Nicotinamide Riboside Helps Improve Symptoms in Lupus: Preclinical Findings

SynopsisThe protein PPP2R2A helps regulate the immune system, and in lupus-prone mice, T cells lacking this protein caused less autoimmunity and kidney damage. Without PPP2R2A, T cells produced mor...

Nicotinamide Riboside Supplementation Increases Brain NAD+ Levels in Humans: Clinical Findings

Objectives To investigate the effects of acute NR supplementation on cerebral NAD+ levels in the healthy human brain using a specialized MRI technique called downfield proton magnetic resonance sp...

Nicotinamide Adenine Dinucleotide Precursors and Their Role in Ovarian Health: Review

SynopsisNatural NAD⁺ precursors may support ovarian health, but their tissue targets, efficiency, and side effects vary. This review outlines NAD+'s distribution inside and outside cells, its compl...

Nicotinamide Riboside Extends Lifespan and Restores Cardiac Function in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FRDA) is a rare inherited disease caused by reduced production of frataxin, a mitochondrial protein essential for iron-sulfur cluster formation. The condition leads t...

Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Senescence: Preclinical Findings

Synopsis Radiation therapy for cancer often damages the intestines, leading to long-term side effects known as delayed effects of acute radiation exposure (DEARE). This study investigated whether ...

Nicotinamide Riboside Reduces Oxidative Stress in Alzheimer's Disease: Preclinical Findings

Synopsis Mitophagy—the process by which damaged mitochondria are removed—is essential for maintaining brain cell health and preventing neurodegeneration. In this study, researchers examined fibrob...

Nicotinamide Riboside Protects Mitochondria in Aging Kidneys: Preclinical Findings

SynopsisAs kidneys age, their cells, especially in the distal tubules, undergo changes in mitochondrial structure and function, but little is known about how aging or anti-aging interventions affec...

Effects of Nicotinamide Riboside on Lung Cells: Preclinical Findings

Synopsis This study examined how different concentrations of nicotinamide riboside (NR)—a vitamin B3–derived NAD+ precursor—affect human lung cells grown in both 2D and 3D cultures. Researchers fo...

Nicotinamide Riboside Protects Against Brain Injury in Intracerebral Hemorrhage: Preclinical Findings

Synopsis Hemorrhagic stroke, caused by bleeding within the brain, is a severe condition with high disability and death rates. This study examined whether nicotinamide riboside (NR)—a vitamin B3–de...

Effects of Nicotinamide Riboside on Mitochondrial Health and Dopamine in Parkinson's Disease: Preclinical Findings

SynopsisParkinson's disease (PD) involves mitochondrial dysfunction, reduced proteasome activity, and dopamine depletion. NR activated mitochondrial function in C. elegans, rescuing α-synuclein-rel...

Nicotinamide Riboside Protects Against Maternal Acetaminophen Exposure: Preclinical Findings

Synopsis Acetaminophen (APAP) is widely used by pregnant women to relieve pain and fever, but recent evidence suggests it may harm fetal development, especially during the sensitive period of egg ...

Nicotinamide Riboside Preserves Retinal Cells and Mitochondrial Function in Glucocorticoid-Induced Glaucomae: Preclinical Findings

SynopsisGlucocorticoid-induced glaucoma (GIG) is a common side effect of steroid use that can cause blindness by damaging the eye's trabecular meshwork (TM), raising eye pressure, and killing retin...

Nicotinamide Riboside Promotes Spinal Cord Repair: Preclinical Findings

Synopsis Repairing the spinal cord after injury is extremely difficult because nerve cells do not easily regenerate. One promising strategy is to activate endogenous neural stem cells (NSCs)—the b...

Nicotinamide Riboside Improves Survival and Motor Function in Parkinson’s Disease: Preclinical Findings

Synopsis Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons, leading to motor dysfunction and other symptoms. This study investigated how nic...

Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD). Journal Natur...

A Novel Ketogenic Diet Reduces Seizure Severity and Prevents Fatty Liver in Epileptogenesis: Preclinical Findings

Synopsis Drug-resistant epilepsy remains difficult to manage, and while the ketogenic diet (KD) can help reduce seizures, its high fat content often causes metabolic side effects and poor patient ...

Niagen® IV (NR IV) Is Safer, Faster, and More Effective Than NAD+ IV at Raising NAD+ Levels

Objectives To assess the safety and efficacy of a single intravenous administration of NR compared to NAD+ and a saline control in terms of whole blood NAD+ changes, tolerable infusion rates, and ...

Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

Treatment with Bezafibrate and Nicotinamide Riboside Temporarily Stabilizes Cardiovascular Health in Complex I Deficiency: Case Report

Objectives To evaluate the effects of high-dose bezafibrate and NR administration in treating an infant with mutations in the ACAD9 gene, resulting in ACAD9-related complex I deficiency. Journal M...

In Ovo Nicotinamide Riboside Feeding Increases Muscle Mass and Fiber Number in Broiler Chickens: Preclinical Findings

SynopsisThis study examined the effects of in ovo nicotinamide riboside (NR) feeding on growth and meat quality in high-yield broilers. Fertilized Cobb 700 eggs were randomly assigned to four treat...