Genetically Encoded Sensors Measure NAD+/NADH Levels in Cell and Mitochondria Compartments: Preclinical Findings

SynopsisThe balance between oxidized (NAD+) and reduced (NADH) forms of NAD inside cells controls energy and antioxidant status. This ratio differs between mitochondria and cytosol and is important...

Nicotinamide Riboside Increases NAD+ Through Two Distinct Pathways: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, can increase NAD+ levels in the body through two mechanisms. When taken orally, NR is first directly absorbed and converted to NAD+ via th...

Rare SARM1 Variants Linked to ALS and Motor Nerve Disorders: Preclinical Findings

SynopsisSARM1 is a protein that breaks down NAD+, playing a key role in axon degeneration. Researchers found seven rare SARM1 gene variants in patients with ALS or other motor nerve disorders. Thes...

EPB41L4A-AS1 and Nicotinamide Riboside Support Brain Energy and Slow Aging: Preclinical FIndings

Synopsis The long non-coding RNA EPB41L4A-AS1 helps regulate NAD+ and ATP production in the brain, which are critical for energy and cellular function. In aging and Alzheimer's disease, EPB41L4A-A...

Mitophagy Enhancers, Including Nicotinamide Riboside, Protect Neurons from Tau-Induced Damage in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease (AD), abnormal tau proteins damage mitochondria and synapses, leading to impaired energy production and neuron loss. In mouse hippocampal neurons expressing mutant ...

Nicotinamide Riboside Prevents Liver Injury and Restores Mitochondrial Function: Preclinical Findings

SynopsisNAMPT is an enzyme that helps make NAD+. Since low liver NAD+ is linked to fatty liver disease, scientists removed NAMPT specifically from liver cells in mice to see the effect. These mice ...

Combined Metabolic Activators Reduce Liver Fat by Boosting Mitochondria: Preclinical Findings

SynopsisWith NAFLD increasing globally and no approved treatments, researchers tested a combination of metabolic activators (including NAD+ precursor nicotinamide riboside, antioxidants, and amino ...

Metabolic Cofactors Including Nicotinamide Riboside Improves Non-Alcoholic Fatty Liver Disease: Preclinical Findings

SynopsisNon-alcoholic fatty liver disease (NAFLD) is a common liver condition linked to obesity and metabolic problems, but no effective treatment exists. Researchers tested a combination of metabo...

Nicotinamide Riboside and Metformin Restore Mitochondrial Function: Preclinical Findings

SynopsisMitophagy is the process cells use to clear damaged mitochondria, keeping cells healthy. Defects in this process are linked to neurodegenerative diseases. Using stem cell–derived brain cell...

Nicotinamide Riboside Improves Blood Cell Formation in Aging and Ataxia Telangiectasia: Preclinical Findings

SynopsisNAD+ supplements can boost mitochondrial health and DNA repair, which benefits stem cells in aging or disease. This study tested nicotinamide riboside (NR) in mice with reduced blood stem c...

In Ovo Feeding of Commercial Broiler Eggs: Preclinical Findings

SynopsisScientists have focused on improving muscle growth during early development because the number of muscle fibers formed before birth sets future growth potential. In poultry, feeding embryos...

Nicotinamide Riboside Protects Against Cardiac Hypertrophy by Reducing Inflammation and Oxidative Stress: Preclinical Findings

Synopsis Cardiac hypertrophy, a thickening of the heart muscle caused by pressure overload, can lead to heart failure. In mice, nicotinamide riboside (NR), a precursor to NAD+, reduced heart and l...

Nicotinamide Riboside Supplementation Improves Neurological Scores and Markers of Immune Health in Ataxia Telangiectasia: Clinical Findings

Objectives To investigate the effects of NR supplementation in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes NR supplementation improved ataxia scores (SARA an...

Nicotinamide Riboside Reduces Brain Inflammation, Protects Muscle Health, and Enhances Weight Loss in Obesity: Preclinical Findings

Synopsis Obesity treatments like calorie restriction (CR) often cause muscle loss and increase brain inflammation, which can interfere with weight control. In this study, obese rats were given CR,...

NAD+ Precursors in Health, Disease, and Aging: Review

SynopsisNAD+ is an essential molecule that helps the body make energy, send signals between cells, keep mitochondria healthy, and decide whether cells survive or die. Research shows that NAD+ level...

Mitophagy Enhancers, Including Nicotinamide Riboside, Are Protective in Alzheimer's Disease: Preclinical Findings

Synopsis This study examines whether mitophagy enhancers can protect brain cells from the harmful effects of mutant APP and amyloid beta (Aβ) in Alzheimer’s disease (AD). Since mitochondrial dysfu...

Nicotinamide Riboside Has Minor Effect on Energy Metabolism in Obesity: Preclinical Findings

SynopsisNR has been shown to reverse obesity-related health issues in mice, but effects may vary by strain. Researchers compared mildly obese C57BL/6N and C57BL/6J mice on high-fat diets, with or w...

Nicotinamide Riboside Reduces Brain Inflammation and Cellular Aging in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease, brain cells often show low NAD+ levels, high inflammation, and impaired cellular cleanup of damaged components. In mice with Alzheimer’s-like brain changes, five m...

Nicotinamide Riboside Reduces Heart Damage in Presence of Fentanyl, Midazolam, and Cangrelor: Preclinical Findings

SynopsisWhen blood flow to the heart is blocked and then restored—a process called ischemia-reperfusion injury—cells can be severely damaged. Researchers tested several potential protective compoun...

Disrupted NAD+ Metabolism Leads to Brain Defects in Zika Virus-Linked Microcephaly: Preclinical Findings

Synopsis Zika virus (ZIKV) infection during pregnancy can cause microcephaly, a condition where babies are born with abnormally small brains. In this study, researchers analyzed infected mouse bra...