Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Synopsis NADases are enzymes that break down NAD+ into smaller molecules, but their exact role isn't clear. This study found a new NADase on the surface of rabbit red blood cell precursors. It is ...

Nicotinamide Riboside Delays Mitochondrial Myopathy Disease Progression: Preclinical Findings

Synopsis Mitochondrial diseases disrupt the body’s ability to produce energy, leading to muscle weakness and other serious health problems. Because these disorders impair the balance of key energy...

NR and NMN Influence NAD+ Metabolism to Improve Anti-Cancer Therapy: Preclinical Findings

Synopsis In human cells, NAD+ is mainly produced through “salvage” pathways that recycle precursors like nicotinamide, nicotinic acid, and nicotinamide riboside (NR). Blocking this process with th...

Nicotinamide Riboside Enhances Mitochondrial Function and Extends Lifespan: Preclinical Findings

Synopsis NAD+ is a vital molecule that maintains metabolic balance and fuels sirtuin enzymes, which help regulate aging and energy use. In this study, researchers found that NAD+ levels decline wi...

NAD+ Metabolism as a Therapeutic Target for Age-Related Metabolic Diseases: Review

SynopsisNAD+ is a central redox cofactor, but its role in activating sirtuins—a family of NAD-dependent proteins that optimize mitochondrial function—has made it a focus of longevity research. Beca...

Nicotinamide Riboside Improves Memory and Learning in Alzheimer's Disease: Preclinical Findings

Synopsis NAD+ is an important coenzyme that supports energy production in mitochondria and is linked to longevity and protection against Alzheimer’s disease (AD). Its precursor, nicotinamide ribos...

Nicotinamide Riboside Protects Against High-Fat Diet-Induced Obesity: Preclinical Findings

Synopsis NAD+ is a crucial molecule required for the activity of sirtuin enzymes, which regulate energy use and cellular health. Because of this, adjusting NAD+ levels has become an important way ...

Yeast Control NAD+ Levels by Regulating Nicotinamide Riboside and Nicotinic Acid Export: Preclinical Findings

Synopsis NAD+ serves as both a key coenzyme in metabolic reactions and a substrate for enzymes like sirtuins that regulate aging and stress responses. Its synthesis is essential for extending life...

Pathway for Mitochondrial NAD+ Production in Human Cells Revealed: Preclinical Findings

Synopsis NAD⁺ is an essential molecule for cellular energy and signaling, but how it is made and distributed inside human cells is not fully understood. In particular, the source of mitochondrial ...

Nicotinamide Riboside and Nicotinic Acid Riboside Metabolism in Fungi and Mammals: Preclinical Findings

Synopsis NAD+ is an important coenzyme that helps many cellular reactions and supports enzymes like sirtuins, which regulate aging and stress responses. In yeast, adding nicotinamide riboside (NR)...

Gene Identified That Encodes Nicotinamide Riboside Transporter: Preclinical Findings

Synopsis Nicotinamide riboside is a newly identified precursor of NAD+, a vital coenzyme involved in energy metabolism and sirtuin activity. Supplementing yeast with nicotinamide riboside extends ...

Structural Insights Into Nicotinamide Riboside Kinase Reveal How Cells Make NAD+: Preclinical Findings

Synopsis The nicotinamide riboside kinase (Nrk) pathway, active in eukaryotic cells, plays a vital role in converting nicotinamide riboside into nicotinamide adenine dinucleotide (NAD⁺), an essent...

SIRT1 Activators Like Nicotinamide Riboside Prevent Neuron Damage in Mouse Model of Multiple Sclerosis: Preclinical Findings

Synopsis Axonal damage and neuron loss contribute to permanent vision loss and neurological disability in optic neuritis and multiple sclerosis (MS). Current treatments mainly target inflammation ...

NAD+ Metabolism in Health and Disease: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is a molecule that helps enzymes in energy reactions and is also used by other enzymes involved in DNA repair, cell signaling, and regulating cell h...

Boosting NAD+ Production Protects Nerves and Slows Axon Degeneration After Injury: Preclinical Findings

Synopsis Axonal degeneration, a major cause of nerve damage in neurodegenerative diseases and after traumatic injury, is a self-destructive process separate from normal cell death. Previous studie...

Nicotinamide Riboside Boosts NAD+ and Extends Lifespan in Yeast: Preclinical Findings

Synopsis In yeast, NAD+ is essential for the activity of Sir2, a protein linked to longevity. Previous studies showed that changing NAD+ precursors could affect aging, but none extended lifespan. ...

Discovery of Nicotinamide Riboside as a Natural NAD+ Precursor in Humans and Yeast: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is a vital molecule required by all living organisms. It functions both as a coenzyme that supports energy-producing reactions and as a source of ...