The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Nicotinamide Riboside Protects Against Noise-Induced Hearing Loss: Preclinical Findings

Synopsis Noise exposure can damage hearing by reducing the number of ribbon synapses in the inner ear, which are crucial for transmitting sound signals. In mice, temporary noise exposure caused a ...

NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

Synopsis The heart’s electrical activity depends on sodium channels (NaV1.5) and dysfunction can cause dangerous arrhythmias. Researchers studied how NAD+ precursors nicotinamide riboside (NR) and...

Tracking NAD+ Metabolism in Real Time Using a Genetically Encoded Fluorescent Sensor: Preclinical Findings

Synopsis Tracking NAD+ metabolism in living cells and animals is challenging, but FiNad sensors make it possible. These fluorescent, genetically encoded sensors can detect changes in NAD+ levels i...

Gut Bacteria Support NAD+ Production: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for hundreds of cellular processes, including metabolism, DNA repair, and aging. How environmental factors affect NAD+ metabolism is ...

Nicotinamide Riboside Improves DNA Repair, Inflammation, and Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of fatty plaques in arteries, is a leading cause of heart disease. Beyond cholesterol and inflammation, new research shows that DNA damage in blood vessels al...

Activating the NRK Pathway Improves NAD+ Recycling in Muscle Disorders: Preclinical Findings

Synopsis Hexose-6-Phosphate Dehydrogenase (H6PD) produces NADPH inside the endoplasmic/sarcoplasmic reticulum (ER/SR), helping activate glucocorticoid hormones. However, its broader role in mainta...

Neonatal Nicotinamide Riboside and Resveratrol Epigenetically Program White Fat Browning: Preclinical Findings

Synopsis Giving newborn male mice resveratrol (RSV) or nicotinamide riboside (NR) can “program” their white fat to develop brown fat-like features (WAT browning) and improve metabolism later in li...

Nicotinamide Riboside Increases NAD+ and Protects Neurons in ALS Models: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively die. Astrocytes from ALS models can cause motor neuron death in cell cultures. Boosting NAD+ levels or i...

Nicotinamide Riboside Protects the Brain from Hypertension-Related Small Vessel Damage: Preclinical Findings

Synopsis Hypertension can cause damage to small blood vessels in the brain, leading to memory problems and white matter injury, but treatments are limited. In this study, mice with angiotensin-ind...

Nicotinamide Riboside Prevents Hearing Loss in Cockayne Syndrome: Preclinical Findings

Synopsis Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are curr...

Nicotinamide Riboside Supports Mitochondrial Health and Neurogenesis in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively degenerate, leading to muscle weakness and paralysis. Declines in NAD+ contribute to mitochondrial dysfu...

Increasing NAD+ with Nicotinamide Riboside Protects Neurons in Spinocerebellar Ataxia Type 7: Preclinical Findings

Synopsis Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder that damages the cerebellum and impairs movement. Researchers found that in SCA7 mice, key genes controlling calcium in cerebell...

Nicotinamide Riboside Protects Against Alcohol-Induced Depression via the Gut-Brain Axis: Preclinical Findings

Synopsis The gut microbiome influences brain health and mood, and nicotinamide riboside (NR) has shown neuroprotective effects. This study tested whether NR could prevent alcohol-induced depressio...

Extracellular NAD+ Broken Down by Human Cells to Maintain Intracellular NAD+ Levels: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and human cells replenish NAD+ by using extracellular precursors like nicotinamide (NAM), nicotinic ac...

Study of Nicotinamide Riboside's Properties and Degradation Kinetics: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 and a precursor to NAD+, shows promise as a therapeutic compound for aging. However, little is known about its physical and chemical prope...

Nicotinamide Riboside Administration Improves Mitophagy and Slows Aging in Werner Syndrome: Preclinical Findings

Synopsis Werner syndrome (WS) is a premature aging disease caused by mutations in the WRN gene, which affects DNA repair. WS patients show severe metabolic problems, but the causes are not fully c...

The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Objectives To determine if NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle. Journal The Journal of Phys...

Nicotinamide Riboside Increases Platelet NAD+ but Does Not Extend Their Lifespan: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, has been shown in many studies to extend the lifespan of cells and tissues by improving energy metabolism and ce...

Electrochemical Behavior of Nicotinamide Riboside Reveals Its Activity in Biological Systems: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a popular supplement that boosts NAD+, a molecule important for energy metabolism and functions like vision, hearing, and cognition. NAD+ naturally declines ...