Urolithin A and Nicotinamide Riboside Support Brain Immune Cells and Mitochondrial Health: Preclinical Findings

SynopsisDuring aging, many cellular processes, including DNA repair, energy production, and immune function, become less efficient. This study examined how two natural compounds, Urolithin A (UA) a...

Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

SynopsisPoly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial...

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

Nicotinamide Riboside Restores Mitochondrial Function in Alpers’ Syndrome: Preclinical Findings

SynopsisAlpers' syndrome is a devastating early-onset neurodegenerative disorder caused by POLG mutations impairing mitochondrial DNA replication. Patient-derived iPSCs were used to create brain or...

Nicotinamide Riboside Restores Mitochondrial Function and Improves Heart Failure with Preserved Ejection Fraction: Preclinical Findings

SynopsisHeart Failure with Preserved Ejection Fraction (HFpEF) is a serious heart condition without effective treatments. In a mouse model of HFpEF, researchers found impaired mitochondrial fatty a...

Nicotinamide Riboside Rejuvenates Aged Hematopoietic Stem Cells and Improves Regeneration: Preclinical Findings

SynopsisWith age, hematopoietic stem cells (HSCs) lose their ability to regenerate and remain quiescent, leading to an expanded stem cell pool that can cause blood disorders. Researchers found that...

Nicotinamide Riboside Protects Liver Immune Cells from Alcohol-Induced Damage: Preclinical Findings

SynopsisAlcohol-related liver disease (ALD) is linked to mitochondrial dysfunction and impaired energy metabolism. This study examined how ethanol damages Kupffer cells, the liver's resident immune...

Nicotinamide Riboside Protects CD8+ T Cells From Exhaustion by Improving Mitochondrial Health: Preclinical Findings

SynopsisProtecting mitochondria in CD8+ T cells is important for improving cancer immunotherapy. This study tested whether nicotinamide riboside (NR) could prevent T cell exhaustion. In lab models,...

Nicotinamide Riboside Prevents Liver Injury and Restores Mitochondrial Function: Preclinical Findings

SynopsisNAMPT is an enzyme that helps make NAD+. Since low liver NAD+ is linked to fatty liver disease, scientists removed NAMPT specifically from liver cells in mice to see the effect. These mice ...

Nicotinamide Riboside Preserves Retinal Cells and Mitochondrial Function in Glucocorticoid-Induced Glaucomae: Preclinical Findings

SynopsisGlucocorticoid-induced glaucoma (GIG) is a common side effect of steroid use that can cause blindness by damaging the eye's trabecular meshwork (TM), raising eye pressure, and killing retin...

Nicotinamide Riboside Improves Mitophagy and Reduces Neuroinflammation in Ataxia Telangiectasia: Preclinical Findings

SynopsisIn the premature aging disease ataxia telangiectasia (A-T), cells show mitochondrial dysfunction and a senescence state that causes inflammation (SASP). This is linked to buildup of damaged...

Nicotinamide Riboside Improves Mitochondrial Health in Werner Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) is a rare accelerated aging disease caused by mutations in the WRN gene, leading to metabolic problems and premature cell aging. This study found that loss of WRN incre...

Nicotinamide Riboside Improves Mitochondrial Function and Survival Post-Heart Attack: Preclinical Findings

SynopsisMyocardial infarction (MI), or heart attack, is a leading cause of death, and reduced NAD+ levels in the heart can worsen damage after MI. This study tested whether nicotinamide riboside (N...

Nicotinamide Riboside Improves Mitochondrial Function and Exercise Ability in ANT1-Deficiency: Preclinical Findings

SynopsisMitochondrial disorders are often characterized by muscle weakness and fatigue. Mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) (or ANT1-deficiency) of both h...

Nicotinamide Riboside Helps Maintain Mitochondrial Health and Meat Quality in Pork: Preclinical Findings

SynopsisEarly postmortem muscle mitochondrial function and cell death affect pork quality, including color stability. This study tested whether nicotinamide riboside (NR) given to pigs before harve...

Nicotinamide Riboside and Metformin Restore Mitochondrial Function: Preclinical Findings

SynopsisMitophagy is the process cells use to clear damaged mitochondria, keeping cells healthy. Defects in this process are linked to neurodegenerative diseases. Using stem cell–derived brain cell...

NAD+ Precursors Restore Mitophagy and Reverse Aging Markers: Preclinical Findings

SynopsisSelective removal of damaged mitochondria (mitophagy) is crucial for cell health. Human cells show active basal mitophagy, mediated by the PINK1/Parkin pathway and p62 as a receptor. Mitoph...

Mitochondrial Targeting Inhibits Breast Cancer Stem Cells: Preclinical Findings

SynopsisMitochondria are vital cell components that generate energy, build essential molecules, and support cell signaling. In cancer, mitochondria often adapt to fuel tumor growth by supplying the...

Mitochondrial Activators Like Nicotinamide Riboside Help Heart Cell Function: Preclinical Findings

SynopsisMitochondrial dysfunction in failing hearts can cause energy shortages in heart cells. This study tested how isoproterenol (ISO), a compound that stresses heart cells, affects mitochondria ...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...