Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Injury: Preclinical Findings

Synopsis Radiation-induced intestinal injury (IR) is a major complication of colorectal cancer radiotherapy. This study shows that nicotinamide riboside (NR) markedly reduces IR severity in mice, ...

Nicotinamide Riboside Plus Magnesium-L-Theanine Protects Against Stress-Induced Gut–Liver Injury: Preclinical Findings

Synopsis Chronic stress can harm the gut and liver by disrupting metabolism and causing oxidative damage. This study tested the protective effects of nicotinamide riboside (NR) and magnesium-L-the...

Nicotinamide Riboside Protects the Intestinal Barrier From Heat Stress: Preclinical Findings

Synopsis Heat stress damages the intestinal epithelial barrier, allowing harmful substances to enter the body. This study tested whether nicotinamide riboside (NR), a NAD+ precursor, could protect...

Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Senescence: Preclinical Findings

Synopsis Radiation therapy for cancer often damages the intestines, leading to long-term side effects known as delayed effects of acute radiation exposure (DEARE). This study investigated whether ...

Nicotinamide Riboside Reduces Colitis Severity in Inflammatory Bowel Disease: Preclinical Findings

Synopsis The gut microbiome produces thousands of metabolites—small molecules that influence inflammation, immunity, and disease. To better understand their roles in inflammatory bowel disease (IB...

Nicotinamide Riboside Ameliorates Senescence-Associated Alterations in Gastric Parietal Cells: Preclinical Findings

Synopsis Aging causes widespread cellular decline, including in the gastrointestinal (GI) tract, where reduced digestive function and nutrient absorption often occur. This study examined how aging...

Nicotinamide Riboside Restores Intestinal Health and Mitochondrial Function in Colitis: Preclinical Findings

SynopsisReduced levels of PGC1α, a key regulator of cellular energy, contribute to inflammatory bowel disease (IBD). In both mice with experimental colitis and humans with ulcerative colitis, NAD+ ...

Nicotinamide Riboside Supplementation May Influence Bacterial Composition: Clinical Findings

Objectives To explore the effects of NR supplementation on the gut microbiota composition in humans. Journal npj Aging Key Outcomes NR supplementation did not affect the diversity or abundance of...

Nicotinamide Riboside and Calorie Restriction Improve Gut Microbiota and Reduce Liver Fat and Inflammation: Preclinical Findings

SynopsisMetabolic dysfunction–related fatty liver disease currently has no specific therapy. This study tested nicotinamide riboside (NR) and dietary restriction (DR) in rats with diet-induced obes...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Nicotinamide Riboside Protects Intestinal Barrier From Alcohol Damage by Supporting Mitochondrial Function: Preclinical Findings

SynopsisThe intestinal barrier, made up of epithelial tight junctions, prevents harmful substances in the gut from entering the bloodstream. When this barrier is damaged, it can cause widespread in...

Nicotinamide Riboside and Metabolic Cofactors Improve Gut Health in Fatty Liver Disease: Preclinical Findings

SynopsisThe gut barrier controls what passes into the body and protects organs like the liver. An unhealthy diet and lifestyle cause gut microbiome imbalances (dysbiosis) and gut barrier damage, wh...

Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

SynopsisAlzheimer's disease (AD) is associated with gut microbiota imbalances. In APP/PS1 transgenic AD mice, gut microbiome diversity was reduced and composition altered compared to wild-type mice...

Nicotinamide Riboside and Derivatives Alter Intestinal Membrane Function and Gut Microbiome: Preclinical Results

SynopsisResearchers synthesized two new nicotinamide riboside (NR) derivatives—one water-soluble and one oil-soluble—and tested them alongside NR in chick embryos. NR and derivatives altered intest...

Nicotinamide Riboside Protects Against Experimental Necrotizing Enterocolitis: Preclinical Findings

Synopsis Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease that affects newborns, often due to oxidative stress and poor blood flow in the gut. This study found that nicotin...

Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings

SynopsisThe gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice...

Nicotinamide Riboside Protects Against Alcohol-Induced Depression via the Gut-Brain Axis: Preclinical Findings

Synopsis The gut microbiome influences brain health and mood, and nicotinamide riboside (NR) has shown neuroprotective effects. This study tested whether NR could prevent alcohol-induced depressio...

Nicotinamide Riboside Prevents Gut Damage After Ischemia: Preclinical Findings

Synopsis Acute mesenteric ischaemia happens when blood flow to the intestines is blocked, which can cause tissue damage and even gangrene. This condition is rare but can be life-threatening. Besid...