The Effects of Nicotinamide Riboside on Color and Color Stability of Pork Chops: Preclinical Findings

SynopsisThis study tested whether nicotinamide riboside (NR) could improve the color and color stability of pork chops from pigs exposed to extreme stress before harvest. One hundred pigs received ...

Nicotinamide Riboside Helps Maintain Mitochondrial Health and Meat Quality in Pork: Preclinical Findings

SynopsisEarly postmortem muscle mitochondrial function and cell death affect pork quality, including color stability. This study tested whether nicotinamide riboside (NR) given to pigs before harve...

Effects of Nicotinamide, Pyridoxine, Nicotinamide Riboside, and Nicotinamide Mononucleotide on Muscle Stem Cells and Regeneration: Preclinical Findings

SynopsisSkeletal muscle depends on muscle stem cells (MuSCs) for growth and repair, but aging and muscle diseases reduce their function, leading to muscle loss and weakness. This study tested nicot...

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childho...

Nicotinamide Riboside Prevents Muscle Fatigue in Pigs: Preclinical Findings

SynopsisThis study tested how different doses of nicotinamide riboside (NR) affect muscle fatigue in pigs. One hundred barrows were fed diets with 0, 15, 30, or 45 mg NR per kg of body weight, or g...

In Ovo Nicotinamide Riboside Feeding Increases Muscle Mass and Fiber Number in Broiler Chickens: Preclinical Findings

SynopsisThis study examined the effects of in ovo nicotinamide riboside (NR) feeding on growth and meat quality in high-yield broilers. Fertilized Cobb 700 eggs were randomly assigned to four treat...

Effects of Nicotinamide Riboside on Spinal and Bulbar Muscular Atrophy (SBMA): Preclinical Findings

SynopsisPrevious studies have shown that in spinal and bulbar muscular atrophy (SBMA), a mutant protein called polyQ-expanded AR becomes improperly acetylated, and activating SIRT1, an NAD-dependen...

Nicotinamide Riboside Improves Insulin Resistance by Boosting Mitochondrial Function in Skeletal Muscle: Preclinical Findings

SynopsisHigh-fat diet-induced insulin resistance (IR) in skeletal muscle is linked to mitochondrial dysfunction and oxidative stress. This study assessed whether nicotinamide riboside (NR) could re...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Nicotinamide Riboside Restores Exercise Capacity and Mitochondrial Function in Barth Syndrome: Preclinical Findings

SynopsisBarth syndrome, caused by tafazzin mutation, leads to mitochondrial dysfunction and severe exercise intolerance. In a Drosophila model, NR supplementation restored exercise capacity and mit...

Nicotinamide Riboside Improves Mitochondrial Function and Exercise Ability in ANT1-Deficiency: Preclinical Findings

SynopsisMitochondrial disorders are often characterized by muscle weakness and fatigue. Mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) (or ANT1-deficiency) of both h...

Nicotinamide Riboside Injection Increases Muscle Growth in High-Yield Broiler Chickens: Preclinical Findings

SynopsisThis study investigated how injecting nicotinamide riboside (NR) into broiler chicken embryos affects breast muscle development. Injection site mattered: NR injected into the yolk sac incre...

In Ovo Feeding of Commercial Broiler Eggs: Preclinical Findings

SynopsisScientists have focused on improving muscle growth during early development because the number of muscle fibers formed before birth sets future growth potential. In poultry, feeding embryos...

Nicotinamide Riboside-Supplemented Diet Delays Muscle Degeneration in Mice Lacking the NAMPT Gene: Preclinical Findings

SynopsisNAD+ helps enzymes keep energy balanced in cells, and the enzyme NAMPT controls how NAD+ is made. NAD+ is important for healthy muscle, but how it affects muscle growth isn't fully clear. T...

Nicotinamide Riboside Improves Muscle Quality and Cellular Energy: Preclinical Findings

SynopsisNAD+, crucial for mitochondrial energy production, declines with age, potentially reducing physical performance. This study tested short-term NR supplementation in middle-aged mice and its ...

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

Activating the NRK Pathway Improves NAD+ Recycling in Muscle Disorders: Preclinical Findings

Synopsis Hexose-6-Phosphate Dehydrogenase (H6PD) produces NADPH inside the endoplasmic/sarcoplasmic reticulum (ER/SR), helping activate glucocorticoid hormones. However, its broader role in mainta...

Nicotinamide Riboside Administration Improves Mitophagy and Slows Aging in Werner Syndrome: Preclinical Findings

Synopsis Werner syndrome (WS) is a premature aging disease caused by mutations in the WRN gene, which affects DNA repair. WS patients show severe metabolic problems, but the causes are not fully c...

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone o...