Nicotinamide Riboside Protects the Liver from Alcohol-Induced Damage: Preclinical Findings

Synopsis

Alcoholic liver disease (ALD) is a major consequence of long-term alcohol use, yet safe and effective treatments are still limited. This study found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ booster, helps protect the liver from alcohol-induced damage by improving lipid metabolism and restoring balance in the gut microbiome–bile acid axis. In alcohol-exposed mice, NR increased the NAD+/NADH ratio, reduced fat buildup and bile acid accumulation in the liver, and improved liver structure and function. It also normalized the composition of gut bacteria and restored healthy bile acid profiles by lowering harmful acids and increasing beneficial ones. These results suggest that NR supplementation supports liver health by reducing oxidative stress, balancing gut bacteria, and improving fat metabolism, offering a promising strategy for preventing or treating alcoholic liver disease.

Journal

Food Science & Nutrition