NAD+ Metabolism and Its Roles in Cellular Processes During Aging: Review

Synopsis

NAD+ is crucial for energy production and for enzymes that control DNA repair, gene activity, aging, and immune function. As we age, NAD+ levels drop in many tissues, and this decline is linked to diseases such as cognitive impairment, cancer, muscle loss, and frailty. Restoring NAD+ levels can slow or even reverse some of these conditions in animal studies, making it a promising target for therapies to extend healthy lifespan. However, scientists still need to fully understand how NAD+ works in humans, the safest and most effective ways to boost it, and whether these benefits will translate to people.

JOURNAL

Nature Reviews Molecular Cell Biology