Nicotinamide Riboside May Help Reactivate Early Human Embryos in IVF: Preclinical Findings

Synopsis During in vitro fertilization (IVF), nearly 60% of human embryos stop developing early—between the 3- and 8-cell stages—making it a major challenge for successful pregnancies. This study ...

CD38 Inhibitor MK-0159 Preserves NAD+ and Protects the Heart From Ischemia/Reperfusion Injury: Preclinical Findings

Synopsis The enzyme CD38 breaks down important molecules like NAD+ and NADP+, which are vital for cellular energy production and mitochondrial health. When CD38 activity increases—such as during a...

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

Nicotinamide Riboside and Caffeine Partially Increase Energy in Alzheimer’s Disease: Preclinical Findings

Synopsis As people age, levels of NAD+, a key molecule for energy production, decline, and low NAD+ is linked to energy problems in late-onset Alzheimer’s disease (LOAD). This study tested whether...

Nicotinamide Riboside and Pterostilbene Therapy Improves Cell Metabolism and Shows Promise in ALS: Preclinical Findings

Synopsis Researchers studying amyotrophic lateral sclerosis (ALS) found that not all patients share the same metabolic profile, meaning their cells process energy differently. In particular, one s...

Early-Life Nicotinamide Riboside Supplementation Protects Against Obesity and Fatty Liver: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, is known for its anti-aging and metabolic health benefits, but its long-term effects when given early in life are l...

Nicotinamide Riboside Prevents Nerve Damage From Toxic Chemicals: Preclinical Findings

Synopsis Organophosphate-induced delayed neuropathy (OPIDN) is a serious condition caused by exposure to certain toxic chemicals, leading to nerve degeneration similar to Wallerian degeneration, w...

Autism-Linked Gene NRXN1 Found to Affect Mitochondrial Energy and Metabolism: Preclinical Findings

Synopsis Autism is often linked to differences in language, social interaction, and repetitive behaviors, but it is increasingly recognized that energy metabolism and mitochondrial dysfunction can...

Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings

SynopsisNR supplementation was tested in young and old obese female mice to see if it reduces liver inflammation and fibrosis. In old mice, NR decreased weight gain, fat mass, and improved glucose ...

Nicotinamide Riboside Restores Memory and Protects the Brain After Stroke: Preclinical Findings

Synopsis After a stroke, the brain suffers from a sudden loss of blood flow that damages neurons and causes memory problems. This study found that treating mice with nicotinamide riboside chloride...

Resveratrol and Dimethyl Fumarate Combination Therapy Shows Promise in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FA) is a rare inherited disorder that affects the nervous system and heart, with no approved therapies yet. Researchers tested eight compounds—including nicotinamide ...

Nicotinamide Riboside and Natural Antioxidants Protect Against Radiation Damage and Improve Survival: Preclinical Findings

Synopsis Researchers tested whether natural compounds could protect against harmful ionizing radiation, which has applications in medicine, space travel, and biotechnology. In mice exposed to leth...

Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

Synopsis The circadian clock, which regulates daily biological rhythms, also plays an important role in heart health. In this study, mice lacking REV-ERB receptors—key circadian regulators in the ...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

Nicotinamide Riboside Protects Against Experimental Necrotizing Enterocolitis: Preclinical Findings

Synopsis Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease that affects newborns, often due to oxidative stress and poor blood flow in the gut. This study found that nicotin...

Nicotinamide Riboside Protects Cells From Oxidative Damage: Preclinical Findings

Synopsis Oxidative stress, caused by an overload of reactive oxygen species, can make cells die either by apoptosis (a controlled process) or necrosis (an uncontrolled one). Scientists found that ...

NAD+ Precursors Prevent Allergic Responses by Regulating Immune Function: Preclinical Findings

Synopsis Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—both vitamin B3 derivatives that boost NAD+ levels—may help prevent severe allergic reactions such as anaphylaxis. In this...

Nicotinamide Riboside and NMN Enhance Regeneration of Lung Cells in 3D Culture: Preclinical Findings

Synopsis Type 2 alveolar epithelial cells (AEC2s) are crucial for repairing and regenerating lung tissue after injury. This study found that in both idiopathic pulmonary fibrosis (IPF) patients an...

Nicotinamide Riboside Improves Vascular Health and Reduces Inflammation in Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of plaques in arteries, begins with endothelial cell dysfunction and inflammation triggered by high cholesterol. This study found that loss of SIRT3, a mitoch...

Effects of Nicotinamide Riboside on Exercise Performance: Preclinical Findings

Synopsis This proof-of-concept study tested whether chronic nicotinamide riboside (NR) supplementation, a precursor of nicotinamide adenine dinucleotide (NAD+), could enhance physical performance ...