Nicotinamide Riboside Increases NAD+ Levels and Improves Symptom Recovery in Long COVID: Clinical Findings

Objectives To investigate the effects of NR supplementation on NAD+ levels, cognitive function, and long COVID symptoms in non-hospitalized individuals with long COVID.  Journal The Lancet eClinic...

Nicotinamide Riboside Increases Stress Sensitivity and Alters Blood Cell Composition in Aging: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a precursor to NAD⁺, a key molecule for cellular energy that declines with age. Aging can cause reduced brain and immune function, changes in blood, and greate...

Nicotinamide Riboside Enhances NK Cell Anti-Tumor Activity: Preclinical Findings

Synopsis Tumor-produced lactate weakens natural killer (NK) cells by causing lysine lactylation (Kla), disrupting NAD+ metabolism, and fragmenting mitochondria, which reduces cytotoxicity. Supplem...

Nicotinamide Riboside and NMN Enhance CAR-T Cell Function in Aging: Preclinical Findings

Synopsis Chimeric antigen receptor (CAR) T cell therapy is a powerful cancer treatment, but its effectiveness declines with aging. This study found that CAR-T cells from aged female mice show mito...

Nicotinamide Riboside Enhances T Cell Function and Antitumor Immunity: Preclinical Findings

Synopsis Most current cancer immunotherapies mainly focus on activating type 1 immune responses, which help fight cancer, but long-term remission is rare. Our study shows that a type 2 immune prot...

Nicotinamide Riboside Helps Improve Symptoms in Lupus: Preclinical Findings

SynopsisThe protein PPP2R2A helps regulate the immune system, and in lupus-prone mice, T cells lacking this protein caused less autoimmunity and kidney damage. Without PPP2R2A, T cells produced mor...

Nicotinamide Riboside and Pterostilbene Prevent UVB-Induced Skin Swelling and Immune Suppression: Preclinical Findings

Synopsis Exposure to ultraviolet B (UVB) radiation can cause skin inflammation, immune suppression, and long-term risks like skin cancer. This study tested whether nicotinamide riboside (NR), a vi...

Nicotinamide Riboside Supplementation Supports Immune Regulation in Human Cells and Blood: Clinical Findings

Objectives To investigate how NR influences the migration of macrophages and the underlying mechanisms behind this effect. Journal Cells Key Outcomes Ex Vivo: NR treatment increased levels of NA...

Role of nadR Gene in Growth and Virulence of Streptococcus suis Bacteria: Preclinical Findings

SynopsisStreptococcus suis serotype 2 (SS2) is a harmful bacterium in pigs that can also infect humans. This study investigated the role of the nadR gene, which helps make and transport NAD+ inside...

Effects of Nicotinamide Riboside on Bacterial Respiratory Epithelial Infections: Preclinical Findings

Synopsis This study found that during infection, lung cells experience a breakdown in the NAD+ salvage pathway, which reduces NAD+ production—a molecule crucial for energy metabolism and immune de...

Nicotinamide Riboside and Nicotinamide Mononucleotide Prevent Oxidative Stress in Blood Vessel Cells From COVID-19 Patients: Preclinical Findings

SynopsisCOVID-19 is associated with vascular endothelial dysfunction, but mechanisms remain unclear. This study exposed human aortic endothelial cells (HAECs) to plasma from hospitalized COVID-19 p...

Nicotinamide Riboside Supplementation Reduces Inflammatory Markers in Immune Cells from Healthy Subjects and Psoriasis Patients: Clinical Findings

Objectives To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in viv...

Nicotinamide Riboside Reduces T Cell Exhaustion and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening response to infection, often causes the immune system to weaken through T cell exhaustion, leading to poor recovery and high mortality. This study found that in...

Nicotinamide Riboside Restores NAD+ Metabolism and Improves Recovery in COVID-19: Preclinical Findings

SynopsisSevere COVID-19 initially causes lung infection and inflammation. Some patients develop Post-Acute Sequelae of COVID (PASC), experiencing ongoing lung problems, fatigue, and cognitive issue...

Nicotinamide Riboside Protects Against Ovarian Injury in Sepsis: Preclinical Findings

Synopsis This study examined whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, can protect against oxidative stress and tissue injury caused by sepsis in rats. Researchers cre...

Nicotinamide Riboside Hydrogel Enhances T Cell Therapy: Preclinical Findings

Synopsis T cell-based immunotherapy (TCBI) is a promising cancer treatment, but its success is often limited by weak immune activation, T cell exhaustion, and tumor immune evasion through the PD-1...

Nicotinamide Riboside Ameliorates Inflammation and Joint Damage in Rheumatoid Arthritis: Preclinical Findings

Synopsis This study investigated how NAD+ metabolism affects rheumatoid arthritis (RA) and whether NAD+ boosters could improve disease outcomes. Researchers analyzed blood samples from 253 partici...

Interferon-β in Combination with Nicotinamide Riboside Offers Protection Against Sepsis: Preclinical Findings

Synopsis Sepsis is a severe, often fatal condition in which the body’s immune response to infection causes widespread inflammation and organ failure. This study found that combining interferon-β (...

Nicotinamide Riboside Restores NAD+ and Counters Tumor Hyperprogression: Preclinical Findings

Synopsis Immune checkpoint blockade (ICB) therapy can sometimes cause tumors to grow faster, a problem called hyperprogressive disease (HPD). This study found that when immune cells release interf...

Emerging Role of Nicotinamide Riboside in Health and Diseases: Review

SynopsisAmong NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has ...