Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

SynopsisPoly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial...

Unique Mutations in Mouse Hepatitis Virus Reduce Virus Replication: Preclinical Findings

SynopsisAll coronaviruses contain a small domain called the macrodomain, or Mac1, within the nonstructural protein 3 (nsp3). Mac1 binds to and removes a molecule called mono-ADP-ribose (MAR) that a...

Nicotinamide Riboside Supplementation Combined with Other Nutrients Accelerates Recovery in COVID-19 Patients: Clinical Findings

Objectives To investigate supplementation of the combined metabolic activators (CMA), consisting of L-serine, N-acetyl-L-cysteine (NAC), NR, and L-carnitine tartrate for the treatment of patients ...

Nicotinamide Riboside Mitigates Cancer Cachexia: Preclinical Findings

Synopsis Cancer cachexia, a severe condition seen in advanced cancer patients, causes muscle loss, weight loss, and fat breakdown, greatly reducing quality of life and survival. This study found t...

Nicotinamide Riboside Treatment Protects Retinal Cells in Mice: Preclinical Findings

SynopsisGlaucoma often involves death of retinal ganglion cells (RGCs), partly caused by high eye pressure (IOP). But even when IOP is controlled, the disease can still worsen. So, it's important t...

Synthesis and Stability of Dihydronicotinamide Riboside from Nicotinamide Riboside Chloride: Preclinical Findings

SynopsisNRH, a highly effective synthetic NAD+ precursor, was produced in high yield from nicotinamide riboside chloride (NRCl) using a water-based reduction process under low-oxygen conditions. Th...

Nicotinamide Riboside-Supplemented Diet Delays Muscle Degeneration in Mice Lacking the NAMPT Gene: Preclinical Findings

SynopsisNAD+ helps enzymes keep energy balanced in cells, and the enzyme NAMPT controls how NAD+ is made. NAD+ is important for healthy muscle, but how it affects muscle growth isn't fully clear. T...

Nicotinamide Riboside Restores NAD+ and Autophagy After Kidney Injury: Preclinical Findings

Synopsis Acute kidney injury (AKI) can quickly lead to kidney failure and increase the risk of developing chronic kidney disease (CKD). In this study, scientists tested whether nicotinamide ribosi...

Nicotinamide Riboside Restores NAD+ and Mitochondrial Health in Polycystic Ovary Syndrome: Preclinical Findings

Synopsis Polycystic ovary syndrome (PCOS) is a common hormonal disorder that causes ovulation problems, infertility, and insulin resistance. Researchers found that women with PCOS have lower level...

Nicotinamide Riboside Improves Wound Healing in Diabetes: Preclinical Findings

Synopsis Poor wound healing is a common complication of diabetes, largely due to impaired blood vessel formation. This study found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+...

Nicotinamide Riboside Rejuvenates Aged Hematopoietic Stem Cells and Improves Regeneration: Preclinical Findings

SynopsisWith age, hematopoietic stem cells (HSCs) lose their ability to regenerate and remain quiescent, leading to an expanded stem cell pool that can cause blood disorders. Researchers found that...

Yeast-Mediated Nicotinamide Riboside Production in Craft Beers: Preclinical Findings

Synopsis Researchers measured nicotinamide riboside (NR), NAD+, and NMN levels in commercial and lab-scale beers. All beers contained NAD+, but NR and NMN were only found in beers made with certai...

Nicotinamide Riboside Restores Mitochondrial Function and Improves Heart Failure with Preserved Ejection Fraction: Preclinical Findings

SynopsisHeart Failure with Preserved Ejection Fraction (HFpEF) is a serious heart condition without effective treatments. In a mouse model of HFpEF, researchers found impaired mitochondrial fatty a...

Nicotinamide Riboside Protects Retinal Cells by Supporting Mitochondrial Health: Preclinical Findings

Synopsis Retinal degeneration diseases (RDDs), such as macular degeneration and retinitis pigmentosa, lead to the gradual loss of light-sensing cells in the eye, often caused by oxidative stress a...

Inhibiting CD38 and Boosting NAD+ with Nicotinamide Riboside Reduces Brain Inflammation: Preclinical Findings

SynopsisNeuroinflammation begins when the brain's innate immune system responds to inflammation. If not properly controlled, this inflammation worsens diseases like multiple sclerosis and Alzheimer...

Nicotinamide Riboside Reduces Alcohol-Induced Inflammation and Oxidative Stress in Immune Cells: Preclinical Findings

SynopsisMacrophages play an important role in inflammation and oxidative stress caused by alcohol. Researchers studied how nicotinamide riboside (NR), a precursor of NAD+, affects alcohol-induced i...

Nicotinamide Riboside Restores NAD+ and Prevents Age-Related Bone Loss: Preclinical Findings

SynopsisAge-related osteoporosis happens because of a decline in osteoblasts—the cells that build bone—and fewer osteoblast progenitor cells, which show signs of aging called senescence. FoxO trans...

17-α-Estradiol Extends Male Mouse Lifespan, While Nicotinamide Riboside Shows No Significant Effect: Preclinical Findings

SynopsisIn genetically diverse mice, the “non-feminizing” estrogen 17-α-estradiol (17aE2) increased median male lifespan by 19% when started at 16 months and by 11% when started at 20 months. It al...

Nicotinamide Riboside Improves Mitophagy and Reduces Neuroinflammation in Ataxia Telangiectasia: Preclinical Findings

SynopsisIn the premature aging disease ataxia telangiectasia (A-T), cells show mitochondrial dysfunction and a senescence state that causes inflammation (SASP). This is linked to buildup of damaged...

Nicotinamide Riboside Increased Liver Regeneration by Enhancing Mitochondrial Functions: Preclinical Findings

Synopsis The liver’s ability to regenerate after injury or surgery is vital for survival, but the metabolic mechanisms behind this process are not fully understood. This study found that losing th...