Article: NAD+ Precursors Restore Mitophagy and Reverse Aging Markers: Preclinical Findings

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Mitochondrial Health Preclinical

NAD+ Precursors Restore Mitophagy and Reverse Aging Markers: Preclinical Findings

Synopsis

Selective removal of damaged mitochondria (mitophagy) is crucial for cell health. Human cells show active basal mitophagy, mediated by the PINK1/Parkin pathway and p62 as a receptor. Mitophagy declines during cellular senescence and natural aging, causing mitochondrial dysfunction. Inhibiting mitophagy in healthy cells triggers aging, while reactivating it—through NAD+ precursors, rapamycin, or p62-targeting compounds—reverses aging markers. This highlights mitochondrial quality control as a promising target for anti-aging interventions.

Journal

Developmental Cell

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