Autophagy Promotes Cell Survival by Maintaining Stable NAD+ Levels: Preclinical Findings

SynopsisAutophagy is a cellular process that removes damaged parts of the cell and is important for healthy aging. When autophagy is lost, NAD+ levels fall due to increased activity of enzymes that...

Altered NAD+ and Glutathione Metabolism in Fatty Liver Disease: Preclinical Findings

SynopsisIn patients with non-alcoholic fatty liver disease (NAFLD), researchers identified altered liver metabolism, specifically increased demand for NAD+ and glutathione (GSH), a key antioxidant....

17-α-Estradiol Extends Male Mouse Lifespan, While Nicotinamide Riboside Shows No Significant Effect: Preclinical Findings

SynopsisIn genetically diverse mice, the “non-feminizing” estrogen 17-α-estradiol (17aE2) increased median male lifespan by 19% when started at 16 months and by 11% when started at 20 months. It al...

A New Bioluminescent Probe to Monitor Mitochondrial Health Over Time: Preclinical Findings

SynopsisMitochondrial membrane potential (ΔΨm) is a key indicator of mitochondrial health and is involved in diseases like diabetes, cancer, Alzheimer’s, and Parkinson’s. This study introduces a ne...

Nicotinamide Riboside-Containing β-Hydroxybutyrate Supplementation (NHS101) in Children with Multiple Acyl-CoA Dehydrogenase or Pyruvate Dehydrogenase Deficiency: Case Report

Objective To evaluate the efficacy of a new preparation of dextro-β hydroxybutyrate salt mixture containing NR (NHS101) in patients with metabolic disorders affecting energy metabolism, specificall...

Early Nicotinamide Riboside Supplementation Shows Promise in an Individual with Ataxia Telangiectasia: Case Report

Objective To investigate the effects of NR supplementation in a 3.5-year-old male child with ataxia and recurrent bacterial infections. This was a case study of one individual. Key Outcomes NR su...

The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Objectives To determine if NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle. Journal The Journal of Phys...

Nicotinamide Riboside Supplementation Enhances NAD+ Metabolism in Ataxia Telangiectasia: Clinical Findings

Objectives To study the metabolic effects of treatment with NR in a cohort of patients with ataxia-telangiectasia (AT). Journal Metabolites Key Outcomes NR-related pathways and metabolites signif...

Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings

Objectives To evaluate whether combining aerobic exercise with nicotinamide riboside (NR) could enhance blood pressure (BP) control in sedentary older adults with hypertension. Journal GeroScience...

Study of Nicotinamide Riboside's Properties and Degradation Kinetics: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 and a precursor to NAD+, shows promise as a therapeutic compound for aging. However, little is known about its physical and chemical prope...

Mild Vitamin B3 Deficiency Changes Gene Activity in White Fat Tissue: Preclinical Findings

Synopsis Mild vitamin B3 (niacin) deficiency is hard to detect. This study compared mice fed a diet without NR (vitamin B3 precursor) to those given recommended B3 levels, both with low tryptophan...

Nicotinamide Riboside Improves Mitochondrial Defects and Neuronal Loss in Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial problems are thought to play a major role in Parkinson’s disease (PD), but it’s unclear if fixing them can slow the disease. Using patient-derived stem cells and fruit fly m...

Nicotinamide Riboside Enhances Blood Stem Cell Recovery and Regeneration: Preclinical Findings

Synopsis Recent studies show that increased mitochondrial activity and impaired stress response harm hematopoietic stem cells (HSCs), reducing their ability to regenerate. This study found that NR...

NAD+ Restores Heart Function in Heart Failure via Ketone Production: Preclinical Findings

Synopsis Heart failure with preserved ejection fraction (HFpEF) is a common form of heart failure with few treatment options. This study found that the heart can make ketones using the enzyme HMGC...

Nicotinamide Riboside Restores NAD+ Levels and Improves Metabolism in Diastolic Heart Failure: Preclinical Findings

Synopsis Heart failure with left ventricular diastolic dysfunction is a growing health problem worldwide. This study looked at levels of NAD+, a key metabolic cofactor, in the hearts of patients w...

Nicotinamide Riboside Prevents Hearing Loss in Cockayne Syndrome: Preclinical Findings

Synopsis Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are curr...

Nicotinamide Mononucleotide Improves Blood Vessel Function by Converting to Nicotinamide Riboside: Preclinical Findings

Synopsis Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are compounds that help make NAD+, which may protect blood vessels. Researchers studied how NMN and NR affect inflammation...

Nicotinamide Riboside Restores NAD+ Levels and Improves Heart Function in Cardiomyopathy: Preclinical Findings

Synopsis Cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy) leads to heart muscle and electrical dysfunction, often resulting in heart failure. Currently, there is no t...

Fixing Imbalanced NAD Metabolism Reduces Effects of Telomere Dysfunction: Preclinical Findings

Synopsis Short telomeres cause diseases like dyskeratosis congenita (DC), which lack effective treatments. This study found that cells from DC patients and telomerase-deficient mice have low NAD+ ...

Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to redu...