Nicotinamide Riboside Reverses Age-Related Circadian and Mitochondrial Decline: Preclinical Findings

Synopsis Aging disrupts sleep patterns and circadian rhythms, which are linked to metabolic diseases and lower NAD+ levels. This study shows that supplementing with the NAD+ precursor nicotinamide...

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy h...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...

Nicotinamide Riboside Reduces Neuroinflammation in Gulf War Illness: Preclinical Findings

Synopsis Gulf War Illness (GWI) affects about 30% of 1991 Gulf War veterans, causing fatigue, pain, and cognitive issues linked to mitochondrial dysfunction. Researchers found that veterans with G...

Nicotinamide Riboside Partially Protects Neurons from TOP1-Linked Neurodegeneration and Extends Lifespan: Preclinical FIndings

Synopsis Topoisomerase 1 (TOP1) helps relieve DNA stress during gene transcription, especially for long genes critical to neuron function. Deleting TOP1 in mouse cortical and hippocampal neurons c...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Nicotinamide Riboside Protects Against Noise-Induced Hearing Loss: Preclinical Findings

Synopsis Noise exposure can damage hearing by reducing the number of ribbon synapses in the inner ear, which are crucial for transmitting sound signals. In mice, temporary noise exposure caused a ...

NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

Synopsis The heart’s electrical activity depends on sodium channels (NaV1.5) and dysfunction can cause dangerous arrhythmias. Researchers studied how NAD+ precursors nicotinamide riboside (NR) and...

Tracking NAD+ Metabolism in Real Time Using a Genetically Encoded Fluorescent Sensor: Preclinical Findings

Synopsis Tracking NAD+ metabolism in living cells and animals is challenging, but FiNad sensors make it possible. These fluorescent, genetically encoded sensors can detect changes in NAD+ levels i...

Gut Bacteria Support NAD+ Production: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for hundreds of cellular processes, including metabolism, DNA repair, and aging. How environmental factors affect NAD+ metabolism is ...

Nicotinamide Riboside Improves DNA Repair, Inflammation, and Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of fatty plaques in arteries, is a leading cause of heart disease. Beyond cholesterol and inflammation, new research shows that DNA damage in blood vessels al...

Activating the NRK Pathway Improves NAD+ Recycling in Muscle Disorders: Preclinical Findings

Synopsis Hexose-6-Phosphate Dehydrogenase (H6PD) produces NADPH inside the endoplasmic/sarcoplasmic reticulum (ER/SR), helping activate glucocorticoid hormones. However, its broader role in mainta...

Neonatal Nicotinamide Riboside and Resveratrol Epigenetically Program White Fat Browning: Preclinical Findings

Synopsis Giving newborn male mice resveratrol (RSV) or nicotinamide riboside (NR) can “program” their white fat to develop brown fat-like features (WAT browning) and improve metabolism later in li...

Nicotinamide Riboside Increases NAD+ and Protects Neurons in ALS Models: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively die. Astrocytes from ALS models can cause motor neuron death in cell cultures. Boosting NAD+ levels or i...

Nicotinamide Riboside Protects the Brain from Hypertension-Related Small Vessel Damage: Preclinical Findings

Synopsis Hypertension can cause damage to small blood vessels in the brain, leading to memory problems and white matter injury, but treatments are limited. In this study, mice with angiotensin-ind...

Nicotinamide Riboside Prevents Hearing Loss in Cockayne Syndrome: Preclinical Findings

Synopsis Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are curr...

Nicotinamide Riboside Supports Mitochondrial Health and Neurogenesis in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively degenerate, leading to muscle weakness and paralysis. Declines in NAD+ contribute to mitochondrial dysfu...

Increasing NAD+ with Nicotinamide Riboside Protects Neurons in Spinocerebellar Ataxia Type 7: Preclinical Findings

Synopsis Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder that damages the cerebellum and impairs movement. Researchers found that in SCA7 mice, key genes controlling calcium in cerebell...

Nicotinamide Riboside Protects Against Alcohol-Induced Depression via the Gut-Brain Axis: Preclinical Findings

Synopsis The gut microbiome influences brain health and mood, and nicotinamide riboside (NR) has shown neuroprotective effects. This study tested whether NR could prevent alcohol-induced depressio...