Article: Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

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Alzheimer's Disease Metabolic Health Neurological Health Preclinical

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

Synopsis

SIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resistance and amyloid plaque buildup. This study found that loss of SIRT3 lowers insulin-degrading enzyme (IDE) levels, which normally clears insulin and amyloid-beta peptides. A Western diet reduced IDE and SIRT3 levels in AD mice. Boosting SIRT3 with nicotinamide riboside increased IDE and another amyloid-clearing enzyme (neprilysin), while reducing an enzyme that produces amyloid (BACE1). This suggests SIRT3 helps protect against AD by regulating key enzymes involved in insulin and amyloid clearance.

Journal

Scientific Reports

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Digestive/Gut Health

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