Article: Adult Zebrafish Provide an In Vivo Platform for Evaluating Drug Responses in Ethanol-Induced Acute Hepatic Injury: Preclinical FIndings

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Liver Health Metabolic Health Preclinical

Adult Zebrafish Provide an In Vivo Platform for Evaluating Drug Responses in Ethanol-Induced Acute Hepatic Injury: Preclinical FIndings

Synopsis

Chronic alcohol use can damage the liver, but effective treatments are limited. Researchers developed an adult zebrafish model to quickly test drugs for alcohol-induced liver injury. Exposing zebrafish to ethanol raised liver enzyme levels (ALT) and triggered inflammation. Supplementing with nicotinamide riboside (NR), which boosts NAD+, or TES-1025, an NAD+ enhancer, reduced ALT levels and inflammation. Riboflavin also helped protect the liver. This study shows that NR can protect against alcohol-related liver damage and demonstrates a cost-effective zebrafish model for testing potential liver therapies.

Journal

Biomedicine & Pharmacotherapy

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