Article: Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings

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Inflammation Metabolic Health Obesity Preclinical

Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings

Synopsis

NR supplementation was tested in young and old obese female mice to see if it reduces liver inflammation and fibrosis. In old mice, NR decreased weight gain, fat mass, and improved glucose tolerance and cholesterol levels. Although it did not reduce liver fat or fibrosis, NR significantly reduced inflammation and fibrosis in fat tissue and increased metabolism and activity. NR had little effect in young mice. These results indicate NR may help prevent obesity-related fat tissue damage in older females.

Journal

The Journal of Nutritional Biochemistry

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Diabetes

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

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Neurological Health

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

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