Article: Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Clinical Liver Health

Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Objectives

To investigate the effects of NAD-boosting therapy via NR on Fndc5/irisin levels in humans and its potential role in the development and progression of nonalcoholic fatty liver disease (NAFLD).

Journal

Theranostics

Key Outcomes

NR supplementation increased plasma levels of Fndc5/irisin. A similar increase in plasma Fndc5/irisin was observed after two weeks of exercise, suggesting Fndc5/irisin may be a link between NAD+ and physical exercise.

Duration

2 weeks

Dose

1000 mg

Study Design

General screening test in 6 healthy subjects

See Published Study

Clinical

The Effects of NAD+ Boosting on Cold-Stimulated Brown Adipose Tissue Activity: Clinical Findings

Objectives To investigate whether NR stimulates brown adipose tissue in humans. Journal The Journal of Clinical Endocrinology & Metabolism Key Outcomes NR supplementation had no effect on cold...