Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings
Synopsis
NR supplementation was tested in young and old obese female mice to see if it reduces liver inflammation and fibrosis. In old mice, NR decreased weight gain, fat mass, and improved glucose tolerance and cholesterol levels. Although it did not reduce liver fat or fibrosis, NR significantly reduced inflammation and fibrosis in fat tissue and increased metabolism and activity. NR had little effect in young mice. These results indicate NR may help prevent obesity-related fat tissue damage in older females.
Journal
The Journal of Nutritional Biochemistry