Article: Coronavirus Disrupts NAD+ Metabolism, While Nicotinamide Riboside Decreases Viral Replication: Preclinical Findings

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Metabolic Health Obesity Preclinical

Coronavirus Disrupts NAD+ Metabolism, While Nicotinamide Riboside Decreases Viral Replication: Preclinical Findings

Synopsis

Certain enzymes called PARPs, which use NAD+ to modify proteins, play a role in the body’s defense against coronaviruses. Researchers found that SARS-CoV-2 infection increases the levels of specific PARPs involved in antiviral responses and changes how cells produce NAD+. The activity of these PARPs depends on NAD+ availability. When NAD+ levels drop during infection, the antiviral functions of these enzymes are weakened. However, boosting NAD+ levels with NR or NAM reduced coronavirus replication. These findings suggest that supporting NAD+ production could be a way to support the immune response against coronaviruses like COVID-19.

Journal

Journal of Biological Chemistry

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