Is NAD+ a Key Factor in Ovarian Aging and Dysfunction? Current Insights and Uncertainties: Review

SynopsisRecent studies highlight NAD+ as a key player in energy metabolism, stress response, and aging, and boosting NAD+ may help treat female infertility. This review explores how NAD+ works in t...

Nicotinamide Riboside Enhances Milk Production in Lactating Sows: Preclinical Findings

Synopsis Lactation insufficiency is a common challenge with unclear biological causes. This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, influences mammary g...

Nicotinamide Riboside Protects Against Heat Stress–Induced Testicular Damage and Improves Boar Fertility: Preclinical Findings

Synopsis Heat stress (HS) from rising global temperatures negatively affects male fertility, damaging the testes and reducing semen quality. This study examined how HS alters testicular NAD+ metab...

Nicotinamide Riboside Prevents Oocyte Quality Loss in Maternal Diabetes: Preclinical Findings

Synopsis Diabetes reduces NAD+ levels in ovaries and oocytes, leading to poor oocyte quality, abnormal spindle formation, excess ROS, and impaired embryo development. In streptozotocin-induced dia...

Nicotinamide Riboside Counteracts Testicular Aging: Preclinical Findings

Synopsis Deleting Qprt, a key enzyme in the NAD+ de novo synthesis pathway and highly expressed in spermatocytes, did not disrupt NAD+ levels or spermatogenesis in young (3-month-old) mice. Howeve...

Nicotinamide Riboside Improves Ovarian Function in PCOS: Preclinical Findings

Synopsis In a DHEA-induced mouse model of polycystic ovary syndrome (PCOS), ovarian NAD+ levels dropped sharply, leading to mitochondrial dysfunction in granulosa cells, stromal cells, and oocytes...

Nicotinamide Riboside Preserves Oocyte Quality and Prevents Postovulatory Aging: Preclinical Findings

Synopsis After ovulation, oocytes (eggs) begin to age, leading to lower fertilization success and embryo quality during assisted reproductive technologies (ART) such as IVF. This process, known as...

NAD+ Depletion Is Central to Placental Dysfunction in an Inflammatory Subclass of Preeclampsia: Preclinical Findings

Synopsis Preeclampsia (PE) is a dangerous pregnancy complication marked by high blood pressure, inflammation, and placental dysfunction, leading to serious risks for both mother and baby. This stu...

Nicotinamide Adenine Dinucleotide Precursors and Their Role in Ovarian Health: Review

SynopsisNatural NAD⁺ precursors may support ovarian health, but their tissue targets, efficiency, and side effects vary. This review outlines NAD+'s distribution inside and outside cells, its compl...

Nicotinamide Riboside Protects Against Maternal Acetaminophen Exposure: Preclinical Findings

Synopsis Acetaminophen (APAP) is widely used by pregnant women to relieve pain and fever, but recent evidence suggests it may harm fetal development, especially during the sensitive period of egg ...

Nicotinamide Mononucleotide and Nicotinamide Riboside Rejuvenate Ovarian Function: Preclinical Findings

Synopsis As women age, their ovarian function and egg quality decline, partly due to mitochondrial dysfunction—an imbalance between mitochondrial fission and fusion that leads to energy stress and...

Supplementation with NAD+ and Its Precursors: Potential for Female Reproductive Health: Review

SynopsisNAD+ is an essential molecule involved in many disease processes, and supplementing it or its precursors has emerged as a potential treatment strategy. It also plays an important role in re...

Nicotinamide Riboside Restores Sperm Production and Male Fertility: Preclinical Findings

Synopsis Male infertility is a widespread issue, and one cause may be mutations in the BNC1 gene, which is crucial for sperm development. This study found that mice with a Bnc1 mutation showed spe...

The Impact of Nicotinamide Adenine Dinucleotide Deficiency on Mammalian Development: Review

SynopsisNAD+ is a molecule made from tryptophan or vitamin B3 that's essential for many cell processes. During pregnancy, NAD+ deficiency can cause congenital NAD+ deficiency disorder (CNDD), which...

Impact of NAD+ Metabolism on Ovarian Aging: Review

SynopsisNAD+ is a key coenzyme for energy production and many other vital cell functions, including metabolism, DNA repair, gene regulation, aging, and immune health. Low NAD+ levels are directly l...

Maternal Nicotinamide Riboside Protects Against Cardiac Mitochondrial Dysfunction and Supports Fetal Growth: Preclinical Findings

SynopsisGestational hypoxia reduces fetal growth and impairs heart and placental mitochondrial function, partly by limiting NAD+ and energy production. In this study, pregnant guinea pigs were expo...

Nicotinamide Riboside Maintains Spermatogonial Stem Cell Function and DNA Integrity: Preclinical Findings

Synopsis Tree shrews, small mammals closely related to primates, are valuable models for biomedical and genetic research. Scientists previously developed a spermatogonial stem cell (SSC) gene-edit...

Nicotinamide Riboside Protects Against Ovarian Aging: Preclinical Findings

Synopsis Recent research shows that NAD+, an important molecule for cell health, plays a key role in ovarian aging, but it was unclear how NAD+ made from scratch in the body affects fertility. In ...

Nicotinamide Riboside Supports Cartilage Cell Survival and Normal Bone Growth: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is critical for energy metabolism and bone development. Researchers generated mice lacking NAMPT, an essential enzyme in the NAD+ salvage pathway,...

Nicotinamide Riboside Protects Against Ovarian Injury in Sepsis: Preclinical Findings

Synopsis This study examined whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, can protect against oxidative stress and tissue injury caused by sepsis in rats. Researchers cre...