Safety of Nicotinamide Riboside Injections: Clinical Findings

Objectives To assess intravenous, sub-Q, or IM NR injection tolerability and monitor adverse events, vital signs, and laboratory safety measures. Journal medRxiv Key Outcomes Across both studies,...

Topical Nicotinamide Riboside Improves Skin Hydration and Redness: Clinical Findings

Objectives To assess the irritation potential and short-term effects of topical NR administration on hydration, redness, glossiness, and skin-barrier measures. Journal Preprints Key Outcomes NR a...

Nicotinamide Riboside Increases NAD+ More Than NMN: Clinical Findings

Objectives To investigate the blood and brain pharmacokinetics of NR and NMN in healthy individuals and PD patients. Journal iScience Key Outcomes During the pilot portion, NR supplementation did...

Differential Effects of NR, NMN, and Nicotinamide on NAD+ and Microbial Metabolism: Clinical Findings

Objectives To compare the effects of NR, NMN, and NAM on NAD+ levels and investigate how gut microbes metabolize each precursor. Journal Nature Metabolism Key Outcomes NR and NMN produced similar...

Real-World Tolerability of Intravenous Infusion of NAD+ vs. NR: Clinical Findings

Objectives To compare commercially administered NAD+ IV and NR IV in humans by evaluating infusion time, tolerability, safety markers, and metabolic outcomes. Journal Frontiers in Aging Key Outcom...

Safety of Intravenous Nicotinamide Riboside Across Multiple Doses in Rats: Preclinical Findings

Synopsis This study evaluated the safety of repeated intravenous nicotinamide riboside (NR) at varying doses in Wistar rats. NR was well-tolerated at 150, 300, and 450 mg/kg, with no adverse effec...

Nicotinamide Riboside: Review

SynopsisNicotinamide riboside (NR) is a well-studied NAD+ precursor with multiple health benefits linked to increasing NAD+ levels in the body. Studies in animals and humans show NR may help treat ...

Niagen® IV (NR IV) Is Safer, Faster, and More Effective Than NAD+ IV at Raising NAD+ Levels

Objectives To assess the safety and efficacy of a single intravenous administration of NR compared to NAD+ and a saline control in terms of whole blood NAD+ changes, tolerable infusion rates, and ...

High-Dose Nicotinamide Riboside Supplementation Provides Benefits in Parkinson’s Disease: Clinical Findings

Objectives To assess the safety of high-dose NR through the absence of clinically significant adverse events, and assess short-term tolerability and impacts on NAD+, as well as clinical severity o...

Acute Effects of Combined Metabolic Activators and NAD+ Precursors on NAD+ Metabolites: Clinical Findings

Objectives To investigate the safety and acute effects of six different combined metabolic activators (CMA) formulations, each containing 1000 mg of one of the following NAD+ precursors: nicotinam...

Synthesis and Stability of Dihydronicotinamide Riboside from Nicotinamide Riboside Chloride: Preclinical Findings

SynopsisNRH, a highly effective synthetic NAD+ precursor, was produced in high yield from nicotinamide riboside chloride (NRCl) using a water-based reduction process under low-oxygen conditions. Th...

Nanocrystal Nicotinamide Riboside Improves Absorption and Protects the Heart: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative that boosts NAD+ to support mitochondrial energy, often loses effectiveness when taken orally because it breaks down too quickly in the...

Nicotinamide Riboside and Pterostilbene Increase NAD+ Levels in Patients with Acute Kidney Injury: Clinical Findings

Objectives To evaluate the effects of escalating doses of nicotinamide riboside and pterostilbene (NRPT) on blood NAD+ levels and safety outcomes in patients hospitalized with acute kidney injury ...

Safety Evaluation of Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Oral Toxicity Study: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that boosts NAD+ levels and may help counter age-related declines in cellular energy. This study tested the safety of a high-purity, syn...

Nicotinamide Riboside—Therapeutic Applications and Current State of Research: Review

SynopsisNicotinamide riboside (NR) is a form of vitamin B3 and a building block for NAD+, a coenzyme essential for energy production, DNA repair, and cell communication. NR has gained attention for...

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy h...

Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety and efficiacy of NR supplementation in overweight, but otherwise healthy men and women. Journal Scientific Reports Key Outcomes NR supplementation significantly ...

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults. Journal Nature Communications Key Outcomes NR ...

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...