Roseburia hominis and Nicotinamide Riboside Combat Obesity: Preclinical Findings

Synopsis The gut bacterium Roseburia hominis was found to be depleted in obese individuals and negatively correlated with BMI and serum triglycerides. In high-fat diet–fed mice, supplementation wi...

The Effects of Nicotinamide Riboside on Color and Color Stability of Pork Chops: Preclinical Findings

SynopsisThis study tested whether nicotinamide riboside (NR) could improve the color and color stability of pork chops from pigs exposed to extreme stress before harvest. One hundred pigs received ...

Natural Nicotinamide Riboside–Loaded Stem Cell Extracellular Vesicles Synergistically Combat Aging: Preclinical Findings

Synopsis This study explored the potential of small extracellular vesicles (ASC-sEVs) from adipose-derived stem cells for skin care and anti-aging. Researchers purified ASC-sEVs and analyzed their...

Nicotinamide Riboside Counteracts Testicular Aging: Preclinical Findings

Synopsis Deleting Qprt, a key enzyme in the NAD+ de novo synthesis pathway and highly expressed in spermatocytes, did not disrupt NAD+ levels or spermatogenesis in young (3-month-old) mice. Howeve...

Mitochondrial Activators Like Nicotinamide Riboside Help Heart Cell Function: Preclinical Findings

SynopsisMitochondrial dysfunction in failing hearts can cause energy shortages in heart cells. This study tested how isoproterenol (ISO), a compound that stresses heart cells, affects mitochondria ...

CD38 Converts NMN to NaMN Through Base Exchange: Preclinical Findings

Synopsis Nicotinamide mononucleotide (NMN) is generally assumed to boost NAD+ by feeding directly into the canonical salvage pathway. However, this study shows that NMN treatment unexpectedly incr...

Nicotinamide Riboside Protects Liver Cells from Palmitate-Induced Damage: Preclinical Findings

Synopsis This study examined how excessive fat buildup in liver cells (hepatic lipotoxicity) contributes to liver damage, a key factor in metabolic liver diseases. Researchers found that exposure ...

Nicotinamide Riboside Mitigates Diabetes-Related Bone Loss: Preclinical Findings

Synopsis Type 2 diabetes mellitus (T2DM) caused by high-fat diet/streptozotocin treatment led to impaired bone microarchitecture and bone loss in mice, along with metabolic dysfunction. Supplement...

Nicotinamide Riboside Supplementation Reduces Oxidative Stress and Enhances Mitochondrial Function in Chronic Kidney Disease Immune Cells: Clinical Findings

Objectives To investigate the effects of NR and CoQ10 on oxidative stress, inflammation, and mitochondrial function in patients with chronic kidney disease (CKD). Journal Clinical Journal of the A...

Nicotinamide Riboside Reduces Sweetener-Induced Neurocognitive Impairments: Preclinical Findings

Synopsis Around the world, many people consume sweeteners, with sweet beverages being a major source. Previous studies have shown that too many sweeteners can harm health, including affecting brai...

Nicotinamide Riboside Improves Ovarian Function in PCOS: Preclinical Findings

Synopsis In a DHEA-induced mouse model of polycystic ovary syndrome (PCOS), ovarian NAD+ levels dropped sharply, leading to mitochondrial dysfunction in granulosa cells, stromal cells, and oocytes...

Nicotinamide Riboside Supplementation Improves Alzheimer's Biomarkers in Subjective Cognitive Decline and Mild Cognitive Impairment: Clinical Findings

Objectives To test the safety and efficacy of oral NR supplementation on cognition and Alzheimer's disease (AD) blood biomarkers in older adults with subjective cognitive decline and mild cognitiv...

NR and Inosine Restore Metabolic Activity in NAXD-Deficient Cells: Preclinical Findings

Synopsis Mutations in the metabolite-repair enzyme NAXD, which normally converts damaged NADHX/NADPHX back into functional cofactors, cause the severe neurometabolic disorder PEBEL2. In human NAXD...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...

Nicotinamide Riboside Helps Maintain Mitochondrial Health and Meat Quality in Pork: Preclinical Findings

SynopsisEarly postmortem muscle mitochondrial function and cell death affect pork quality, including color stability. This study tested whether nicotinamide riboside (NR) given to pigs before harve...

Nicotinamide Riboside Supplementation with Metabolic Activators Improves Cognitive Function in Parkinson’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of NR, L-carnitine tartrate, serine, and N-acetyl-L-cysteine (NAC), could be used to treat Parki...

Nicotinamide Riboside Blocks LPS-Induced Microglial Inflammation: Preclinical Findings

Synopsis In LPS-stimulated BV2 microglia, nicotinamide riboside (NR) restored mitochondrial function and reduced inflammation by activating the AMPK–SIRT3 signaling axis. NR shifted microglia from...

Nicotinamide Riboside Protects Bones via Mitochondrial Support: Preclinical Findings

Synopsis This study uncovered how gut microbiota imbalances contribute to osteoporosis through the overproduction of trimethylamine-N-oxide (TMAO), a metabolite formed from L-carnitine by intestin...

Nicotinamide Riboside Protects Liver Immune Cells from Alcohol-Induced Damage: Preclinical Findings

SynopsisAlcohol-related liver disease (ALD) is linked to mitochondrial dysfunction and impaired energy metabolism. This study examined how ethanol damages Kupffer cells, the liver's resident immune...

Urolithin A and Nicotinamide Riboside Support Brain Immune Cells and Mitochondrial Health: Preclinical Findings

SynopsisDuring aging, many cellular processes, including DNA repair, energy production, and immune function, become less efficient. This study examined how two natural compounds, Urolithin A (UA) a...