Comparative Analysis of Nicotinamide Mononucleotide and Nicotinamide Riboside in Protecting HeLa Cells From Cisplatin-Induced DNA Damage: Preclinical Findings

Synopsis Cisplatin, a common chemotherapy drug, works by damaging DNA in cancer cells—but it can also harm healthy cells, leading to side effects. This study compared two vitamin B3–derived NAD+ p...

Nicotinamide Riboside Attenuates Inflammation and Promotes Functional Recovery After Spinal Cord Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), levels of nicotinamide adenine dinucleotide (NAD+)—a vital molecule for energy metabolism and cell repair—drop significantly, contributing to inflammatio...

Stem Cell Extracellular Vesicles Loaded with Nicotinamide Riboside, NAD+, and Resveratrol Rejuvenate Skin and Prevent Photoaging: Clinical Findings

Objectives To investigate the potential synergistic effects of loading small extracellular vesicles from adipose (fat)-derived stem cells (ASC-sEVs) with NR, NAD+, and resveratrol on photoaging an...

Nicotinamide Riboside Restores Mitochondrial Function in Alpers’ Syndrome: Preclinical Findings

SynopsisAlpers' syndrome is a devastating early-onset neurodegenerative disorder caused by POLG mutations impairing mitochondrial DNA replication. Patient-derived iPSCs were used to create brain or...

Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

SynopsisReduced NAD+ signaling contributes to nerve degeneration in diabetic peripheral neuropathy. Researchers tested NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, in cul...

Nicotinamide Riboside Reverses Pulmonary Hypertension: Preclinical Findings

Synopsis Pulmonary hypertension (PH) is a deadly lung vascular disease caused by endothelial dysfunction and vascular remodeling that strain the heart. This study identified Sirtuin 7 (SIRT7)—a NA...

Nicotinamide Riboside Reverses Metabolic Dysfunction in Werner's Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) features premature aging and metabolic dysfunction, yet mechanisms remain unclear. This study found that loss of the WRN protein accelerates early fat cell formation in...

Nicotinamide Riboside Boosts NAD+, to Reduce Sleep Need and Support Brain Energy: Preclinical Findings

SynopsisNon-rapid eye movement sleep (NREMS) is linked to lower brain glucose use, which slows metabolic reactions involving NAD+. This study tested whether boosting NAD+ with nicotinamide riboside...

Combination Therapy with Nicotinamide Riboside, Pterostilbene, and Ibudilast Protects Motor Neurons and Prolongs Survival in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by oxidative stress, inflammation, and the progressive death of motor neurons. This study tested a triple t...

NAMPT Inhibition in Neuroendocrine Cancers and the Role of NAD+ Precursors: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme that helps cancer cells make NAD+, a molecule essential for energy production and survival. Drugs that block NAMPT (NAMPT in...

Nicotinamide Riboside Restores Sperm Production and Male Fertility: Preclinical Findings

Synopsis Male infertility is a widespread issue, and one cause may be mutations in the BNC1 gene, which is crucial for sperm development. This study found that mice with a Bnc1 mutation showed spe...

The Impact of Nicotinamide Adenine Dinucleotide Deficiency on Mammalian Development: Review

SynopsisNAD+ is a molecule made from tryptophan or vitamin B3 that's essential for many cell processes. During pregnancy, NAD+ deficiency can cause congenital NAD+ deficiency disorder (CNDD), which...

Impact of NAD+ Metabolism on Ovarian Aging: Review

SynopsisNAD+ is a key coenzyme for energy production and many other vital cell functions, including metabolism, DNA repair, gene regulation, aging, and immune health. Low NAD+ levels are directly l...

Nicotinamide Riboside Attenuates NASH Progression: Preclinical Findings

Synopsis Non-alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease driven by oxidative stress and inflammation. This study investigated whether increasing NADPH, a key molecule ...

High-Dose Nicotinamide Riboside Supplementation Provides Benefits in Parkinson’s Disease: Clinical Findings

Objectives To assess the safety of high-dose NR through the absence of clinically significant adverse events, and assess short-term tolerability and impacts on NAD+, as well as clinical severity o...

Nicotinamide Riboside Improves Mitochondrial Function and Survival Post-Heart Attack: Preclinical Findings

SynopsisMyocardial infarction (MI), or heart attack, is a leading cause of death, and reduced NAD+ levels in the heart can worsen damage after MI. This study tested whether nicotinamide riboside (N...

Nicotinamide Riboside Supplementation in Mild Cognitive Impairment: Clinical Findings

Objectives To determine the safety of oral NR supplementation in older adults with mild cognitive impairment (MCI), and investigate its effects on cognition, brain volume and functioning, and phys...

Role of nadR Gene in Growth and Virulence of Streptococcus suis Bacteria: Preclinical Findings

SynopsisStreptococcus suis serotype 2 (SS2) is a harmful bacterium in pigs that can also infect humans. This study investigated the role of the nadR gene, which helps make and transport NAD+ inside...

Raising NAD+ via Nicotinamide Riboside Enhances Heart Function in Heart Failure: Preclinical Findings

SynopsisBoosting cellular NAD⁺ levels has been shown to prevent heart problems in various models of heart failure, but how it works at the molecular level is not fully understood. Most studies focu...

Maternal Nicotinamide Riboside Protects Against Cardiac Mitochondrial Dysfunction and Supports Fetal Growth: Preclinical Findings

SynopsisGestational hypoxia reduces fetal growth and impairs heart and placental mitochondrial function, partly by limiting NAD+ and energy production. In this study, pregnant guinea pigs were expo...