Nicotinamide Riboside Protects Retinal Ganglion Cells: Preclinical Findings

Synopsis Glaucoma causes vision loss by damaging retinal ganglion cells (RGCs)—the neurons that carry visual information to the brain. One key cause of this damage is glutamate excitotoxicity, whe...

Nicotinamide Riboside Preserves Retinal Cells and Mitochondrial Function in Glucocorticoid-Induced Glaucomae: Preclinical Findings

SynopsisGlucocorticoid-induced glaucoma (GIG) is a common side effect of steroid use that can cause blindness by damaging the eye's trabecular meshwork (TM), raising eye pressure, and killing retin...

Nicotinamide Riboside Mitigates Oxidative Damage and Fibrosis in Trabecular Meshwork Cells: Preclinical Findings

Synopsis Glaucoma is a leading cause of irreversible blindness, often caused by dysfunction and scarring in the trabecular meshwork (TM)—the eye tissue that regulates fluid drainage and intraocula...

Nicotinamide Riboside Protects Retinal Nerve Cells in Glaucoma: Preclinical Findings

SynopsisGlaucoma causes progressive retinal ganglion cell (RGC) degeneration and vision loss, often associated with elevated intraocular pressure (IOP). This study tested whether oral administratio...

Nicotinamide Riboside Treatment Protects Retinal Cells in Mice: Preclinical Findings

SynopsisGlaucoma often involves death of retinal ganglion cells (RGCs), partly caused by high eye pressure (IOP). But even when IOP is controlled, the disease can still worsen. So, it's important t...

SARM1 Drives Nerve Damage Following Inflammation and Cell Death Signals: Preclinical Findings

SynopsisNeuroinflammation and a type of cell death called necroptosis play big roles in neurodegenerative diseases, often starting with damage to nerve fibers called axons. SARM1 is a key enzyme th...