NAD+ Augmentation as a Disease-Modifying Strategy for Neurodegeneration: Review

SynopsisNeurodegenerative diseases are a growing global health problem with no current treatments that slow or stop their progression. Boosting nicotinamide adenine dinucleotide (NAD+) has emerged ...

Nicotinamide Riboside and Necroptosis Inhibition Improve ALS: Preclinical Findings

Synopsis TBK1 loss-of-function mutations linked to amyotrophic lateral sclerosis (ALS) were modeled in zebrafish using CRISPR and morpholino knockdown. Both approaches caused early motor deficits,...

Combination Therapy with Nicotinamide Riboside, Pterostilbene, and Ibudilast Protects Motor Neurons and Prolongs Survival in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by oxidative stress, inflammation, and the progressive death of motor neurons. This study tested a triple t...

Effect of the Mediterranean Diet Supplemented with Nicotinamide Riboside, Pterostilbene, and/or Coconut Oil in ALS Patients: Pilot Clinical Findings

Objectives To assess the effects of a Mediterranean diet supplemented with nicotinamide riboside (NR) and pterostilbene, with or without coconut oil, on body weight, composition, BMI, and overall ...

Nicotinamide Riboside and Pterostilbene Therapy Improves Cell Metabolism and Shows Promise in ALS: Preclinical Findings

Synopsis Researchers studying amyotrophic lateral sclerosis (ALS) found that not all patients share the same metabolic profile, meaning their cells process energy differently. In particular, one s...

Rare SARM1 Variants Linked to ALS and Motor Nerve Disorders: Preclinical Findings

SynopsisSARM1 is a protein that breaks down NAD+, playing a key role in axon degeneration. Researchers found seven rare SARM1 gene variants in patients with ALS or other motor nerve disorders. Thes...

Nicotinamide Riboside and Pterostilbene Protect Motor Neurons in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the gradual loss of motor neurons, largely due to oxidative stress and inflammation. In both human trials an...

Nicotinamide Riboside Increases NAD+ and Protects Neurons in ALS Models: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively die. Astrocytes from ALS models can cause motor neuron death in cell cultures. Boosting NAD+ levels or i...

Nicotinamide Riboside Supports Mitochondrial Health and Neurogenesis in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively degenerate, leading to muscle weakness and paralysis. Declines in NAD+ contribute to mitochondrial dysfu...

Nicotinamide Riboside Protects Motor Neurons in ALS: Preclinical Findings

Synopsis Sirtuins (SIRTs) are enzymes that rely on NAD+ and help regulate DNA repair, metabolism, and oxidative stress. Boosting NAD+ levels can activate SIRTs and antioxidant proteins, reducing m...

Nicotinamide Riboside and Pterostilbene Slow Disease Progression in ALS Patients: Clinical Findings

Objectives To assess the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation in people with amyotrophic lateral sclerosis (ALS). Journal Amyotrophi...

Nicotinamide Riboside Provides Benefit in Amyotrophic Lateral Sclerosis: Preclinical Findings

Synopsis This study explores how boosting nicotinamide adenine dinucleotide (NAD+) metabolism in astrocytes can protect neurons from degeneration in amyotrophic lateral sclerosis (ALS). NAD+ is vi...