Nicotinamide Riboside and Pyruvate Increase Anti-Inflammatory Pathways: Preclinical Findings

Synopsis This study uncovered a previously unknown anti-inflammatory metabolite, homocysitaconate, produced through the interaction of homocysteine and itaconate during inflammation. The enzyme S-...

Nicotinamide Riboside Restores NAD+ in RYR1-Related Muscle Diseases: Preclinical Findings

Synopsis Mutations in the RYR1 gene cause a group of rare congenital muscle diseases (RYR1-RM) characterized by problems in calcium regulation within muscle cells, leading to muscle weakness and f...

S-Adenosylmethionine and Nicotinamide Riboside Supplementation Improves Fatigue and Stabilizes Vision in PRPS1 Deficiency: Case Report

Objectives To evaluate the impact of S-Adenosylmethionine (SAMe) and NR supplementation on the clinical symptoms of PRPS1 deficiency, specifically focusing on fatigue, cognitive decline, and visio...

Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings

Objectives To evaluate whether combining aerobic exercise with NR could enhance blood pressure (BP) control in sedentary older adults with hypertension. Journal GeroScience Key Outcomes NR+Ex was...

Stem Cell Membrane–Coated Nanodrugs with Nicotinamide Riboside Targets Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a complex neurodegenerative disorder that urgently requires more effective, precisely targeted treatments. This study developed a biomimetic nanomedicine desig...

Reishi Mushroom Delays Kidney Aging Through Gut Microbiota and Nicotinamide Riboside: Preclinical Findings

Synopsis Ganoderma lucidum (G. lucidum), also known as Reishi mushroom, has been valued in traditional Chinese medicine (TCM) for its anti-aging and kidney-protective properties. This study explor...

Maternal Nicotinamide Riboside Supplementation During Pregnancy May Prevent KYNU Deficiency in Newborns: Case Report

Objectives To characterize the clinical, genetic, and biochemical features of KYNU deficiency and evaluate the safety and preliminary efficacy of postnatal nicotinamide and pyridoxine supplementat...

Nicotinamide Riboside Increases Stress Sensitivity and Alters Blood Cell Composition in Aging: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a precursor to NAD⁺, a key molecule for cellular energy that declines with age. Aging can cause reduced brain and immune function, changes in blood, and greate...

Is NAD+ a Key Factor in Ovarian Aging and Dysfunction? Current Insights and Uncertainties: Review

SynopsisRecent studies highlight NAD+ as a key player in energy metabolism, stress response, and aging, and boosting NAD+ may help treat female infertility. This review explores how NAD+ works in t...

Nicotinamide Riboside Restores Vascular Health in ACTA2 Mutation: Preclinical Findings

Synopsis Mutations in ACTA2 affecting arginine 179 cause early-onset strokes due to moyamoya-like artery blockages. This study found that mutant smooth muscle cells (SMCs) remain immature, highly ...

Nicotinamide Riboside Enhances Milk Production in Lactating Sows: Preclinical Findings

Synopsis Lactation insufficiency is a common challenge with unclear biological causes. This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, influences mammary g...

Nicotinamide Riboside Protects Against Heat Stress–Induced Testicular Damage and Improves Boar Fertility: Preclinical Findings

Synopsis Heat stress (HS) from rising global temperatures negatively affects male fertility, damaging the testes and reducing semen quality. This study examined how HS alters testicular NAD+ metab...

Role of NAD+ in Aging and Disease: Review

SynopsisNAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive declin...

Nicotinamide Riboside Enhances NK Cell Anti-Tumor Activity: Preclinical Findings

Synopsis Tumor-produced lactate weakens natural killer (NK) cells by causing lysine lactylation (Kla), disrupting NAD+ metabolism, and fragmenting mitochondria, which reduces cytotoxicity. Supplem...

Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS). Journal Aging Cell Key Outcomes NR improved arterial stiffness, as measured by the...

Nicotinamide Riboside Restores Mitochondrial Function in Aortic Aneurysms: Preclinical Findings

Synopsis Thoracic aortic aneurysms (TAA) are deadly vascular disorders linked to genetic mutations such as ACTA2R179H and TGFBR2G357W, which disrupt vascular smooth muscle cell (VSMC) function. Th...

Nicotinamide Riboside and NMN Enhance CAR-T Cell Function in Aging: Preclinical Findings

Synopsis Chimeric antigen receptor (CAR) T cell therapy is a powerful cancer treatment, but its effectiveness declines with aging. This study found that CAR-T cells from aged female mice show mito...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...

Nicotinamide Riboside Improves Vascular and Cognitive Health in Peripheral Artery Disease: Clinical Findings

Objectives To investigate the potential for NR to counteract the age-related vascular and cognitive decline in peripheral artery disease (PAD) patients. Journal The Journal of Pharmacology and Exp...

Nicotinamide Riboside Reduces Kidney Damage in Chronic Disease: Preclinical Findings

Synopsis Subclinical chronic kidney disease (sCKD) increases vulnerability to acute kidney injury (AKI). In a rat model where ischemia–reperfusion injury (IRI) was applied on top of sCKD, a dual t...