Nicotinamide Riboside Supplementation May Influence Bacterial Composition: Clinical Findings

Objectives To explore the effects of NR supplementation on the gut microbiota composition in humans. Journal npj Aging Key Outcomes NR supplementation did not affect the diversity or abundance of...

Metabolic Engineering of E. coli Enables Efficient Biosynthesis of Nicotinamide Riboside: Preclinical Findings

Synopsis Researchers developed a highly efficient biotechnological method to produce nicotinamide riboside (NR)—a vital precursor of NAD+—using engineered E. coli bacteria. They identified that th...

Nicotinamide Riboside Slows Liver Cancer Growth and Metastasis: Preclinical Findings

SynopsisNicotinamide adenine dinucleotide (NAD+) metabolism has emerged as a target in cancer treatment. This study evaluated the effects of nicotinamide riboside (NR), a NAD+ precursor, on hepatoc...

Nicotinamide Riboside Supplementation Does Not Disrupt Methylation, Including in Individuals with MTHFR Mutations: Clinical Findings

Objectives To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (P...

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

SynopsisDiabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using...

Nicotinamide Riboside and Nicotinamide Mononucleotide Protect Against Kidney Injury: Preclinical Findings

Synopsis This study uncovered how NAD+ deficiency contributes to kidney disease by damaging mitochondria and triggering inflammation. Through metabolic analysis of human kidney samples, researcher...

Nicotinamide Riboside Corrects Metabolic Imbalances and Mitochondrial Dysfunction in Citrin Deficiency: Preclinical Findings

SynopsisCitrin deficiency (CD) is a genetic metabolic disorder caused by loss of the mitochondrial transporter CITRIN, which plays a role in the urea cycle and malate–aspartate shuttle. Patients wi...

Nicotinamide Riboside Supplementation Improves Fetal Growth Under Hypoglycemia: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 known for its metabolic benefits, may play an important role in glucose control during pregnancy. This study examined how NR affects blood...

Nicotinamide Riboside and Calorie Restriction Improve Gut Microbiota and Reduce Liver Fat and Inflammation: Preclinical Findings

SynopsisMetabolic dysfunction–related fatty liver disease currently has no specific therapy. This study tested nicotinamide riboside (NR) and dietary restriction (DR) in rats with diet-induced obes...

Nicotinamide Riboside Supplementation Partially Restores Sense of Smell in Aging: Preclinical Findings

SynopsisLoss of smell is an early and common feature of both aging and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated behavioral and molecular changes in th...

Nicotinamide Riboside Boosts NAD+ to Improve Telomere Stability: Preclinical Findings

SynopsisTelomere biology disorders (TBDs), such as dyskeratosis congenita (DC), are characterized by critically short telomeres and often lead to bone marrow failure. A key metabolic molecule, NAD+...

Timing of NAD+ Precursors Determines Neuroprotection After Stroke: Preclinical Findings

Synopsis Researchers studying nicotinamide riboside (NR) and nicotinamide (NAM)—both vitamin B3-based NAD+ boosters—found that the timing of supplementation plays a critical role in brain recovery...

Beyond Pellagra—NAD+ Deficiency in Aging and Disease: Review

SynopsisInterest in NAD+ has surged because low NAD+ levels are linked to many health problems, including metabolic diseases, neurodegeneration, reproductive disorders, cancer, and aging. Researche...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Nicotinamide Riboside Restores NAD+ and Counters Tumor Hyperprogression: Preclinical Findings

Synopsis Immune checkpoint blockade (ICB) therapy can sometimes cause tumors to grow faster, a problem called hyperprogressive disease (HPD). This study found that when immune cells release interf...

Nicotinamide Riboside Maintains Mitochondrial Health in Intervertebral Disc Degeneration: Preclinical Findings

Synopsis This study explored how the mitochondrial unfolded protein response (UPRmt) protects cells in the intervertebral disc from damage by activating mitophagy, the process that clears defectiv...

Nicotinamide Riboside Protects Intestinal Barrier From Alcohol Damage by Supporting Mitochondrial Function: Preclinical Findings

SynopsisThe intestinal barrier, made up of epithelial tight junctions, prevents harmful substances in the gut from entering the bloodstream. When this barrier is damaged, it can cause widespread in...

Combined Metabolic Activators Including Nicotinamide Riboside Improve Metabolism in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are linked to metabolic problems, including mitochondrial dysfunction. This study analyzed human brai...

Nicotinamide Riboside Supplementation Raises NAD+ and Lowers Alzheimer's-Associated Biomarkers: Clinical Findings

Objectives To evaluate if NR could augment neuronal NAD+ levels and impact markers of neurodegeneration and insulin-signaling in plasma-derived human neuronal extracellular vesicles (NEVs). Journa...