Article: Nicotinamide Riboside Restores T-Cell Function in Tumors by Improving Mitochondrial Health: Preclinical Findings

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Cancer Immune Health Preclinical

Nicotinamide Riboside Restores T-Cell Function in Tumors by Improving Mitochondrial Health: Preclinical Findings

Synopsis

T cells that infiltrate tumors often become exhausted and lose their ability to fight cancer due to poor mitochondrial function and reduced mitophagy. This exhaustion involves lasting changes in their gene expression and epigenetic programming. In this study, supplementing with nicotinamide riboside (NR) improved mitochondrial fitness in tumor-infiltrating T cells, helping them regain function and respond better to anti-PD-1 cancer therapy. These findings show that NR can counteract tumor-induced T cell exhaustion by supporting mitochondrial health and metabolic function.

Journal

Nature Immunology

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Neurological Health

Nicotinamide Riboside Reduces Chemotherapy-Induced Peripheral Neuropathy and Suppresses Tumor Growth: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin B3 precursor of NAD+ that blunts diabetic and chemotherapy-induced peripheral neuropathy in preclinical models. This study tested whether NR also r...

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Liver Health

Adult Zebrafish Provide an In Vivo Platform for Evaluating Drug Responses in Ethanol-Induced Acute Hepatic Injury: Preclinical FIndings

Synopsis Chronic alcohol use can damage the liver, but effective treatments are limited. Researchers developed an adult zebrafish model to quickly test drugs for alcohol-induced liver injury. Expo...

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