Article: Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

PrevNext
Cardiovascular Disease Cardiovascular Health Mitochondrial Health Preclinical

Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

Synopsis

Poly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial function. In a mouse model with high mitochondrial DNA damage, NAD+ loss reduced activity of the mitochondrial regulator SIRT3. High doses of NR in this context worsened problems by causing nicotinamide buildup, further blocking sirtuins and altering mitochondrial structure. This suggests that while NR can be beneficial, high doses should be used cautiously when mitochondrial DNA instability is present.

Journal

eLife

Share

Read more

COVID/Long-COVID

Unique Mutations in Mouse Hepatitis Virus Reduce Virus Replication: Preclinical Findings

SynopsisAll coronaviruses contain a small domain called the macrodomain, or Mac1, within the nonstructural protein 3 (nsp3). Mac1 binds to and removes a molecule called mono-ADP-ribose (MAR) that a...

Read more
Cardiovascular Disease

Nicotinamide Riboside Reduces Heart Damage in Presence of Fentanyl, Midazolam, and Cangrelor: Preclinical Findings

SynopsisWhen blood flow to the heart is blocked and then restored—a process called ischemia-reperfusion injury—cells can be severely damaged. Researchers tested several potential protective compoun...

Read more