Nicotinamide Riboside: Review

SynopsisNicotinamide riboside (NR) is a well-studied NAD+ precursor with multiple health benefits linked to increasing NAD+ levels in the body. Studies in animals and humans show NR may help treat ...

Nicotinamide Riboside and Resveratrol Enhance Wound Healing in Diabetic Rats: Preclinical Findings

Synopsis Diabetes impairs wound healing by disrupting autophagy and promoting apoptosis. In a type 1 diabetic rat model, systemic and topical nicotinamide riboside (NR) and resveratrol (RSV) signi...

Nicotinamide Riboside Improves Fructose-Induced Lipid Metabolism Disorders: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, protects against fat metabolism disorders caused by high fructose intake. Mice given a 20% fructose ...

Nicotinamide Riboside Reduces Airway Inflammation in COPD: Clinical Findings

Objectives To investigate the effects of NR supplementation on airway inflammation and cellular senescence in previously smoking patients with chronic obstructive pulmonary disease (COPD). Journal...

Effects of Nicotinamide, Pyridoxine, Nicotinamide Riboside, and Nicotinamide Mononucleotide on Muscle Stem Cells and Regeneration: Preclinical Findings

SynopsisSkeletal muscle depends on muscle stem cells (MuSCs) for growth and repair, but aging and muscle diseases reduce their function, leading to muscle loss and weakness. This study tested nicot...

NR Restores Mitochondrial Function and Reduces Trigeminal Pain: Preclinical Findings

Synopsis In a mouse model of trigeminal neuropathic pain, the injured trigeminal ganglion (TG) showed profound mitochondrial dysfunction, affecting gene expression, protein synthesis, and respirat...

Nicotinamide Riboside Protects Dopamine Neurons in Parkinson's Disease: Preclinical Findings

Synopsis This study identified the essential role of NAMPT, an enzyme that helps produce NAD+, in protecting dopaminergic neurons—the brain cells that control movement and are lost in Parkinson’s ...

Standardized Assay Quantifies NAD+ and NADH in Worms, Mice, and Human Blood: Preclinical Findings

SynopsisA standardized assay was developed to measure NAD+, NADH, and the NAD+/NADH ratio across multiple biological samples, including C. elegans, mouse muscle, mouse blood, and human blood. The p...

Nicotinamide Riboside Protects Brain Development from Drug Toxicity: Preclinical Findings

Synopsis This study explored the potential neurodevelopmental risks of oseltamivir phosphate (OSE)—a widely used antiviral drug also found in the environment—using zebrafish models. Researchers di...

Nicotinamide Riboside Inhibits CD38 in Living Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy production, metabolism, and cell signaling, but its levels naturally decline with age and disease. One key reason for this...

Nicotinamide Riboside Preserves Oocyte Quality and Prevents Postovulatory Aging: Preclinical Findings

Synopsis After ovulation, oocytes (eggs) begin to age, leading to lower fertilization success and embryo quality during assisted reproductive technologies (ART) such as IVF. This process, known as...

Nicotinamide Riboside Protects CD8+ T Cells From Exhaustion by Improving Mitochondrial Health: Preclinical Findings

SynopsisProtecting mitochondria in CD8+ T cells is important for improving cancer immunotherapy. This study tested whether nicotinamide riboside (NR) could prevent T cell exhaustion. In lab models,...

Ketone Utilization in Heart and Kidney Metabolism with D-βHB Supplementation: Clinical Findings

Objectives To investigate how the heart and kidneys use ketones as an energy source in healthy subjects after short-term fasting (fasted), a Boost® liquid meal (fed), and with or without the consu...

Nicotinamide Riboside Protects Retinal Ganglion Cells: Preclinical Findings

Synopsis Glaucoma causes vision loss by damaging retinal ganglion cells (RGCs)—the neurons that carry visual information to the brain. One key cause of this damage is glutamate excitotoxicity, whe...

NAD+ Depletion Is Central to Placental Dysfunction in an Inflammatory Subclass of Preeclampsia: Preclinical Findings

Synopsis Preeclampsia (PE) is a dangerous pregnancy complication marked by high blood pressure, inflammation, and placental dysfunction, leading to serious risks for both mother and baby. This stu...

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childho...

Low NMNAT2 Triggers SARM1 Activity and Alters Nicotinamide Riboside Response in Axons: Preclinical Findings

SynopsisNMNAT2 is a key protein that keeps axons healthy by blocking the pro-degenerative protein SARM1. Completely losing NMNAT2 in mice causes severe axon loss and early death, but removing SARM1...

Effects of Nicotinamide Riboside on Hearing: Preclinical Findings

Synopsis This study examined how repeated high-dose intravenous nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—affects hearing in Wistar rats. Researchers measured the activity of bo...

Nicotinamide Riboside Enhances T Cell Function and Antitumor Immunity: Preclinical Findings

Synopsis Most current cancer immunotherapies mainly focus on activating type 1 immune responses, which help fight cancer, but long-term remission is rare. Our study shows that a type 2 immune prot...

Nicotinamide Riboside Prevents Cardiac Death: Preclinical Findings

Synopsis This study revealed that maintaining NAD+ levels is critical for heart health and rhythm stability. Researchers found that when Nampt, the key enzyme responsible for NAD+ production, was ...