cancer (TNBC) is a very aggressive cancer with few treatment options and a high ability to spread. This study found that TNBC cells use a process in their mitochond...

Nicotinamide Riboside Protects Against Doxorubicin-Induced Liver and Kidney Toxicity: Preclinical Findings

Synopsis Doxorubicin (DOX) is a powerful chemotherapy drug, but its use is limited because it causes serious liver and kidney toxicity through ferroptosis, an iron-dependent form of cell death dri...

Nicotinamide Riboside and Pyruvate Increase Anti-Inflammatory Pathways: Preclinical Findings

Synopsis This study uncovered a previously unknown anti-inflammatory metabolite, homocysitaconate, produced through the interaction of homocysteine and itaconate during inflammation. The enzyme S-...