Article: NAD+ Precursors Restore Mitophagy and Reverse Aging Markers: Preclinical Findings

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Mitochondrial Health Preclinical

NAD+ Precursors Restore Mitophagy and Reverse Aging Markers: Preclinical Findings

Synopsis

Selective removal of damaged mitochondria (mitophagy) is crucial for cell health. Human cells show active basal mitophagy, mediated by the PINK1/Parkin pathway and p62 as a receptor. Mitophagy declines during cellular senescence and natural aging, causing mitochondrial dysfunction. Inhibiting mitophagy in healthy cells triggers aging, while reactivating it—through NAD+ precursors, rapamycin, or p62-targeting compounds—reverses aging markers. This highlights mitochondrial quality control as a promising target for anti-aging interventions.

Journal

Developmental Cell

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Diabetes

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

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Neurological Health

NAD+ Depletion Triggers SARM1 Activation and Cell Death, Prevented by PARP Inhibitors: Preclinical Findings

SynopsisSarm1 is a protein that drives programmed axon degeneration by breaking down NAD⁺, but its activity is controlled by NAD+ levels. This study found that in cells treated with the mitochondri...

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