Inhibition of NAMPT and CD73 Suppresses Tumor Growth: Preclinical Findings

Synopsis Researchers are exploring new ways to treat ovarian cancer by targeting how tumor cells produce and recycle energy. This study focused on NAD+, a key molecule for cellular metabolism, and...

NAD+ in Aging, Metabolism, and Neurodegeneration: Review

SynopsisNAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage c...

Nicotinamide Riboside Reduces Inflammation and Supports Mitochondrial Health: Preclinical Findings

Synopsis Activation of the NLRP3 inflammasome, a key driver of inflammation linked to metabolic dysfunction, can be influenced by nutrient levels and mitochondrial health. In a study of healthy vo...

How NAD+ Recycling Pathways Influence Virulence in Pneumonia Bacteria: Preclinical Findings

SynopsisNAD is an essential molecule found in all living cells. Some bacteria, like Streptococcus pneumoniae, cannot make NAD from scratch and must recycle it by importing related compounds such as...

Nicotinamide Riboside Reduces Liver Inflammation in Diabetes: Preclinical Findings

Synopsis Chronic low-grade inflammation—known as metaflammation—is a key driver of conditions like type 2 diabetes, obesity, and cardiovascular disease. This study investigated whether nicotinamid...

Nicotinamide Riboside Partially Improves Heart Function in Iron-Deficient Conditions: Preclinical Findings

Synopsis Both too much and too little iron can damage the heart, but the way heart cells use iron is not fully understood. In this study, researchers investigated the role of the transferrin recep...

Nicotinamide Riboside and Nicotinic Acid Riboside Production in Human Cells: Preclnical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy metabolism and many cell signaling processes, but because it is constantly used and broken down, cells must continuously r...

Nicotinamide Riboside Improves Mitochondrial Function in Mutant Human Cells: Preclinical Findings

Synopsis Mitochondrial disorders are severe genetic conditions that disrupt energy production, and currently, no effective treatments exist. This study explored whether boosting NAD+, a vital mole...

Nicotinamide Riboside Mediates Longevity Benefits of Calorie Restriction: Preclinical Findings

Synopsis Calorie restriction (CR) is known to extend lifespan in yeast, but how this benefit is communicated between cells has remained unclear. In this study, researchers found that while CR does...

Increasing NAD+ with Nicotinamide Riboside Prevents Liver Cancer Driven by URI: Preclinical Findings

Synopsis The molecular causes of liver cancer (hepatocellular carcinoma, HCC) are not fully understood. This study used genetically modified mice to show that when liver cells produce too much of ...

Increasing NAD+ Production in Muscle Alone Does Not Improve Metabolism: Preclinical Findings

SynopsisNicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), precursors of NAD+, are known to help resist metabolic problems caused by high-fat diets partly by boosting oxidative metab...

A High-Fat Diet and Increasing NAD+ Rescues Premature Aging in Cockayne Syndrome: Preclinical Findings

Synopsis Cockayne syndrome (CS) is a rare genetic disorder that causes early aging and progressive brain degeneration due to problems in DNA repair genes (CSA or CSB). In mice with the CSB mutatio...

Human CD157 Enzyme Regulates NAD+ Precursors to Support Metabolism: Preclinical Findings

Synopsis Human CD157 (hCD157) is an enzyme that helps regulate cell metabolism and immune function and may be linked to neurodegenerative and metabolic diseases. Researchers found that hCD157 brea...

Nicotinamide Riboside Improved Endurance in Mitochondrial Disease: Preclinical Findings

Synopsis Mitochondrial disorders are rare but serious diseases caused by defects in the cell’s energy-producing machinery, known as the mitochondrial respiratory chain. These conditions often lead...

Mitochondrial Dysfunction Linked to NAD+ Decline and DNA Repair Dysfunction: Preclinical Findings

SynopsisMitochondrial problems are common in aging and neurodegenerative diseases. In xeroderma pigmentosum group A (XPA), a disease caused by faulty DNA repair that leads to severe neurodegenerati...

Nicotinamide Riboside Transporter Mediates AICAr Uptake in Yeast, But Not Human Cells: Preclinical Findings

Synopsis This study focuses on cellular metabolism and examines how cells take up and respond to a compound called AICAR, which mimics a low-energy state and can slow cell growth. AICAR must enter...

Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Synopsis NADases are enzymes that break down NAD+ into smaller molecules, but their exact role isn't clear. This study found a new NADase on the surface of rabbit red blood cell precursors. It is ...

Nicotinamide Riboside Delays Mitochondrial Myopathy Disease Progression: Preclinical Findings

Synopsis Mitochondrial diseases disrupt the body’s ability to produce energy, leading to muscle weakness and other serious health problems. Because these disorders impair the balance of key energy...

NR and NMN Influence NAD+ Metabolism to Improve Anti-Cancer Therapy: Preclinical Findings

Synopsis In human cells, NAD+ is mainly produced through “salvage” pathways that recycle precursors like nicotinamide, nicotinic acid, and nicotinamide riboside (NR). Blocking this process with th...

Nicotinamide Riboside Enhances Mitochondrial Function and Extends Lifespan: Preclinical Findings

Synopsis NAD+ is a vital molecule that maintains metabolic balance and fuels sirtuin enzymes, which help regulate aging and energy use. In this study, researchers found that NAD+ levels decline wi...