Nicotinamide Riboside Prevents Diabetic Cardiomyopathy: Preclinical Findings

Synopsis In a mouse model of diabetic cardiomyopathy (DCM) induced by STZ and a high-fat diet, nicotinamide riboside (NR) (400 mg/kg/day) lowered fasting glucose and insulin levels, improved diast...

NR Restores NAD+ and Protects Heart Cells from Fatty Acid Damage: Preclinical Findings

Synopsis This study looks at how fatty acids (FAs) affect heart cells (cardiomyocytes) by reducing their ability to take in glucose, especially after a lack of oxygen (ischemia–reperfusion injury)...

Nicotinamide Riboside-Containing β-Hydroxybutyrate Supplementation (NHS101) in Children with Multiple Acyl-CoA Dehydrogenase or Pyruvate Dehydrogenase Deficiency: Case Report

Objective To evaluate the efficacy of a new preparation of dextro-β hydroxybutyrate salt mixture containing NR (NHS101) in patients with metabolic disorders affecting energy metabolism, specificall...

Nicotinamide Riboside Reduces Liver Inflammation in Alcoholic Liver Disease: Preclinical Findings

Synopsis Alcoholic liver disease (ALD) is a serious liver condition caused by excessive alcohol and has few effective nutritional treatments. Researchers found that brown fat cells release a prote...

Impact of Energy Production Proteins and Molecules in Triple-Negative Breast Cancer: Preclinical Findings

Synopsis Triple-negative breast cancer (TNBC) is a very aggressive cancer with few treatment options and a high ability to spread. This study found that TNBC cells use a process in their mitochond...

Nicotinamide Riboside Protects Against Doxorubicin-Induced Liver and Kidney Toxicity: Preclinical Findings

Synopsis Doxorubicin (DOX) is a powerful chemotherapy drug, but its use is limited because it causes serious liver and kidney toxicity through ferroptosis, an iron-dependent form of cell death dri...

Nicotinamide Riboside and Pyruvate Increase Anti-Inflammatory Pathways: Preclinical Findings

Synopsis This study uncovered a previously unknown anti-inflammatory metabolite, homocysitaconate, produced through the interaction of homocysteine and itaconate during inflammation. The enzyme S-...

Nicotinamide Riboside Restores NAD+ in RYR1-Related Muscle Diseases: Preclinical Findings

Synopsis Mutations in the RYR1 gene cause a group of rare congenital muscle diseases (RYR1-RM) characterized by problems in calcium regulation within muscle cells, leading to muscle weakness and f...

S-Adenosylmethionine and Nicotinamide Riboside Supplementation Improves Fatigue and Stabilizes Vision in PRPS1 Deficiency: Case Report

Objectives To evaluate the impact of S-Adenosylmethionine (SAMe) and NR supplementation on the clinical symptoms of PRPS1 deficiency, specifically focusing on fatigue, cognitive decline, and visio...

Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings

Objectives To evaluate whether combining aerobic exercise with NR could enhance blood pressure (BP) control in sedentary older adults with hypertension. Journal GeroScience Key Outcomes NR+Ex was...

Stem Cell Membrane–Coated Nanodrugs with Nicotinamide Riboside Targets Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a complex neurodegenerative disorder that urgently requires more effective, precisely targeted treatments. This study developed a biomimetic nanomedicine desig...

Reishi Mushroom Delays Kidney Aging Through Gut Microbiota and Nicotinamide Riboside: Preclinical Findings

Synopsis Ganoderma lucidum (G. lucidum), also known as Reishi mushroom, has been valued in traditional Chinese medicine (TCM) for its anti-aging and kidney-protective properties. This study explor...

Maternal Nicotinamide Riboside Supplementation During Pregnancy May Prevent KYNU Deficiency in Newborns: Case Report

Objectives To characterize the clinical, genetic, and biochemical features of KYNU deficiency and evaluate the safety and preliminary efficacy of postnatal nicotinamide and pyridoxine supplementat...

Nicotinamide Riboside Increases Stress Sensitivity and Alters Blood Cell Composition in Aging: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a precursor to NAD⁺, a key molecule for cellular energy that declines with age. Aging can cause reduced brain and immune function, changes in blood, and greate...

Is NAD+ a Key Factor in Ovarian Aging and Dysfunction? Current Insights and Uncertainties: Review

SynopsisRecent studies highlight NAD+ as a key player in energy metabolism, stress response, and aging, and boosting NAD+ may help treat female infertility. This review explores how NAD+ works in t...

Nicotinamide Riboside Restores Vascular Health in ACTA2 Mutation: Preclinical Findings

Synopsis Mutations in ACTA2 affecting arginine 179 cause early-onset strokes due to moyamoya-like artery blockages. This study found that mutant smooth muscle cells (SMCs) remain immature, highly ...

Nicotinamide Riboside Enhances Milk Production in Lactating Sows: Preclinical Findings

Synopsis Lactation insufficiency is a common challenge with unclear biological causes. This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, influences mammary g...

Nicotinamide Riboside Protects Against Heat Stress–Induced Testicular Damage and Improves Boar Fertility: Preclinical Findings

Synopsis Heat stress (HS) from rising global temperatures negatively affects male fertility, damaging the testes and reducing semen quality. This study examined how HS alters testicular NAD+ metab...

Role of NAD+ in Aging and Disease: Review

SynopsisNAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive declin...

Nicotinamide Riboside Enhances NK Cell Anti-Tumor Activity: Preclinical Findings

Synopsis Tumor-produced lactate weakens natural killer (NK) cells by causing lysine lactylation (Kla), disrupting NAD+ metabolism, and fragmenting mitochondria, which reduces cytotoxicity. Supplem...