Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...

Counteracting CD38-Induced NAD+ Depletion Reduces Multiple Organ Fibrosis: Preclinical Findings

SynopsisSystemic sclerosis (SSc) involves fibrosis in multiple organs, but its cause is not fully understood. NAD+ decline with age and disease, often due to increased CD38 activity (an NADase), ma...

Treatment with S-Adenosylmethionine and Nicotinamide Riboside Immune Function in Arts Syndrome: Case Report

Objectives To assess whether co-therapy with S-adenosylmethionine (SAMe) and NR could improve clinical symptoms, immune cell function, and overall well-being in a child with Arts syndrome, beyond ...

Increasing NAD+ Improves Mitochondrial Function and Reduces Age-Related Amyloidosis: Preclinical Findings

Synopsis As we age, our muscles lose their ability to maintain proper protein balance and mitochondrial health, leading to weakness and degeneration. This study found that aging causes amyloid-lik...

NAD+ Metabolism and Its Roles in Cellular Processes During Aging: Review

SynopsisNAD+ is crucial for energy production and for enzymes that control DNA repair, gene activity, aging, and immune function. As we age, NAD+ levels drop in many tissues, and this decline is li...

Nicotinamide Riboside Protects the Liver from Alcohol-Induced Damage: Preclinical Findings

Synopsis Alcoholic liver disease (ALD) is a major consequence of long-term alcohol use, yet safe and effective treatments are still limited. This study found that nicotinamide riboside (NR), a vit...

Nicotinamide Riboside Enhances Muscle Growth and Fiber Density in Chicken Embryos: Preclinical Findings

Synopsis Researchers injected nicotinamide riboside (NR) into fertilized chicken eggs to study its effects on muscle growth. NR increased the weight, length, and width of the pectoral muscles in c...

Nicotinamide Riboside Protects Lens Cells from Oxidative Stress: Preclinical Findings

Synopsis Researchers found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, can protect eye lens cells from oxidative stress, one of the main causes of cataracts. In la...

Nicotinamide Riboside Supplementation Enhances NAD+ Metabolism in Ataxia Telangiectasia: Clinical Findings

Objectives To study the metabolic effects of treatment with NR in a cohort of patients with ataxia-telangiectasia (AT). Journal Metabolites Key Outcomes NR-related pathways and metabolites signi...

Nicotinamide Riboside and Pterostilbene Protect Motor Neurons in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the gradual loss of motor neurons, largely due to oxidative stress and inflammation. In both human trials an...

Cockayne Syndrome Proteins Maintain Mitochondrial Health Through NAD+ Signaling: Preclinical Findings

SynopsisCockayne syndrome (CS) is a rare premature aging disorder involving DNA repair defects and mitochondrial dysfunction. Across human, mouse, and nematode models, mitochondrial dysfunction was...

Nicotinamide Riboside Protects Against Acute Kidney Injury but Not Chronic Kidney Disease: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for kidney function, but its production is impaired in acute kidney injury (AKI) and chronic kidney disease (CKD). In human kidney bi...

Effects of Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes progressive muscle wasting due to loss of dystrophin. In dystrophin-deficient mice, muscles show depletion of NAD, an important metabolic cofactor...

CD38 Deletion and Nicotinamide Riboside Supplementation Slow Axon Degeneration After Facial Nerve Injury: Preclinical Findings

Synopsis After facial nerve injury (axotomy), nerve function often does not fully recover due to axon degeneration, neuron death, and ongoing inflammation. CD38, an enzyme that breaks down NAD+, m...

Nicotinamide Riboside Lowers Cardiometabolic Risk Factors and Cardiac Oxidative Stress: Preclinical Findings

Synopsis Nicotinamide riboside (NR), known to boost NAD levels, was tested alone and combined with calorie restriction (CR) to evaluate effects on obesity and heart health in rats fed a high-calor...

Coronavirus Disrupts NAD+ Metabolism, While Nicotinamide Riboside Decreases Viral Replication: Preclinical Findings

Synopsis Certain enzymes called PARPs, which use NAD+ to modify proteins, play a role in the body’s defense against coronaviruses. Researchers found that SARS-CoV-2 infection increases the levels ...

NAD+ Precursors Improve Corneal Wound Healing and Nerve Regeneration in Diabetes: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is a vital molecule that supports energy metabolism, cell repair, and tissue regeneration. In diabetes, chronically high blood sugar disrupts thes...

Adult Zebrafish Provide an In Vivo Platform for Evaluating Drug Responses in Ethanol-Induced Acute Hepatic Injury: Preclinical FIndings

Synopsis Chronic alcohol use can damage the liver, but effective treatments are limited. Researchers developed an adult zebrafish model to quickly test drugs for alcohol-induced liver injury. Expo...

Nicotinamide Riboside Restores T-Cell Function in Tumors by Improving Mitochondrial Health: Preclinical Findings

Synopsis T cells that infiltrate tumors often become exhausted and lose their ability to fight cancer due to poor mitochondrial function and reduced mitophagy. This exhaustion involves lasting cha...

Nicotinamide Riboside Reduces Chemotherapy-Induced Peripheral Neuropathy and Suppresses Tumor Growth: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin B3 precursor of NAD+ that blunts diabetic and chemotherapy-induced peripheral neuropathy in preclinical models. This study tested whether NR also r...