17-α-Estradiol Extends Male Mouse Lifespan, While Nicotinamide Riboside Shows No Significant Effect: Preclinical Findings

Synopsis

In genetically diverse mice, the “non-feminizing” estrogen 17-α-estradiol (17aE2) increased median male lifespan by 19% when started at 16 months and by 11% when started at 20 months. It also reduced body weight by about 20%. In contrast, nicotinamide riboside and three other tested compounds (candesartan cilexetil, geranylgeranylacetone, and MIF098) did not significantly extend lifespan in either males or females at the doses used. These results confirm that 17aE2 provides a strong, late-life lifespan benefit in males, highlighting possible sex-specific mechanisms of aging and the potential for effective late-life interventions.

Journal

Aging Cell