Unique Mutations in Mouse Hepatitis Virus Reduce Virus Replication: Preclinical Findings

SynopsisAll coronaviruses contain a small domain called the macrodomain, or Mac1, within the nonstructural protein 3 (nsp3). Mac1 binds to and removes a molecule called mono-ADP-ribose (MAR) that a...

Nicotinamide Riboside Restores NAD+ Metabolism and Improves Recovery in COVID-19: Preclinical Findings

SynopsisSevere COVID-19 initially causes lung infection and inflammation. Some patients develop Post-Acute Sequelae of COVID (PASC), experiencing ongoing lung problems, fatigue, and cognitive issue...

Nicotinamide Riboside and Nicotinamide Mononucleotide Prevent Oxidative Stress in Blood Vessel Cells From COVID-19 Patients: Preclinical Findings

SynopsisCOVID-19 is associated with vascular endothelial dysfunction, but mechanisms remain unclear. This study exposed human aortic endothelial cells (HAECs) to plasma from hospitalized COVID-19 p...

NAD+ Biosynthesis Enzyme Protects Aortic Smooth Muscle Cells: Preclinical Findings

Synopsis The walls of the aorta weaken with age and stress, risking serious damage. Smooth muscle cells (SMCs) in the aorta need NAD+, made by the enzyme NAMPT, for health. In humans with aortic d...

Nicotinamide Riboside Supplementation Combined with Other Nutrients Accelerates Recovery in COVID-19 Patients: Clinical Findings

Objectives To investigate supplementation of the combined metabolic activators (CMA), consisting of L-serine, N-acetyl-L-cysteine (NAC), NR, and L-carnitine tartrate for the treatment of patients ...