NAD+ Depletion Drives Cartilage Damage in Osteoarthritis: Preclinical Findings

Synopsis Earlier research showed that people with osteoarthritis (OA) have lower levels of NAD+, an important energy-related molecule, in their cartilage. This study found that NAD+ levels are red...

Nicotinamide Riboside Restores Bone Health in Glucocorticoid-Induced Osteoporosis: Preclinical Findings

Synopsis Glucocorticoid-induced osteoporosis (GIOP) is a major side effect of long-term steroid use, caused by damage to osteoblasts—the bone-forming cells. Recent studies show that ferroptosis, a...

Nicotinamide Riboside Alleviates Bone Cancer Pain by Restoring Mitochondrial Function: Preclinical Findings

Synopsis Bone cancer pain (BCP) disrupts mitochondrial function in spinal cord neurons, leading to damaged mitochondrial structure, reduced ATP production, and decreased membrane potential (MMP). ...

Nicotinamide Riboside Mitigates Diabetes-Related Bone Loss: Preclinical Findings

Synopsis Type 2 diabetes mellitus (T2DM) caused by high-fat diet/streptozotocin treatment led to impaired bone microarchitecture and bone loss in mice, along with metabolic dysfunction. Supplement...

Nicotinamide Riboside Protects Bones via Mitochondrial Support: Preclinical Findings

Synopsis This study uncovered how gut microbiota imbalances contribute to osteoporosis through the overproduction of trimethylamine-N-oxide (TMAO), a metabolite formed from L-carnitine by intestin...

Nicotinamide Riboside Protected Muscle Cells from Heat-Induced Injury: Preclinical Findings

Synopsis Prolonged exposure to heat stress can damage skeletal muscle (SKM) by disrupting mitochondrial function, but the mechanisms behind this injury are not fully understood. This study found t...

Nicotinamide Riboside Slows Intervertebral Disc Degeneration: Preclinical Findings

Synopsis Intervertebral disc degeneration (IVDD) is a common age-related condition that causes chronic back pain and reduced mobility. This study investigated how nicotinamide riboside (NR)—a vita...

Nicotinamide Riboside Attenuates Inflammation and Promotes Functional Recovery After Spinal Cord Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), levels of nicotinamide adenine dinucleotide (NAD+)—a vital molecule for energy metabolism and cell repair—drop significantly, contributing to inflammatio...

Nicotinamide Riboside and Resveratrol Rejuvenate Stem Cells and Enhance Bone Regeneration in Aging: Preclinical Findings

Synopsis Age-related bone loss is a major cause of disability in older adults, largely due to the aging and dysfunction of bone marrow mesenchymal stem cells (MSCs)—the cells responsible for bone ...

Nicotinamide Riboside Ameliorates Joint Damage and Inflammation in Knee Osteoarthritis: Preclinical Findings

Synopsis Knee osteoarthritis (KOA) is a common condition that causes joint pain and stiffness due to cartilage breakdown and inflammation. This study compared the effects of nicotinamide riboside ...

Nicotinamide Riboside Supports Cartilage Cell Survival and Normal Bone Growth: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is critical for energy metabolism and bone development. Researchers generated mice lacking NAMPT, an essential enzyme in the NAD+ salvage pathway,...

Nicotinamide Riboside Maintains Mitochondrial Health in Intervertebral Disc Degeneration: Preclinical Findings

Synopsis This study explored how the mitochondrial unfolded protein response (UPRmt) protects cells in the intervertebral disc from damage by activating mitophagy, the process that clears defectiv...

Nicotinamide Riboside Activates Mitochondrial Stress Response to Protect Against Osteoarthritis: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) is a protective system that helps mitochondria—the cell’s energy centers—function properly when damaged or stressed. Healthy mitochondr...

Nicotinamide Riboside Restores NAD+ and Prevents Age-Related Bone Loss: Preclinical Findings

SynopsisAge-related osteoporosis happens because of a decline in osteoblasts—the cells that build bone—and fewer osteoblast progenitor cells, which show signs of aging called senescence. FoxO trans...