Article: Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Clinical Inflammation Muscle Health

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives

To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults.

Journal

The Journal of Physiology

Key Outcomes

NR supplementation did not alter NAD-sensitive signaling pathways in skeletal muscle and did not have any effect on skeletal muscle mitochondrial respiration nor whole-body metabolism.
Although NR did not increase skeletal muscle NAD+ levels, it increased markers of NAD flux, demonstrating the skeletal muscle bioavailability of NR supplementation.

Duration

1 week

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 8 young, healthy, recreationally active men

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