Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Nicotinamide Riboside Restores NAD+ and Counters Tumor Hyperprogression: Preclinical Findings

Synopsis Immune checkpoint blockade (ICB) therapy can sometimes cause tumors to grow faster, a problem called hyperprogressive disease (HPD). This study found that when immune cells release interf...

Nicotinamide Riboside Maintains Mitochondrial Health in Intervertebral Disc Degeneration: Preclinical Findings

Synopsis This study explored how the mitochondrial unfolded protein response (UPRmt) protects cells in the intervertebral disc from damage by activating mitophagy, the process that clears defectiv...

Nicotinamide Riboside Protects Intestinal Barrier From Alcohol Damage by Supporting Mitochondrial Function: Preclinical Findings

SynopsisThe intestinal barrier, made up of epithelial tight junctions, prevents harmful substances in the gut from entering the bloodstream. When this barrier is damaged, it can cause widespread in...

Combined Metabolic Activators Including Nicotinamide Riboside Improve Metabolism in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are linked to metabolic problems, including mitochondrial dysfunction. This study analyzed human brai...

Nicotinamide Riboside Supplementation Raises NAD+ and Lowers Alzheimer's-Associated Biomarkers: Clinical Findings

Objectives To evaluate if NR could augment neuronal NAD+ levels and impact markers of neurodegeneration and insulin-signaling in plasma-derived human neuronal extracellular vesicles (NEVs). Journa...

Nicotinamide Riboside Improved Mood and Behavior in Depression: Preclinical Findings

Synopsis This study found that low levels of NAD+, a molecule essential for brain energy and cell function, may contribute to depression-like symptoms. Mice with reduced activity of the enzyme NAM...

Host Nicotinamide Feeds Gut Microbiome to Support NAD+ Metabolism: Preclinical Findings

Synopsis Researchers found that gut bacteria play an important role in how the body produces NAD+, a molecule that helps cells create energy and stay healthy. When we eat vitamin B3 forms like nic...

Mitochondrial PARP1 Regulates Mitochondrial DNA and Aging: Preclinical Findings

Synopsis Scientists have discovered that the enzyme PARP1, known for repairing DNA in the cell nucleus, is also active inside mitochondria, where it helps control mitochondrial DNA (mtDNA). Using ...

Nicotinamide Riboside Supplementation Improves Post-Ovulatory Oocyte Quality: Preclinical Findings

Synopsis As eggs age after ovulation, their quality declines, reducing the chances of successful fertilization and embryo development during assisted reproductive technology (ART) procedures like ...

Combination of Metabolic Cofactors and Nicotinamide Riboside Reduces Obesity and Insulin Resistance: Preclinical Findings

SynopsisObesity is a global health problem marked by excessive fat that often leads to metabolic issues like insulin resistance, high blood pressure, abnormal cholesterol levels, and metabolic synd...

Nicotinamide Riboside and Pterostilbene Reduce Liver Inflammation in NAFLD: Clinical Findings

Objectives To determine the effects of nicotinamide riboside and pterostilbene (NRPT) supplementation on liver fat in adults with non-alcoholic fatty liver disease (NAFLD). Journal Hepatology Key ...

Autophagy Promotes Cell Survival by Maintaining Stable NAD+ Levels: Preclinical Findings

SynopsisAutophagy is a cellular process that removes damaged parts of the cell and is important for healthy aging. When autophagy is lost, NAD+ levels fall due to increased activity of enzymes that...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

Nicotinamide Riboside Activates Mitochondrial Stress Response to Protect Against Osteoarthritis: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) is a protective system that helps mitochondria—the cell’s energy centers—function properly when damaged or stressed. Healthy mitochondr...

Nicotinamide Riboside Improves Fat Metabolism in High-Fructose-Fed Mice: Preclinical Findings

Synopsis High fructose intake can disrupt fat metabolism by causing resistance to a hormone called FGF21. In a preclinical study, mice given nicotinamide riboside (NR) alongside a high-fructose di...

Porcine Placental Extract Increases NAD+ and Energy in Human Skin Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is an important molecule that helps our cells produce energy. As we age, NAD+ levels naturally decrease in many tissues, which can contribute to a...

Nicotinamide Riboside and Metabolic Cofactors Improve Gut Health in Fatty Liver Disease: Preclinical Findings

SynopsisThe gut barrier controls what passes into the body and protects organs like the liver. An unhealthy diet and lifestyle cause gut microbiome imbalances (dysbiosis) and gut barrier damage, wh...

Tracking Nicotinamide Riboside Uptake in Cancer Cells: Preclinical Findings

Synopsis Researchers developed a bioluminescent probe (BiNR) to visualize how nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—is taken up by cells and tissues in real time. This tool ...

Intravenous Nicotinamide Riboside Protects the Heart from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Doxorubicin, a widely used chemotherapy drug, is effective against many cancers but often causes dose-dependent heart damage, leading to chronic heart failure. This study evaluated the ca...