Nicotinamide Riboside Restores Mitochondrial Balance and Protects the Diabetic Heart: Preclinical Findings

Synopsis In diabetes, heart damage often occurs because of mitochondrial imbalance, where the cell’s energy-producing structures become fragmented and dysfunctional. This study found that nicotina...

DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

SynopsisDNA replication stress occurs when cells struggle to copy damaged DNA, affecting metabolism. Using mice lacking the DNA polymerase Rev1, researchers observed sex-specific metabolic changes:...

Nicotinamide Riboside Supplementation Benefits in Early Parkinson's Disease: Clinical Findings

Objectives To assess the safety, tolerability, and cerebral penetration of NR therapy in Parkinson's disease (PD) patients, as well as determine if NR has an impact on their neurometabolic profile...

Dihydronicotinamide Riboside Promotes a Pro-Inflammatory Macrophage Phenotype: Preclinical Findings

Synopsis This study explored how various NAD precursors—including nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), nicotinamide (NAM), and a newer compound called NRH—influence the b...

Increasing NAD+ with NR Protects Against Aortic Aneurysms: Preclinical Findings

Synopsis Researchers found that weakened mitochondrial function in blood vessel walls contributes to aortic aneurysms and ruptures, which can cause sudden death. In mice prone to atherosclerosis a...

Selective Mitochondrial Inheritance Links Metabolism to Cell Fate: Preclinical Findings

Synopsis This study discovered that the age of mitochondria—the cell’s energy-producing structures—plays a major role in determining how stem cells divide and develop. In epithelial stem-like cell...

NR and NMN Restore Meibomian Gland Function and Tear Health: Preclinical Findings

Synopsis This study found that increasing NAD+ levels in the eye can help reverse age-related meibomian gland dysfunction, a major cause of dry eye disease in older adults. The meibomian glands, l...

Effects of Intravenous Nicotinamide Riboside on Muscle NAD+: Preclinical Findings

Synopsis Although nicotinamide riboside (NR)—a common NAD+ booster—is believed to enhance energy metabolism, clinical studies have shown little effect on muscle function or insulin sensitivity. To...

Nicotinamide Riboside Reduces Chemotherapy-Induced Eye and Body Hypersensitivity: Preclinical Findings

SynopsisChemotherapy often causes dry eye and nerve pain, which may be due to nerve damage. This study treated rats given the chemotherapy drug paclitaxel with nicotinamide riboside (NR). Paclitaxe...

Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings

SynopsisThe gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice...

Nicotinamide Riboside Supplementation Boosts NAD+ and Lowers Inflammatory Immune Signaling in Lupus: Clinical Findings

Objectives To explore the anti-inflammatory effects of NR in monocytes (a type of white blood cell; immune cell) extracted from young, healthy subjects following supplementation. Additionally, the...

Nicotinamide Riboside Suppresses Coronavirus Replication: Preclinical Findings

Synopsis Viruses like SARS-CoV-2, which causes COVID-19, rely on the host’s metabolism to reproduce. This study used a related coronavirus model in mice to explore how metabolic interventions coul...

Nicotinamide Riboside Restores Heart Energy and Function in Heart Failure: Preclinical Findings

Synopsis More than half of people with heart failure have a condition called heart failure with preserved ejection fraction (HFpEF), but its causes are not well understood and current treatments a...

Nicotinamide Riboside Has Minor Metabolic Benefits in Obesity: Preclinical Findings

SynopsisNicotinamide riboside supplements (NRS) are thought to boost NAD+ levels and mitochondrial function, potentially improving muscle health and energy use. This study tested NRS effects in nor...

Genetically Encoded Sensors Measure NAD+/NADH Levels in Cell and Mitochondria Compartments: Preclinical Findings

SynopsisThe balance between oxidized (NAD+) and reduced (NADH) forms of NAD inside cells controls energy and antioxidant status. This ratio differs between mitochondria and cytosol and is important...

Nicotinamide Riboside Increases NAD+ Through Two Distinct Pathways: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, can increase NAD+ levels in the body through two mechanisms. When taken orally, NR is first directly absorbed and converted to NAD+ via th...

Rare SARM1 Variants Linked to ALS and Motor Nerve Disorders: Preclinical Findings

SynopsisSARM1 is a protein that breaks down NAD+, playing a key role in axon degeneration. Researchers found seven rare SARM1 gene variants in patients with ALS or other motor nerve disorders. Thes...

EPB41L4A-AS1 and Nicotinamide Riboside Support Brain Energy and Slow Aging: Preclinical FIndings

Synopsis The long non-coding RNA EPB41L4A-AS1 helps regulate NAD+ and ATP production in the brain, which are critical for energy and cellular function. In aging and Alzheimer's disease, EPB41L4A-A...

Mitophagy Enhancers, Including Nicotinamide Riboside, Protect Neurons from Tau-Induced Damage in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease (AD), abnormal tau proteins damage mitochondria and synapses, leading to impaired energy production and neuron loss. In mouse hippocampal neurons expressing mutant ...

Nicotinamide Riboside Prevents Liver Injury and Restores Mitochondrial Function: Preclinical Findings

SynopsisNAMPT is an enzyme that helps make NAD+. Since low liver NAD+ is linked to fatty liver disease, scientists removed NAMPT specifically from liver cells in mice to see the effect. These mice ...