Article: Nicotinamide Riboside Has Minor Effect on Energy Metabolism in Obesity: Preclinical Findings

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Metabolic Health Obesity Preclinical

Nicotinamide Riboside Has Minor Effect on Energy Metabolism in Obesity: Preclinical Findings

Synopsis

NR has been shown to reverse obesity-related health issues in mice, but effects may vary by strain. Researchers compared mildly obese C57BL/6N and C57BL/6J mice on high-fat diets, with or without NR for 8 weeks. NR didn't affect body weight, fat accumulation, glucose metabolism, or energy use, but it did increase mitochondrial activity in one muscle type in both strains. The two strains showed differences in fat storage, blood sugar, and energy use, but NR's metabolic benefits were limited in this mild obesity setting.

Journal

The Journal of Endocrinology

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Autoimmune Disease

Nicotinamide Riboside Helps Improve Symptoms in Lupus: Preclinical Findings

SynopsisThe protein PPP2R2A helps regulate the immune system, and in lupus-prone mice, T cells lacking this protein caused less autoimmunity and kidney damage. Without PPP2R2A, T cells produced mor...

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Metabolic Health

Nicotinamide Riboside Has Minor Metabolic Benefits in Obesity: Preclinical Findings

SynopsisNicotinamide riboside supplements (NRS) are thought to boost NAD+ levels and mitochondrial function, potentially improving muscle health and energy use. This study tested NRS effects in nor...

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