Article: Synthesis and Stability of Dihydronicotinamide Riboside from Nicotinamide Riboside Chloride: Preclinical Findings

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Pharmacokinetic/Safety Preclinical

Synthesis and Stability of Dihydronicotinamide Riboside from Nicotinamide Riboside Chloride: Preclinical Findings

Synopsis

NRH, a highly effective synthetic NAD+ precursor, was produced in high yield from nicotinamide riboside chloride (NRCl) using a water-based reduction process under low-oxygen conditions. The method achieved a 55% yield and 96% purity, confirmed through multiple chemical analyses. NRH was more thermally stable than NRCl but degraded quickly in acidic or oxygen-rich environments. Stability improved in nitrogen, at low temperatures, and under basic pH. This scalable process makes large-scale NRH production more practical.

Journal

RSC Advances

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Muscle Health

The Effects of Nicotinamide Riboside on Color and Color Stability of Pork Chops: Preclinical Findings

SynopsisThis study tested whether nicotinamide riboside (NR) could improve the color and color stability of pork chops from pigs exposed to extreme stress before harvest. One hundred pigs received ...

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Cellular Health

Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

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