Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS). Journal Aging Cell Key Outcomes NR improved arterial stiffness, as measured by the...

Nicotinamide Riboside Restores Mitochondrial Function in Aortic Aneurysms: Preclinical Findings

Synopsis Thoracic aortic aneurysms (TAA) are deadly vascular disorders linked to genetic mutations such as ACTA2R179H and TGFBR2G357W, which disrupt vascular smooth muscle cell (VSMC) function. Th...

Nicotinamide Riboside and NMN Enhance CAR-T Cell Function in Aging: Preclinical Findings

Synopsis Chimeric antigen receptor (CAR) T cell therapy is a powerful cancer treatment, but its effectiveness declines with aging. This study found that CAR-T cells from aged female mice show mito...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...

Nicotinamide Riboside Improves Vascular and Cognitive Health in Peripheral Artery Disease: Clinical Findings

Objectives To investigate the potential for NR to counteract the age-related vascular and cognitive decline in peripheral artery disease (PAD) patients. Journal The Journal of Pharmacology and Exp...

Nicotinamide Riboside Reduces Kidney Damage in Chronic Disease: Preclinical Findings

Synopsis Subclinical chronic kidney disease (sCKD) increases vulnerability to acute kidney injury (AKI). In a rat model where ischemia–reperfusion injury (IRI) was applied on top of sCKD, a dual t...

Nicotinamide Riboside Protects the Intestinal Barrier From Heat Stress: Preclinical Findings

Synopsis Heat stress damages the intestinal epithelial barrier, allowing harmful substances to enter the body. This study tested whether nicotinamide riboside (NR), a NAD+ precursor, could protect...

Nicotinamide Riboside Restores Mitochondrial Activity and Thermogenesis in Brown Fat: Preclinical Findings

Synopsis Brown adipose tissue (BAT) depends on NAD+ biosynthesis for healthy mitochondrial function and thermogenesis. Multi-omics analysis of BXD mouse strains showed that BAT NAD+ metabolism str...

Safety of Intravenous Nicotinamide Riboside Across Multiple Doses in Rats: Preclinical Findings

Synopsis This study evaluated the safety of repeated intravenous nicotinamide riboside (NR) at varying doses in Wistar rats. NR was well-tolerated at 150, 300, and 450 mg/kg, with no adverse effec...

Nicotinamide Riboside Protects Against Doxorubicin Cardiotoxicity: Preclinical Findings

Synopsis In human iPSC-derived cardiomyocytes, nicotinamide riboside (NR) improved mitochondrial fusion, enhanced oxidative phosphorylation and ATP production, and upregulated ERRα, a key metaboli...

NAD+ Augmentation as a Disease-Modifying Strategy for Neurodegeneration: Review

SynopsisNeurodegenerative diseases are a growing global health problem with no current treatments that slow or stop their progression. Boosting nicotinamide adenine dinucleotide (NAD+) has emerged ...

Nicotinamide Riboside Prevents Oocyte Quality Loss in Maternal Diabetes: Preclinical Findings

Synopsis Diabetes reduces NAD+ levels in ovaries and oocytes, leading to poor oocyte quality, abnormal spindle formation, excess ROS, and impaired embryo development. In streptozotocin-induced dia...

Mixed-Mode LC-MS Method Quantifies NAD+ and Its Metabolites: Preclinical Findings

Synopsis Measuring NAD+ and its metabolites is technically difficult because these molecules are highly polar and poorly retained by standard chromatography. This study developed a robust mixed-mo...

Combined Metabolic Activators Improve Brain and Liver Function in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial dysfunction and metabolic problems are major contributors to neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). Research shows that combined metabolic...

Nicotinamide Riboside Alleviates Bone Cancer Pain by Restoring Mitochondrial Function: Preclinical Findings

Synopsis Bone cancer pain (BCP) disrupts mitochondrial function in spinal cord neurons, leading to damaged mitochondrial structure, reduced ATP production, and decreased membrane potential (MMP). ...

Nicotinamide Riboside Restores Lipid Handling in Diabetic Heart Disease: Preclinical Findings

Synopsis Excessive lipid droplet buildup and lipotoxicity contribute to diabetic cardiomyopathy (DCM). This study found that lipophagy—the autophagic breakdown of lipid droplets—is impaired in DCM...

NAD+ Restores Heart Function in Heart Failure via Ketone Production: Preclinical Findings

Synopsis Heart failure with preserved ejection fraction (HFpEF) is a common form of heart failure with few treatment options. This study found that the heart can make ketones using the enzyme HMGC...

Nicotinamide Riboside Reduces Inflammation in Retinal Degeneration: Preclinical Findings

Synopsis Bright light exposure triggers mitochondrial damage in the retina, releasing double-stranded DNA that activates the cGAS-STING inflammatory pathway and drives microglial pyroptosis, accel...

The Effects of Boosting NAD+ on Atherosclerosis and Inflammation: Preclinical Findings

SynopsisNAD+ is a key molecule that activates sirtuins, which are linked to benefits like lifespan extension and improved metabolism in mice. Supplements like nicotinamide riboside (NR) are used to...

Nicotinamide Riboside Improves Mitochondrial Health in Werner Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) is a rare accelerated aging disease caused by mutations in the WRN gene, leading to metabolic problems and premature cell aging. This study found that loss of WRN incre...