Increasing NAD+ Improves Mitochondrial Function and Reduces Age-Related Amyloidosis: Preclinical Findings

Synopsis

As we age, our muscles lose their ability to maintain proper protein balance and mitochondrial health, leading to weakness and degeneration. This study found that aging causes amyloid-like protein buildup and mitochondrial dysfunction in muscle cells of worms, mice, and humans, similar to changes seen in inclusion body myositis, a muscle-wasting disease. Researchers discovered that maintaining NAD+, a molecule essential for cellular energy and repair, is key to preventing these problems. Treatment with nicotinamide riboside (NR)—a vitamin B3 derivative—and olaparib (AZD) boosted mitochondrial function, restored muscle balance, and reduced toxic amyloid deposits in aged animals and cells. These findings suggest that enhancing NAD+ metabolism may help preserve muscle strength and delay age-related muscle decline, supporting further research into NAD+-boosting therapies for aging muscles.

Journal

Cell Reports