The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone o...

Nicotinamide Riboside Reduces Liver Fibrosis: Preclinical Findings

Synopsis Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum, which currently has no approved pharmacological treatment. Researchers tested whether nicotinamide ribosi...

Nicotinamide Riboside Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Damage to sensory nerves can cause peripheral neuropathy after chemotherapy. Increasing levels of nicotinamide adenine dinucleotide (NAD+) can protect nerves from injury. This study teste...

Nicotinamide Riboside Improves Social Behavior and Anxiety in Autism: Preclinical Findings

Synopsis Oxytocin (OT) is essential for social recognition, memory, and emotional behaviors, and it also reduces anxiety, especially during stress. CD38 is an enzyme that produces cyclic ADP-ribos...

Nicotinamide Riboside Reduces Chemotherapy-Induced Peripheral Neuropathy and Suppresses Tumor Growth: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin B3 precursor of NAD+ that blunts diabetic and chemotherapy-induced peripheral neuropathy in preclinical models. This study tested whether NR also r...

Nicotinamide Riboside Lowers Cardiometabolic Risk Factors and Cardiac Oxidative Stress: Preclinical Findings

Synopsis Nicotinamide riboside (NR), known to boost NAD levels, was tested alone and combined with calorie restriction (CR) to evaluate effects on obesity and heart health in rats fed a high-calor...

Nicotinamide Riboside Protects Neurons More Effectively Than NAD+: Preclinical Findings

Synopsis Loss of NAD+ is common in neurodegenerative diseases. Excitotoxicity, caused by excessive stimulation of neurons, leads to nerve damage. This study found that nicotinamide riboside (NR), ...

Nicotinamide Riboside Kinases Mediate NMN and NR Metabolism in Muscle Cells: Preclinical Findings

Synopsis Increasing NAD+ levels may help protect muscles from age-related decline. This study examined how skeletal muscle cells make NAD+ from precursors nicotinamide mononucleotide (NMN) and nic...

Nicotinamide Riboside Increases Heat Production in Lean Mice: Preclinical Findings

Crisol BM, Veiga CB, Lenhare L, Braga RR, Silva VRR, da Silva ASR, Cintra DE, Moura LP, Pauli JR Abstract Journal Life Sci Model Mouse Impact Factor 3.234 Aims Nicotinamide Riboside (NR) is a ...

Nicotinamide Riboside Protects Against Liver Fibrosis: Preclinical Findings

Synopsis Nicotinamide riboside (NR) boosts NAD+ levels and offers protective effects in various diseases, but its role in liver fibrosis is unclear. This study tested NR’s ability to protect again...

Nicotinamide Riboside Protects Heart Function in Dilated Cardiomyopathy: Preclinical Findings

Synopsis In chronic heart failure, the heart’s energy metabolism is severely impaired. NAD+ is a key molecule that helps cells produce energy and respond to stress, making it an important focus in...

Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

Synopsis Alcohol causes liver damage by lowering the activity of SIRT1, a protein that regulates fat metabolism and mitochondrial function. Giving mice nicotinamide riboside (NR), an NAD+ precurso...

NAD+ Biosynthesis Enzyme Protects Aortic Smooth Muscle Cells: Preclinical Findings

Synopsis The walls of the aorta weaken with age and stress, risking serious damage. Smooth muscle cells (SMCs) in the aorta need NAD+, made by the enzyme NAMPT, for health. In humans with aortic d...

Nicotinamide Riboside Improves Alzheimer's Features and DNA Repair: Preclinical Findings

Synopsis Alzheimer’s disease (AD) involves problems with energy metabolism and DNA repair, but how these contribute to key AD features is unclear. A DNA repair-deficient AD mouse model (3xTgAD/Pol...

Nicotinamide Riboside Rejuvenates Aging Gut Stem Cells: Preclinical Findings

Synopsis Aging leads to tissue decline partly due to reduced function of adult stem cells. In the intestine, the number and activity of intestinal stem cells (ISCs) decrease with age, while Paneth...

Nicotinamide Riboside Reduces Brain Inflammation and Cellular Aging in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease, brain cells often show low NAD+ levels, high inflammation, and impaired cellular cleanup of damaged components. In mice with Alzheimer’s-like brain changes, five m...

Nicotinamide Ribosides Improves Aerobic Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that helps increase NAD+ and improve mitochondrial function, but its effect on physical fitness is unclear. In a study with sedentary an...

NAD+ Replenishment Prevents Thymus Atrophy and Liver Fat Accumulation: Preclinical Findings

Synopsis Dioxin (TCDD) is a highly toxic chemical that causes serious health problems like wasting, liver fat buildup, and thymus shrinkage in animals. Its toxic effects happen when it activates a...

Nicotinamide Riboside Reverses Age-Related Circadian and Mitochondrial Decline: Preclinical Findings

Synopsis Aging disrupts sleep patterns and circadian rhythms, which are linked to metabolic diseases and lower NAD+ levels. This study shows that supplementing with the NAD+ precursor nicotinamide...