Extracellular NAD+ Broken Down by Human Cells to Maintain Intracellular NAD+ Levels: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and human cells replenish NAD+ by using extracellular precursors like nicotinamide (NAM), nicotinic ac...

Study of Nicotinamide Riboside's Properties and Degradation Kinetics: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 and a precursor to NAD+, shows promise as a therapeutic compound for aging. However, little is known about its physical and chemical prope...

Nicotinamide Riboside Administration Improves Mitophagy and Slows Aging in Werner Syndrome: Preclinical Findings

Synopsis Werner syndrome (WS) is a premature aging disease caused by mutations in the WRN gene, which affects DNA repair. WS patients show severe metabolic problems, but the causes are not fully c...

The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Objectives To determine if NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle. Journal The Journal of Phys...

Nicotinamide Riboside Increases Platelet NAD+ but Does Not Extend Their Lifespan: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, has been shown in many studies to extend the lifespan of cells and tissues by improving energy metabolism and ce...

Electrochemical Behavior of Nicotinamide Riboside Reveals Its Activity in Biological Systems: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a popular supplement that boosts NAD+, a molecule important for energy metabolism and functions like vision, hearing, and cognition. NAD+ naturally declines ...

Nicotinamide Riboside Helps Protect the Heart by Improving Mitochondrial Function: Preclinical Findings

Synopsis Endothelial-to-mesenchymal transition (EndMT) contributes to heart scarring (cardiac fibrosis), but how it happens and how to treat it is not fully known. Researchers found that a process...

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone o...

Effects of High-Dose Nicotinamide Riboside on White Fat Tissue Function and Insulin Sensitivity: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin that helps produce NAD+, a key molecule for metabolism. Although reports of negative effects from high doses of NR are rare, this study examined ho...

Nicotinamide Riboside Protects Against Diet-Induced Liver Injury: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, helps prevent metabolic and age-related disorders in mice, but the role of naturally occurring NR metabolism is less understood. Researche...

NAD+ Levels Control Inflammatory Responses in Immune Cells: Preclinical Findings

SynopsisNAD+ is important for cell metabolism and inflammation, but how it affects immune cells is not well understood. This study looked at how changing NAD+ levels using nicotinamide riboside (NR...

Nicotinamide Ribosides Improves Aerobic Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that helps increase NAD+ and improve mitochondrial function, but its effect on physical fitness is unclear. In a study with sedentary an...

L-Carnitine and Nicotinamide Riboside Reduce Obesity and Liver Fat: Preclinical Findings

Synopsis Obesity and fat buildup in the liver can lead to non-alcoholic fatty liver disease (NAFLD). This study tested whether L-carnitine (LC) and nicotinamide riboside (NR), which support fat me...

Nicotinamide Riboside Supplementation Reverses Aging-Associated NAFLD: Preclinical Findings

Synopsis Aging increases the risk of non-alcoholic fatty liver disease (NAFLD), but the mechanisms are not fully clear. This study tested whether nicotinamide riboside (NR), a precursor to NAD+, c...

Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice: Preclinical Findings

Synopsis This study tested whether nicotinamide riboside (NR) can reduce brain inflammation and improve cognitive function in diabetic mice. Mice with diet- and chemically-induced diabetes were gi...

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...

The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Objectives To test whether NAD+ precursor supplementation with NR affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. Journa...

NAMPT Deficiency in Mouse Liver Cells Shows Minimal Impact on NAD+ and Mitochondrial Health: Preclinical Findings

Synopsis Supplementation with NAD+ precursors such as nicotinamide riboside (NR) has been shown to improve mitochondrial function and prevent liver fat accumulation in high-fat diet (HFD)-fed rode...

Nicotinamide Riboside Protects the Heart from the Cardiotoxic Effects of Doxorubicin, a Chemotherapy Drug: Preclinical Findings

Synopsis Doxorubicin (DOX) is a common chemotherapy drug, but it can seriously damage the heart, partly due to oxidative stress. Normally, heart cells use autophagy to remove damaged components an...

Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety and efficiacy of NR supplementation in overweight, but otherwise healthy men and women. Journal Scientific Reports Key Outcomes NR supplementation significantly ...