Fixing Imbalanced NAD Metabolism Reduces Effects of Telomere Dysfunction: Preclinical Findings

Synopsis Short telomeres cause diseases like dyskeratosis congenita (DC), which lack effective treatments. This study found that cells from DC patients and telomerase-deficient mice have low NAD+ ...

Nicotinamide Riboside Protects Optic Nerve from Degeneration: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, protects optic nerve axons from damage caused by tumor necrosis factor (TNF). In rats, NR reduced axon loss, improved autophagy markers (i...

Nicotinamide Riboside and Pterostilbene Increase NAD+ Levels in Patients with Acute Kidney Injury: Clinical Findings

Objectives To evaluate the effects of escalating doses of nicotinamide riboside and pterostilbene (NRPT) on blood NAD+ levels and safety outcomes in patients hospitalized with acute kidney injury ...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effe...

A New Bioluminescent Probe to Monitor Mitochondrial Health Over Time: Preclinical Findings

SynopsisMitochondrial membrane potential (ΔΨm) is a key indicator of mitochondrial health and is involved in diseases like diabetes, cancer, Alzheimer’s, and Parkinson’s. This study introduces a ne...

Nicotinamide Riboside Protects Against Light-Induced Retinal Degeneration: Preclinical Findings

SynopsisRetinal diseases cause a decline in nicotinamide adenine dinucleotide (NAD+), a vital coenzyme for cellular energy and biosynthesis, which may contribute to retinal damage. This study teste...

Safety Evaluation of Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Oral Toxicity Study: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that boosts NAD+ levels and may help counter age-related declines in cellular energy. This study tested the safety of a high-purity, syn...

In Ovo Nicotinamide Riboside Injection Improves Broiler Chicken Muscle Growth: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR) affects the development and growth of the pectoralis major muscle (PM) in broiler chickens. Fertilized eggs were injected on day 10 of i...

SARM1 Drives Nerve Damage Following Inflammation and Cell Death Signals: Preclinical Findings

SynopsisNeuroinflammation and a type of cell death called necroptosis play big roles in neurodegenerative diseases, often starting with damage to nerve fibers called axons. SARM1 is a key enzyme th...

Nicotinamide Riboside Protects Against Obesity-Induced Atrial Fibrillation: Preclinical FIndings

Synopsis Aging and obesity increase the risk of atrial fibrillation (AF), a condition where the heart beats irregularly. Nicotinamide phosphoribosyltransferase (Nampt) produces NAD+, which is cruc...

Nicotinamide Riboside Improves Social Behavior and Anxiety in Autism: Preclinical Findings

Synopsis Oxytocin (OT) is essential for social recognition, memory, and emotional behaviors, and it also reduces anxiety, especially during stress. CD38 is an enzyme that produces cyclic ADP-ribos...

Nicotinamide Riboside Improves Ovarian Health and Fertility in Aging: Preclinical Findings

Synopsis As female mice age, their ovaries lose follicles and the quality of eggs declines, partly due to lower levels of NAD+. In this study, supplementing aging mice with nicotinamide riboside (...

Nicotinamide Riboside—Therapeutic Applications and Current State of Research: Review

SynopsisNicotinamide riboside (NR) is a form of vitamin B3 and a building block for NAD+, a coenzyme essential for energy production, DNA repair, and cell communication. NR has gained attention for...

Nicotinamide Mononucleotide Improves Blood Vessel Function by Converting to Nicotinamide Riboside: Preclinical Findings

Synopsis Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are compounds that help make NAD+, which may protect blood vessels. Researchers studied how NMN and NR affect inflammation...

Nicotinamide Riboside Reverses Age-Related Circadian and Mitochondrial Decline: Preclinical Findings

Synopsis Aging disrupts sleep patterns and circadian rhythms, which are linked to metabolic diseases and lower NAD+ levels. This study shows that supplementing with the NAD+ precursor nicotinamide...

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy h...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...

Nicotinamide Riboside Reduces Neuroinflammation in Gulf War Illness: Preclinical Findings

Synopsis Gulf War Illness (GWI) affects about 30% of 1991 Gulf War veterans, causing fatigue, pain, and cognitive issues linked to mitochondrial dysfunction. Researchers found that veterans with G...

Nicotinamide Riboside Partially Protects Neurons from TOP1-Linked Neurodegeneration and Extends Lifespan: Preclinical FIndings

Synopsis Topoisomerase 1 (TOP1) helps relieve DNA stress during gene transcription, especially for long genes critical to neuron function. Deleting TOP1 in mouse cortical and hippocampal neurons c...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...