Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

Standardized Assay Quantifies NAD+ and NADH in Worms, Mice, and Human Blood: Preclinical Findings

SynopsisA standardized assay was developed to measure NAD+, NADH, and the NAD+/NADH ratio across multiple biological samples, including C. elegans, mouse muscle, mouse blood, and human blood. The p...

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

Nicotinamide Riboside Restores NAD+ and Improves Survival of Neurons with Autophagy Defects: Preclinical Findings

SynopsisAutophagy is a cellular recycling process vital for neuron survival, and its failure contributes to neurodegenerative diseases. This study generated human neurons lacking the autophagy gene...

Autophagy Promotes Cell Survival by Maintaining Stable NAD+ Levels: Preclinical Findings

SynopsisAutophagy is a cellular process that removes damaged parts of the cell and is important for healthy aging. When autophagy is lost, NAD+ levels fall due to increased activity of enzymes that...

NAD+ Precursors: A Questionable Redundancy: Review

SynopsisIn the last decade, there's been growing interest in treating metabolic and age-related diseases by boosting NAD+ levels in cells. The most common approach is taking NAD+ precursors, a grou...

Therapeutic Potential of NAD-Boosting Molecules: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is best known as a hydrogen carrier in energy-producing reactions, but it also acts as a signaling molecule that controls hundreds of vital processe...

The Biology and Therapeutic Potential of Nicotinamide Riboside and Nicotinamide Mononucleotide: Review

SynopsisResearch on NAD+ biology has surged, especially around two intermediates—nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—which show promise in preventing and treating age-r...

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

SynopsisFirst discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory protein...

NAD+ Metabolism in Health and Disease: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is a molecule that helps enzymes in energy reactions and is also used by other enzymes involved in DNA repair, cell signaling, and regulating cell h...