Changes in NMN/NAD+ Ratio Activates SARM1 to Trigger Nerve Damage: Preclinical Findings

SynopsisAxon degeneration is a key feature of many neurodegenerative diseases. SARM1 is an enzyme that breaks down NAD+ and, when activated, causes axon destruction. The enzyme NMNAT2 normally conv...

Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Objectives To investigate the effects of NAD-boosting therapy via NR on Fndc5/irisin levels in humans and its potential role in the development and progression of nonalcoholic fatty liver disease ...

Nanocrystal Nicotinamide Riboside Improves Absorption and Protects the Heart: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative that boosts NAD+ to support mitochondrial energy, often loses effectiveness when taken orally because it breaks down too quickly in the...

Nicotinamide Riboside Improves Muscle Quality and Cellular Energy: Preclinical Findings

SynopsisNAD+, crucial for mitochondrial energy production, declines with age, potentially reducing physical performance. This study tested short-term NR supplementation in middle-aged mice and its ...

The Effects of NAD+ Boosting on Cold-Stimulated Brown Adipose Tissue Activity: Clinical Findings

Objectives To investigate whether NR stimulates brown adipose tissue in humans. Journal The Journal of Clinical Endocrinology & Metabolism Key Outcomes NR supplementation had no effect on col...

Equilibrative Nucleoside Transporters Transport Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3, is known to boost levels of NAD+, a vital molecule for energy production and cellular repair. However, how NR gets into cells has remaine...

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...

Counteracting CD38-Induced NAD+ Depletion Reduces Multiple Organ Fibrosis: Preclinical Findings

SynopsisSystemic sclerosis (SSc) involves fibrosis in multiple organs, but its cause is not fully understood. NAD+ decline with age and disease, often due to increased CD38 activity (an NADase), ma...

Treatment with S-Adenosylmethionine and Nicotinamide Riboside Immune Function in Arts Syndrome: Case Report

Objectives To assess whether co-therapy with S-adenosylmethionine (SAMe) and NR could improve clinical symptoms, immune cell function, and overall well-being in a child with Arts syndrome, beyond ...

Increasing NAD+ Improves Mitochondrial Function and Reduces Age-Related Amyloidosis: Preclinical Findings

Synopsis As we age, our muscles lose their ability to maintain proper protein balance and mitochondrial health, leading to weakness and degeneration. This study found that aging causes amyloid-lik...

NAD+ Metabolism and Its Roles in Cellular Processes During Aging: Review

SynopsisNAD+ is crucial for energy production and for enzymes that control DNA repair, gene activity, aging, and immune function. As we age, NAD+ levels drop in many tissues, and this decline is li...

Nicotinamide Riboside Protects the Liver from Alcohol-Induced Damage: Preclinical Findings

Synopsis Alcoholic liver disease (ALD) is a major consequence of long-term alcohol use, yet safe and effective treatments are still limited. This study found that nicotinamide riboside (NR), a vit...

Nicotinamide Riboside Enhances Muscle Growth and Fiber Density in Chicken Embryos: Preclinical Findings

Synopsis Researchers injected nicotinamide riboside (NR) into fertilized chicken eggs to study its effects on muscle growth. NR increased the weight, length, and width of the pectoral muscles in c...

Nicotinamide Riboside Protects Lens Cells from Oxidative Stress: Preclinical Findings

Synopsis Researchers found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, can protect eye lens cells from oxidative stress, one of the main causes of cataracts. In la...

Nicotinamide Riboside Supplementation Enhances NAD+ Metabolism in Ataxia Telangiectasia: Clinical Findings

Objectives To study the metabolic effects of treatment with NR in a cohort of patients with ataxia-telangiectasia (AT). Journal Metabolites Key Outcomes NR-related pathways and metabolites signi...

Nicotinamide Riboside and Pterostilbene Protect Motor Neurons in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the gradual loss of motor neurons, largely due to oxidative stress and inflammation. In both human trials an...

Cockayne Syndrome Proteins Maintain Mitochondrial Health Through NAD+ Signaling: Preclinical Findings

SynopsisCockayne syndrome (CS) is a rare premature aging disorder involving DNA repair defects and mitochondrial dysfunction. Across human, mouse, and nematode models, mitochondrial dysfunction was...

Nicotinamide Riboside Protects Against Acute Kidney Injury but Not Chronic Kidney Disease: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for kidney function, but its production is impaired in acute kidney injury (AKI) and chronic kidney disease (CKD). In human kidney bi...

Effects of Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes progressive muscle wasting due to loss of dystrophin. In dystrophin-deficient mice, muscles show depletion of NAD, an important metabolic cofactor...

CD38 Deletion and Nicotinamide Riboside Supplementation Slow Axon Degeneration After Facial Nerve Injury: Preclinical Findings

Synopsis After facial nerve injury (axotomy), nerve function often does not fully recover due to axon degeneration, neuron death, and ongoing inflammation. CD38, an enzyme that breaks down NAD+, m...