Article: Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Feb 25, 2021 Clinical Liver Health

Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Objectives

To investigate the effects of NAD-boosting therapy via NR on Fndc5/irisin levels in humans and its potential role in the development and progression of nonalcoholic fatty liver disease (NAFLD).

Journal

Theranostics

Key Outcomes

NR supplementation increased plasma levels of Fndc5/irisin. A similar increase in plasma Fndc5/irisin was observed after two weeks of exercise, suggesting Fndc5/irisin may be a link between NAD+ and physical exercise.

Duration

2 weeks

Dose

1000 mg

Study Design

General screening test in 6 healthy subjects

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