Nicotinamide Riboside Restores Metabolic Balance in Muscle Cells by Reversing NAD+ Depletion: Preclinical Findings

Synopsis Skeletal muscle plays a key role in overall body metabolism, but aging and disease can reduce its ability to function properly. Researchers studied how changes in NAD+ levels affect muscl...

Maternal Nicotinamide Riboside Supplementation Supports Postpartum Recovery and Offspring Brain Health: Preclinical Findings

Synopsis Metabolic stress can disrupt the balance of NAD+ molecules in the body. Nicotinamide riboside (NR) helps restore NAD+ levels and protect against such stress. This study tested whether NAD...

In Ovo Nicotinamide Riboside Injection Improves Broiler Chicken Muscle Growth: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR) affects the development and growth of the pectoralis major muscle (PM) in broiler chickens. Fertilized eggs were injected on day 10 of i...

Effects of High-Dose Nicotinamide Riboside on White Fat Tissue Function and Insulin Sensitivity: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin that helps produce NAD+, a key molecule for metabolism. Although reports of negative effects from high doses of NR are rare, this study examined ho...

Effects of Senolytic Drugs on Human Stem-Like Cells: Preclinical Findings

Synopsis Senolytic drugs are believed to target and remove senescent cells, potentially rejuvenating tissues and improving health and lifespan in aging models. This study tested four senolytic com...

CD38 Deletion and Nicotinamide Riboside Supplementation Slow Axon Degeneration After Facial Nerve Injury: Preclinical Findings

Synopsis After facial nerve injury (axotomy), nerve function often does not fully recover due to axon degeneration, neuron death, and ongoing inflammation. CD38, an enzyme that breaks down NAD+, m...

Extracellular NAD+ Broken Down by Human Cells to Maintain Intracellular NAD+ Levels: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and human cells replenish NAD+ by using extracellular precursors like nicotinamide (NAM), nicotinic ac...

Coronavirus Disrupts NAD+ Metabolism, While Nicotinamide Riboside Decreases Viral Replication: Preclinical Findings

Synopsis Certain enzymes called PARPs, which use NAD+ to modify proteins, play a role in the body’s defense against coronaviruses. Researchers found that SARS-CoV-2 infection increases the levels ...

Nicotinamide Riboside Demonstrates Cardioprotective Effects by Boosting Mitochondrial Stress Response: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) helps cells manage misfolded proteins in mitochondria to maintain function. Cardiac mitochondria are essential for contractile function...

Gut Bacteria Support NAD+ Production: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for hundreds of cellular processes, including metabolism, DNA repair, and aging. How environmental factors affect NAD+ metabolism is ...

The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...

Muscle Loss and Reduced Physical Performance in Emery–Dreifuss Muscular Dystrophy: Preclinical Findings

Synopsis Autosomal Emery–Dreifuss muscular dystrophy (EDMD) is caused by mutations in the lamin A/C gene (LMNA), which encodes nuclear envelope proteins. The disease typically causes muscle wastin...

CD38 Inhibitor Reverses Age-Related NAD+ Decline and Metabolic Dysfunction: Preclinical Findings

Synopsis Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD+) is a key factor for the de...

Nicotinamide Riboside Enhances Muscle Growth and Fiber Density in Chicken Embryos: Preclinical Findings

Synopsis Researchers injected nicotinamide riboside (NR) into fertilized chicken eggs to study its effects on muscle growth. NR increased the weight, length, and width of the pectoral muscles in c...

Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings

Objectives To evaluate whether combining aerobic exercise with nicotinamide riboside (NR) could enhance blood pressure (BP) control in sedentary older adults with hypertension. Journal GeroScience...

Is NAD+ a Key Factor in Ovarian Aging and Dysfunction? Current Insights and Uncertainties: Review

SynopsisRecent studies highlight NAD+ as a key player in energy metabolism, stress response, and aging, and boosting NAD+ may help treat female infertility. This review explores how NAD+ works in t...

Role of NAD+ in Aging and Disease: Review

SynopsisNAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive declin...

Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS). Journal Aging Cell Key Outcomes NR improved arterial stiffness, as measured by the...

NAD+ Augmentation as a Disease-Modifying Strategy for Neurodegeneration: Review

SynopsisNeurodegenerative diseases are a growing global health problem with no current treatments that slow or stop their progression. Boosting nicotinamide adenine dinucleotide (NAD+) has emerged ...

Nicotinamide Riboside Supplementation Reduces Oxidative Stress and Enhances Mitochondrial Function in Chronic Kidney Disease Immune Cells: Clinical Findings

Objectives To investigate the effects of NR and CoQ10 on oxidative stress, inflammation, and mitochondrial function in patients with chronic kidney disease (CKD). Journal Clinical Journal of the A...