Thiamine and Nicotinamide Riboside Improve Symptoms in Charcot-Marie-Tooth Neuropathy: Case Report

Objectives To identify the mechanistic basis of GDAP1 dysfunction in CMT2K and test whether targeted metabolic activation using thiamine and NR can therapeutically correct mitochondrial biochemica...

Comparative NAD-Boosting Efficacy of BluNADBooster (LN22199), Nicotinamide Riboside, and Their Combination in Healthy Aging Adults: Clinical Findings

Objectives To determine the effects of BluNADBooster (LN22199), NR, or their combination on blood NAD+ levels, CD38 activity, inflammatory markers, cognitive function, physical performance, and qu...

Nicotinamide Riboside Restores NAD+ in RYR1-Related Muscle Diseases: Preclinical Findings

Synopsis Mutations in the RYR1 gene cause a group of rare congenital muscle diseases (RYR1-RM) characterized by problems in calcium regulation within muscle cells, leading to muscle weakness and f...

The Effects of Nicotinamide Riboside on Color and Color Stability of Pork Chops: Preclinical Findings

SynopsisThis study tested whether nicotinamide riboside (NR) could improve the color and color stability of pork chops from pigs exposed to extreme stress before harvest. One hundred pigs received ...

Nicotinamide Riboside Helps Maintain Mitochondrial Health and Meat Quality in Pork: Preclinical Findings

SynopsisEarly postmortem muscle mitochondrial function and cell death affect pork quality, including color stability. This study tested whether nicotinamide riboside (NR) given to pigs before harve...

Effects of Nicotinamide, Pyridoxine, Nicotinamide Riboside, and Nicotinamide Mononucleotide on Muscle Stem Cells and Regeneration: Preclinical Findings

SynopsisSkeletal muscle depends on muscle stem cells (MuSCs) for growth and repair, but aging and muscle diseases reduce their function, leading to muscle loss and weakness. This study tested nicot...

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childho...

Nicotinamide Riboside Prevents Muscle Fatigue in Pigs: Preclinical Findings

SynopsisThis study tested how different doses of nicotinamide riboside (NR) affect muscle fatigue in pigs. One hundred barrows were fed diets with 0, 15, 30, or 45 mg NR per kg of body weight, or g...

In Ovo Nicotinamide Riboside Feeding Increases Muscle Mass and Fiber Number in Broiler Chickens: Preclinical Findings

SynopsisThis study examined the effects of in ovo nicotinamide riboside (NR) feeding on growth and meat quality in high-yield broilers. Fertilized Cobb 700 eggs were randomly assigned to four treat...

Effects of Nicotinamide Riboside on Spinal and Bulbar Muscular Atrophy (SBMA): Preclinical Findings

SynopsisPrevious studies have shown that in spinal and bulbar muscular atrophy (SBMA), a mutant protein called polyQ-expanded AR becomes improperly acetylated, and activating SIRT1, an NAD-dependen...

Clinical Outcomes of SAMe and Nicotinamide Riboside Supplementation in a Child with Arts Syndrome: Case Report

Objectives To examine the effects of supplementation of S-adenosylmethionine (SAMe) and NR in a child with Arts syndrome and compare to previous Arts syndrome patients who received SAMe with or wi...

Nicotinamide Riboside Improves Insulin Resistance by Boosting Mitochondrial Function in Skeletal Muscle: Preclinical Findings

SynopsisHigh-fat diet-induced insulin resistance (IR) in skeletal muscle is linked to mitochondrial dysfunction and oxidative stress. This study assessed whether nicotinamide riboside (NR) could re...

Effects of Nicotinamide Riboside in Hyperammonemia: Preclinical Findings

Synopsis Excess ammonia in the body disrupts metabolism and contributes to cellular aging (senescence) by damaging mitochondria and disturbing the NAD+/NADH redox balance, which is vital for energ...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Nicotinamide Riboside Restores Exercise Capacity and Mitochondrial Function in Barth Syndrome: Preclinical Findings

SynopsisBarth syndrome, caused by tafazzin mutation, leads to mitochondrial dysfunction and severe exercise intolerance. In a Drosophila model, NR supplementation restored exercise capacity and mit...

Nicotinamide Riboside and Pterostilbene Do Not Improve Muscle Recovery: Clinical Findings

Objectives To determine whether nicotinamide riboside and pterostilbene (NRPT) supplementation helps activate muscle stem cells and supports muscle repair after a small, controlled injury in elder...

Nicotinamide Riboside Improves Mitochondrial Function and Exercise Ability in ANT1-Deficiency: Preclinical Findings

SynopsisMitochondrial disorders are often characterized by muscle weakness and fatigue. Mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) (or ANT1-deficiency) of both h...

Nicotinamide Riboside Injection Increases Muscle Growth in High-Yield Broiler Chickens: Preclinical Findings

SynopsisThis study investigated how injecting nicotinamide riboside (NR) into broiler chicken embryos affects breast muscle development. Injection site mattered: NR injected into the yolk sac incre...

Effects of Intravenous Nicotinamide Riboside on Muscle NAD+: Preclinical Findings

Synopsis Although nicotinamide riboside (NR)—a common NAD+ booster—is believed to enhance energy metabolism, clinical studies have shown little effect on muscle function or insulin sensitivity. To...

In Ovo Feeding of Commercial Broiler Eggs: Preclinical Findings

SynopsisScientists have focused on improving muscle growth during early development because the number of muscle fibers formed before birth sets future growth potential. In poultry, feeding embryos...